A5063574338- Fibroblast Growth Factor Research
- Multiple Myeloma Research and Treatments
- Biomarkers in Disease Mechanisms
- Mast cells and histamine
- Cancer Mechanisms and Therapy
- Circular RNAs in diseases
- Quinazolinone synthesis and applications
- Liver physiology and pathology
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Hematopoietic Stem Cell Transplantation
- Epigenetics and DNA Methylation
- Microtubule and mitosis dynamics
- Kruppel-like factors research
- Cancer, Hypoxia, and Metabolism
- Protein Degradation and Inhibitors
- Proteoglycans and glycosaminoglycans research
- Venous Thromboembolism Diagnosis and Management
- Histone Deacetylase Inhibitors Research
- Hippo pathway signaling and YAP/TAZ
- RNA Interference and Gene Delivery
- Lysosomal Storage Disorders Research
- Cancer Cells and Metastasis
- Lymphatic System and Diseases
- Prostate Cancer Treatment and Research
Brescia University
2019-2024
University of Brescia
2019-2024
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
2024
Abstract Multiple myeloma, the second most common hematologic malignancy, frequently relapses because of chemotherapeutic resistance. Fibroblast growth factors (FGF) act as proangiogenic and mitogenic cytokines in multiple myeloma. Here, we demonstrate that autocrine FGF/FGFR axis is essential for myeloma cell survival progression by protecting cells from oxidative stress–induced apoptosis. In keeping with hypothesis intracellular redox status can be a target cancer therapy, blockade FGF...
Lung cancer represents an extremely diffused neoplastic disorder with different histological/molecular features. Among the lung tumors, non-small-cell (NSCLC) is most represented histotype, characterized by various molecular markers, including expression/overexpression of fibroblast growth factor receptor-1 (FGFR1). Thus, FGF/FGFR blockade tyrosine kinase inhibitors (TKi) or FGF-ligand may represent a promising therapeutic approach in cancers. In this study we demonstrate potential benefit...
Bladder tumors are a diffuse type of cancer. Long pentraxin-3 (PTX3) is component the innate immunity with pleiotropic functions in regulation immune response, tissue remodeling, and cancer progression. PTX3 may act as an oncosuppressor different contexts, functioning antagonist fibroblast growth factor/fibroblast factor receptor (FGF/FGFR) system, rewiring microenvironment, or acting through mechanisms not yet fully clarified. In this study we used biopsies data mining to assess that...
Fibroblast growth factors (FGFs) act as proangiogenic and mitogenic cytokines in several cancers, including multiple myeloma (MM). Indeed, corrupted FGF autocrine paracrine secretion induces an aberrant activation of the receptor (FGFR) signaling sustaining cancer cell spreading resistance to pharmacological treatments. Thus, traps may represent a promising anti-cancer strategy hamper ligand-dependent FGF/FGFR system. We previously identified NSC12 first orally available small molecule trap...
During multiple myeloma (MM) progression the activation of angiogenic process represents a key step for formation vascular niche, where different stromal components and neoplastic cells collaborate foster tumor growth. Among pro-angiogenic players, Fibroblast Growth Factor 2 (FGF2) plays pivotal role in BM vascularization occurring during MM progression. Long Pentraxin 3 (PTX3), natural FGF antagonist, is able to reduce promoted by FGF2 various vitro models. An increased FGF/PTX3 ratio has...
Krabbe disease (KD) is an autosomal recessive sphingolipidosis caused by the deficiency of lysosomal hydrolase β-galactosylceramidase (GALC). Oligodendroglia degeneration and demyelination nervous system lead to neurological dysfunctions which are usually lethal two years age. At present, only clinical treatment with any proven efficacy hematopoietic stem-cell transplantation, more effective when administered in neonatal period presymptomatic recipients. Bone marrow (BM) sinusoidal...
<p>Single file with supplemental figures, methods, tables, legends: Figure S1: Effects of FGF blockade in MM; S2: inhibition induces oxidative stress-mediated apoptosis MM cells; S3: Mitochondrial stress is responsible for the antitumor activity exerted vivo by inhibition; S4: Oxidative stress-induced following c-Myc-dependent; S5: Western blot analysis caspase 3 activation PBMCs compared to NSC12-sensitive patient-derived cells treated NSC12 12 hours; S6: BTZ-resistant KMS-11 S7: High...
<p>Single file with supplemental figures, methods, tables, legends: Figure S1: Effects of FGF blockade in MM; S2: inhibition induces oxidative stress-mediated apoptosis MM cells; S3: Mitochondrial stress is responsible for the antitumor activity exerted vivo by inhibition; S4: Oxidative stress-induced following c-Myc-dependent; S5: Western blot analysis caspase 3 activation PBMCs compared to NSC12-sensitive patient-derived cells treated NSC12 12 hours; S6: BTZ-resistant KMS-11 S7: High...
<div>Abstract<p>Multiple myeloma, the second most common hematologic malignancy, frequently relapses because of chemotherapeutic resistance. Fibroblast growth factors (FGF) act as proangiogenic and mitogenic cytokines in multiple myeloma. Here, we demonstrate that autocrine FGF/FGFR axis is essential for myeloma cell survival progression by protecting cells from oxidative stress–induced apoptosis. In keeping with hypothesis intracellular redox status can be a target cancer...
<div>Abstract<p>Multiple myeloma, the second most common hematologic malignancy, frequently relapses because of chemotherapeutic resistance. Fibroblast growth factors (FGF) act as proangiogenic and mitogenic cytokines in multiple myeloma. Here, we demonstrate that autocrine FGF/FGFR axis is essential for myeloma cell survival progression by protecting cells from oxidative stress–induced apoptosis. In keeping with hypothesis intracellular redox status can be a target cancer...
Abstract Bladder tumors are a diffuse type of cancer with relatively benign prognosis when treated at early stage/low-grade stages, but poor outcome in the muscle invasive (MIBC) form or recurrence. Long Pentraxin-3 (PTX3) is component innate immunity pleiotropic functions regulation immune response, tissue remodeling and progression. PTX3 may act as an oncosuppressor different contexts, functioning antagonist FGF/FGFR system, rewiring immune-microenvironment acting through mechanisms not...
Abstract Multiple myeloma (MM) remains incurable because of chemotherapeutic resistance. Fibroblast growth factors (FGF) play a pivotal role in MM by acting as an autocrine/paracrine mitogen on plasma cells, bone marrow-derived endothelial cells and fibroblasts. Also, recurrent chromosomal translocation t(4;14) is associated with FGFR3 upregulation patients. Thus, agents able to hamper FGF signaling may represent novel approach for treatment. Recently we have identified the PTX3-derived...