A5081097888- Ocular Infections and Treatments
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Cellular Mechanics and Interactions
- Spectroscopy Techniques in Biomedical and Chemical Research
- Phytochemicals and Antioxidant Activities
- Lysosomal Storage Disorders Research
- Plant chemical constituents analysis
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Inflammatory mediators and NSAID effects
- Natural Antidiabetic Agents Studies
- Circular RNAs in diseases
- Essential Oils and Antimicrobial Activity
- Retinal Development and Disorders
- Nanoplatforms for cancer theranostics
- Phytochemistry and Biological Activities
- Antimicrobial Resistance in Staphylococcus
- Force Microscopy Techniques and Applications
- Plant tissue culture and regeneration
- Ocular Surface and Contact Lens
- Glycosylation and Glycoproteins Research
- Extracellular vesicles in disease
- Spectroscopy and Chemometric Analyses
- Optical Coherence Tomography Applications
Shiraz University of Medical Sciences
2021-2025
TU Dresden
2020-2024
Tabriz University of Medical Sciences
2021
Control Vision (United States)
2013
Clinical Research Management
2011
University of California, San Francisco
2009
The University of Texas Medical Branch at Galveston
2002-2004
Maastricht University
2003
Excessive lipid accumulation in Bruch's membrane (BrM) is a hallmark of ageing, the major risk factor for age-related macular degeneration (AMD). Retinal pigment epithelial (RPE) cells may utilise reverse cholesterol transport (RCT) activity to move into BrM, mediated through ATP-binding cassette A1 (ABCA1) and scavenger receptor BI (SR-BI).ABCA1 expression was assessed by transcription polymerase chain reaction (RT-PCR) western blotting human RPE cell extracts. Lipid assays were performed...
Abstract Niemann–Pick disease (NPD) is another type of metabolic disorder that classified as lysosomal storage diseases (LSDs). The main cause the mutation in SMPD1 (type A and B) or NPC1 NPC2 C) genes, which lead to accumulation lipid substrates lysosomes liver, brain, spleen, lung, bone marrow cells. This followed by multiple cell damage, dysfunction lysosomes, finally body organs. So far, about 346, 575, 30 mutations have been reported , respectively. Depending on clinical symptoms...
Dexamethasone is a corticosteroid with proven efficacy for treating both anterior- and posterior-segment ocular diseases. Delivery of drugs to the back eye has always been challenge, dexamethasone being no exception. There are multiple delivery routes retina, each exhibiting different pharmacokinetics, depending on drug molecule specific route administration. In this study, we used intravenous (IV), subconjunctival (SC), intravitreal (IVT) injections in rabbits determine pharmacokinetics...
Growing data suggest that the antibiotic azithromycin mediates anti-inflammatory activity through inhibition of transcription factor NF-kappaB. The purpose this study was to compare azithromycin's potency with hydrocortisone and dexamethasone as measured in an activated NF-kappaB assay. Dose-response curves corresponding inhibitory potencies (IC(50)) azithromycin, hydrocortisone, were evaluated a fluorescence assay using A549 cells. All three compounds inhibited TNFalpha stimulated...
Falcaria vulgaris Bernh among the most important member of Apiaceae family has been used for medical investigation in Iran and some regions world. This plant possesses a range coumarin flavonoids compounds that have many therapeutic properties such as gastrointestinal liver diseases, skin ulcers, gastric intestinal inflammation. It also found these lead to cytotoxic effects.This study contains concentrates on effect induction apoptosis cancerous cells (SW-872) through various extracts...
A prior study showed that brain-derived neurotrophic factor (BDNF) rescues photoreceptors from collateral retinal damage caused by photodynamic therapy (PDT). This was conducted to determine whether ciliary (CNTF), a combination of BDNF and CNTF, or pigment epithelial cell-derived growth (PEDF) might protect function more effectively than BDNF. Also investigated protection would be observed after second round PDT with adjunctive treatment.Normal rats received intravitreal injections BDNF,...
This paper proposes a sustainable simulation method for managing energy resources from the point of view virtual power players (VPP) operating in smart grid. The proposed resource management schedule micro-grid, including fuel cells, micro turbines, solar panels, wind and batteries, intelligently meets needs Apart using aforementioned resources, VPP can also purchase additional upper utility to respond load. In addition, plans suitably micro-grid multi-objective framework, which minimizes...
To investigate possible ototoxic effects of topical azithromycin (AZ) in the guinea pig.A prospective, controlled animal study.The University Texas Southwestern Medical Center at Dallas.Twenty-three pigmented pigs were given single, unilateral middle ear applications a solution containing 3% (n = 3), 2% 5), 1% or 0.5% 5) AZ saline 5). The contralateral served as untreated control.The animals observed for behavioral changes 2 weeks and then humanely killed. ears processed anatomical...
Abstract Purpose To develop a non‐contact and non‐invasive method for quantification of the local concentration certain antibiotic antifungal drugs in eye. Study Design/Materials Methods An integrated CCD‐based Raman spectroscopic system designed specifically ophthalmic applications was used to non‐invasively detect presence ceftazidime amphotericin B ocular media. Specific signatures above named were determined various concentrations that injected through needle aqueous humor rabbit eyes...
Eryngium is a genus flowering plant in the Umbelliferae family, having pharmacological properties, such as anti-inflammatory and anti-diabetic. Given nature of melanoma breast cancers recent years fact that anti-cancer properties billardieri on mentioned cell lines have not been studied, present study was conducted to explore these properties. The mechanisms cytotoxicity apoptosis aerial parts various extracts fractions E. cancerous cells normal were investigated. Samples collected from...