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A5012681379
Research Areas
- Mitochondrial Function and Pathology
- Cancer, Hypoxia, and Metabolism
- Amino Acid Enzymes and Metabolism
Cornell University
2022
The mitochondrial enzyme glutaminase C (GAC) is upregulated in many cancer cells to catalyze the first step glutamine metabolism, hydrolysis of glutamate. dependence on this transformed metabolic pathway highlights GAC as a potentially important therapeutic target. acquires maximal catalytic activity upon binding anionic activators such inorganic phosphate. To delineate mechanism activation, we used tryptophan substitution tyrosine 466 site fluorescent reporter for presence and absence We...
10.1016/j.jbc.2022.101564
article
EN
cc-by-nc-nd
Journal of Biological Chemistry
2022-01-06
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