A5055018262- Retinal Development and Disorders
- Glaucoma and retinal disorders
- Visual perception and processing mechanisms
- Retinal Diseases and Treatments
- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- Ocular and Laser Science Research
- Mosquito-borne diseases and control
- Retinal Imaging and Analysis
- HIV/AIDS Research and Interventions
- COVID-19 Impact on Reproduction
- Retinopathy of Prematurity Studies
- Ophthalmology and Visual Impairment Studies
- Nicotinic Acetylcholine Receptors Study
- Neural dynamics and brain function
- Birth, Development, and Health
- Phytochemistry and Biological Activities
- Spectroscopy and Chemometric Analyses
- Olfactory and Sensory Function Studies
- Color Science and Applications
- Neurological Disorders and Treatments
- Optical Coherence Tomography Applications
- Ocular Diseases and Behçet’s Syndrome
- Retinal and Macular Surgery
- Receptor Mechanisms and Signaling
University of Wisconsin–Madison
2011-2024
Madison Group (United States)
2023
Visual Sciences (United States)
2017-2020
University of California, Santa Cruz
1986-1992
<h3>Objective</h3>To characterize functional and anatomic sequelae of a bleb induced by subretinal injection.<h3>Methods</h3>Subretinal injections (100 μL) balanced salt solution were placed in the superotemporal macula 1 eye 3 cynomolgus macaques. Fellow eyes received intravitreal solution. Fundus photography, ocular coherence tomography, multifocal electroretinography performed before immediately after injection again at intervals up to months postinjection. Histopathologic analyses...
In the 2016 Zika virus (ZIKV) pandemic, a previously unrecognized risk of birth defects surfaced in babies whose mothers were infected with Asian-lineage ZIKV during pregnancy. Less is known about impacts gestational African-lineage infections. Given high human immunodeficiency (HIV) burdens regions where circulates, we evaluated whether pregnant rhesus macaques simian (SIV) have higher ZIKV-associated defects. Remarkably, both SIV+ and SIV- animals, infection early first trimester caused...
Foveal flicker contrast sensitivity was measured for healthy adults at temporal frequencies from 2.5 to 50 Hz. The first experiment compared two-interval forced-choice (2IFC) and yes-no detection (Y–N) testing procedures younger (19–33-year-old) older (67–73-year-old) observers. 2IFC technique resulted in higher absolute estimates of sensitivity. However, within a method, relative differences were similar. Therefore the two methods gave similar contrast-sensitivity change with age....
Photopic temporal contrast sensitivity for healthy eyes of observers 65 years old and older is compared with retinal-illuminance-matched younger eyes. The are significantly less sensitive frequencies between 10 45 Hz. Although there a slight shift to slower flicker rates in the mean function observers, this trend not statistically significant, suggesting that relatively little loss resolving power visual system aging. These preliminary results from an ongoing study aging
Abstract Studies of the numbers retinal ganglion cells and lateral geniculate nucleus (LGN) neurons in primates suggest that both types may vary over a two-fold range from one individual to another. This raises question whether LGN are related or independently individual. We used stereological procedures obtain unbiased estimates cell seven rhesus monkeys. found no significant correlation ( r s . = −0.21) between same animals. In agreement with previous studies, average ratio number project...
Intensive testing of spatial-frequency discrimination thresholds for 21% contrast gratings between 2.9 and 7.8 cycles/degree (c/deg) reveals, on average, smooth functions conforming to Weber's law. Discrimination overall is very sensitive, indicating highly skilled performance, but there are no consistent peaks or troughs. Individual, single-run do vary, resulting in candidate troughs that might be proposed reflect true variations an observer's sensory capacities. However, these features not...
This study used the swept spatial-frequency method to compare retinal and cortical acuity in anesthetized young adult rhesus monkeys. Visual evoked potentials (VEPs) pattern electroretinographic responses (PERGs) were recorded from 25 monkeys (age range: 4–12 years) with a continuous infusion of propofol. The stimuli temporally countermodulated sine-wave gratings that increased spatial frequency within 10.24-s period. All animals refracted using estimated zero micro-volt intercept linear...
Purpose.: The scanning laser polarimetry with variable corneal compensation (GDx VCC) methodology was established and verified in monkeys experimental glaucoma (ExpG). Terminal GDx parameters were correlated axon counts electrophysiologic measures. effects of memantine on these investigated. Methods.: ExpG induced intraocular pressure monitored weekly. Some received their diet before after induction (1–10 months). VCC scans, stereophotographs, multifocal visual evoked potential (mfVEP) data...
Microcystoid macular degeneration (MMD) is a condition where cystoid vacuoles develop within the inner nuclear layer of retina in humans variety disorders. Here we report occurrence MMD non-human primates (NHPs) with various retinal ganglion cell (RGC) pathologies and evaluate hypothesis that does not precede RGC loss but follows it.
Outer retinal injury has been well described in glaucoma. To better understand the source of this injury, we wanted to develop a reliable model partial ganglion cell (RGC) axotomy.Endodiathermy spots were placed along inferior 180° adjacent optic nerve margin right eyes four cynomolgus monkeys. Fluorescein angiography, spectral domain optical coherence tomography (SD-OCT), and multifocal electroretinography (mfERG) performed at various intervals. Two animals sacrificed 3 months. 4 months,...
To evaluate monkey multifocal visual evoked cortical potentials (mfVEPs) recorded from central and peripheral fields for reliability isolation electroretinographic (ERG) activity.The mfVEP stimulus consisted of a 7-element hexagonal array that subtended 80 degrees the field. Recordings were made under intravenous pentobarbital sodium (15 mg/kg) anesthesia. Two monkeys with absent optic nerve ganglion cell function after combined unilateral transection experimental ocular hypertension...
Abstract In the 2016 Zika virus (ZIKV) pandemic, a previously unrecognized risk of birth defects surfaced in babies whose mothers were infected with Asian-lineage ZIKV during pregnancy. Less is known about impacts gestational African-lineage infections. Given high human immunodeficiency (HIV) burdens regions where circulates, we evaluated whether pregnant rhesus macaques simian (SIV) have higher ZIKV-associated defects. Remarkably, both SIV+ and SIV-animals, infection early first trimester...
The optical imaging agent TcapQ488 has enabled of retinal ganglion cell (RGC) injury in vivo rodents and potential as an effective diagnostic probe for early detection intervention monitoring glaucoma patients. In the present study, we investigated non-human primates (NHPs) to identify labeling efficacy signals injured RGC, determine species-dependent changes RGC uptake clearance, dose-limiting toxicities. Doses 3, 6, 12 nmol were delivered intravitreally normal healthy NHP eyes that had...