Clinacanthus nutans Lindau is a well-known plant, native to tropical Asian countries. Reports on this plant that rich in phenolic compounds have focused its therapeutic anti-inflammatory, anti-herpes simplex, antioxidant, and anti-cancer characteristics. In paper, the influence of extraction parameters-temperatures (60-80 °C), times (80-120 min), solvent ratios (70:30-90:10) water:ethanol were investigated using response surface methodology order determine optimum conditions could produce...

Fe3O4/talc nanocomposite was used for removal of Cu(II), Ni(II), and Pb(II) ions from aqueous solutions. Experiments were designed by response surface methodology (RSM) a quadratic model to predict the variables. The adsorption parameters such as adsorbent dosage, time, initial ion concentration independent variables their effects on heavy metal investigated. Analysis variance incorporated judge adequacy models. Optimal conditions with 100, 92 270 mg/L, 120 s time 0.12 g amount resulted in...

Response surface methodology (RSM) was used to optimize the formulation of a nanoemulsion for central delivery following parenteral administration. A mixture medium-chain triglyceride (MCT) and safflower seed oil (SSO) determined as sole phase from emulsification properties. Similarly, natural surfactant (lecithin) non-ionic (Tween 80) (ratio 1:2) were in formulation. composite design (CCD) with three-factor at five-levels processing method high energy ultrasonicator. Effects pre-sonication...

Rice straw/magnetic nanocomposites (RS/Fe3O4-NCs) were prepared via co-precipitation method for removal of Pb(II) and Cu(II) from aqueous solutions. Response surface methodology (RSM) was utilized to find the optimum conditions ions. The effects three independent variables including initial ion concentration, time, adsorbent dosage investigated on maximum adsorption Pb (II) Cu (II). obtained (100 60 mg/L) (41.96 59.35 s) time 0.13 g both ions, respectively. efficiencies 96.25% 75.54%, In...

The D-optimal mixture experimental design was employed to optimize the melting point of natural lipstick based on pitaya (Hylocereus polyrhizus) seed oil. influence main components—pitaya oil (10%–25% w/w), virgin coconut (25%–45% beeswax (5%–25% candelilla wax (1%–5% w/w) and carnauba w/w)—were investigated with respect properties formulation. applied by focusing above influencing components. analysis showed that variation in response (melting point) could be depicted as a quadratic...

Abstract: Psoriasis is a chronic autoimmune disease that cannot be cured. It can however controlled by various forms of treatment, including topical, systemic agents, and phototherapy. Topical treatment the first-line favored most physicians, as this form therapy has more patient compliance. Introducing nanoemulsion for transporting cyclosporine an anti-inflammatory drug to itchy site skin would enhance effectiveness topical psoriasis. The addition nutmeg virgin coconut-oil mixture, with...

Enhancement of encapsulation efficiency nanoemulsion-containing aripiprazole for the treatment schizophrenia using mixture experimental design Hamid Reza Fard Masoumi, Mahiran Basri, Wan Sarah Samiun, Zahra Izadiyan, Chaw Jiang Lim Nanodelivery Group, Department Chemistry, Faculty Science, Universiti Putra Malaysia, Serdang, Selangor, Malaysia Abstract: Aripiprazole is considered as a third-generation antipsychotic drug with excellent therapeutic efficacy in controlling symptoms and was...

The usage of soy is increasing year by year. It increases the problem financial crisis due to limited sources soybeans. Therefore, production oral tablets containing nutritious leftover soymilk production, called okara, as main ingredient was investigated. okara were produced using direct compression method. percentage guar gum, microcrystalline cellulose (Avicel PH-101), and maltodextrin influenced tablets' hardness friability which are analyzed a D-optimal mixture design. Composition...

A Taguchi robust design method with an L9 orthogonal array was implemented to optimize experimental conditions for the biosynthesis of triethanolamine (TEA)-based esterquat cationic surfactants using enzymatic reaction method. The esterification conversion% considered as response. Enzyme amount, time, temperature and molar ratio substrates, [oleic acid: (OA:TEA)] were chosen main parameters. As a result analysis in this study, substrates found be most influential parameter on conversion%....

In this work, lipase from Candida rugosa was immobilized onto chitosan/graphene oxide beads. This to provide an enzyme-immobilizing carrier with excellent enzyme immobilization activity for group requiring hydrophilicity on the immobilizing carrier. addition, work involved a process preparation of enzymatically active product insoluble in reaction medium consisting lauric acid and oleyl alcohol as reactants hexane solvent. enabled stability under working conditions allowed be readily...

Schematic diagram of the upstream and downstream factors affecting transgene expression.

The particle size of Virgin coconut oil nanoemulsions was optimized using D-optimal mixture design and the optimum formulation physicochemically characterized.

Since Reactive Blue 21 (RB21) is one of the dye compounds which harmful to human life, a simple and sensitive method remove this pollutant from wastewater using Nano Zero-Valent Iron (NZVI) catalyst. In paper, Central Composite Rotatable Design (CCRD) was employed for response surface modeling optimize experimental conditions RB21 removal aqueous solution. The significance adequacy model were analyzed analysis variance (ANOVA). Four independent variables—including catalyst amount (0.1–0.9...

<italic>C. nutans</italic>is a well-known medicinal plant in South-East Asia that has attracted attention for its therapeutic characteristics. In this work, nanoemulsion been chosen to be carrier encapsulation of<italic>C. nutans</italic>extract potential nanotechnology application.

Kojic acid is widely used to inhibit the browning effect of tyrosinase in cosmetic and food industries. In this work, synthesis kojic monooleate ester (KMO) was carried out using lipase-catalysed esterification oleic a solvent-free system. Response Surface Methodology (RSM) based on central composite rotatable design (CCRD) optimise main important reaction variables, such as enzyme amount, temperature, substrate molar ratio, time along with immobilised lipase from Candida Antarctica (Novozym...

The aim of this study is the development nanoemulsions for intravenous administration Sorafenib, which a poorly soluble drug with no parenteral treatment. formulation was prepared by high energy emulsification method and optimized response surface methodology. effects overhead stirring time, shear rate, cycles high-pressure homogenizer were studied in preparation nanoemulsion loaded Sorafenib. Most particles are spherical shape, smallest particle size being 82.14 nm. results...

A predictive model of a virgin coconut oil (VCO) nanoemulsion system for the topical delivery copper peptide (an anti-aging compound) was developed using an artificial neural network (ANN) to investigate factors that influence particle size. Four independent variables including amount VCO, Tween 80: Pluronic F68 (T80:PF68), xanthan gum and water were inputs whereas size taken as response trained network. Genetic algorithms (GA) used data which divided into training sets, testing sets...