A5078505655- Global Maternal and Child Health
- Maternal and Perinatal Health Interventions
- Maternal and fetal healthcare
- Reproductive Health and Contraception
- HIV/AIDS Research and Interventions
- Cervical Cancer and HPV Research
- Malaria Research and Control
- Liver Disease and Transplantation
- Thermal Regulation in Medicine
- Global Cancer Incidence and Screening
- Reproductive tract infections research
- Tuberculosis Research and Epidemiology
- Syphilis Diagnosis and Treatment
- Global Health Care Issues
- Adolescent Sexual and Reproductive Health
- Preterm Birth and Chorioamnionitis
- Trauma and Emergency Care Studies
- Congenital Heart Disease Studies
- Urinary Tract Infections Management
- Cancer-related gene regulation
- Urological Disorders and Treatments
- Global Health and Epidemiology
- Immune responses and vaccinations
- Maternal and Neonatal Healthcare
- Birth, Development, and Health
Papua New Guinea Institute of Medical Research
2020-2025
UNSW Sydney
2021
BackgroundChlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, and bacterial vaginosis have been associated with adverse maternal perinatal outcomes, but there is conflicting evidence on the benefits of antenatal screening treatment for these conditions. We aimed to determine effect point-of-care testing immediate C N T preterm birth, low birthweight, other outcomes compared current standard care, which included symptom-based without laboratory confirmation.MethodsIn this...
WHO has launched updated cervical screening guidelines, including provisions for primary HPV screen-and-treat. Papua New Guinea (PNG) a high burden of cancer, but no national programme. We recently completed the first field trials screen-and-treat algorithm using point-of-care self-collected and same-day treatment (hereafter S&T) showed this had superior clinical performance acceptability to visual inspection cervix with acetic acid (VIA). We, therefore, evaluated effectiveness,...
Objective WHO recommends human papillomavirus (HPV) testing for cervical screening, with triage of high-risk HPV (hrHPV) positive women. However, there are limitations to effective low-resource, high-burden settings, such as Papua New Guinea. In this exploratory study, we assessed the performance host methylation tools predicting high-grade squamous intraepithelial lesions (HSIL) in self-collected and clinician-collected samples. Design Exploratory observational study. Setting Provincial...
In moderate-to-high malaria transmission regions, the World Health Organization recommends intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) alongside insecticide-treated bed nets to reduce adverse consequences of pregnancy-associated malaria. Due high-grade Plasmodium falciparum resistance SP, novel regimens need be evaluated for IPTp, but these increase pill burden and days. The present qualitative study assessed acceptability IPTp-SP plus...
Background: Health workers in many low- and middle-income countries are not adequately trained to provide quality antenatal intrapartum care. The freely available Safe Delivery App (the App) provides health care professionals with direct instant access evidence-based, up-to-date clinical guidelines equipping them an on-the-job reference guide, even the most remote areas. In this paper we describe uptake acceptability process develop Papua New Guinea (PNG). Methods: Between June 2022 December...
Background:Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis and bacterial vaginosis have been associated with preterm birth low weight, are highly prevalent among pregnant women in many low- middle-income settings. There is conflicting evidence on the potential benefits of screening treating these infections pregnancy. Newly available diagnostic technologies make it possible, for first time, to conduct definitive field trials fill this knowledge gap. The primary aim study...
Oral misoprostol as an induction of labour (IOL) agent is rapidly gaining popularity in resource-limited settings because it cheap, stable at ambient temperatures, and logistically easier to administer compared dinoprostone oxytocin. We aim investigate the safety effectiveness a regimen oral Papua New Guinean women undergoing IOL. As part prospective dose escalation study conducted Modilon Hospital Guinea, with singleton pregnancy cephalic presentation unfavourable cervix who gave written...
Ectopic pregnancy (EP) is an important cause of morbidity and mortality amongst women reproductive age. Tubal EP well described in industrialised countries, but less known about its impact low-resource particular the South Pacific Region.
Abstract Background Doppler velocimetry studies of umbilical artery (UA) and middle cerebral (MCA) flow help to determine the presence severity fetal growth restriction. Increased UA resistance reduced MCA pulsatility may indicate increased placental intrafetal blood redistribution. Malaria causes low birth weight restriction, but few have assessed its effects on uteroplacental fetoplacental flow. Methods Colour-pulsed ultrasound was used assess in 396 Papua New Guinean singleton fetuses....
Background Maternal near‐miss indices are World Health Organisation ( WHO ) recognised indicators that may improve our understanding of factors associated with maternal morbidity and mortality. In Papua New Guinea PNG where mortality is among the highest in world, only one study has documented a tertiary‐level hospital, but none from provincial hospitals majority under‐privileged women access healthcare services. Aims To determine ratio, index MMI ), for Modilon Hospital Madang Province ....
<ns4:p><ns4:bold>Background:</ns4:bold><ns4:italic>Chlamydia trachomatis</ns4:italic>,<ns4:italic>Neisseria gonorrhoeae</ns4:italic>,<ns4:italic>Trichomonas vaginalis</ns4:italic>and bacterial vaginosis have been associated with preterm birth and low weight, are highly prevalent among pregnant women in many low- middle-income settings. There is conflicting evidence on the potential benefits of screening treating these infections pregnancy. Newly available diagnostic technologies make it...
Background: Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis and bacterial vaginosis (BV) have been associated with adverse maternal perinatal outcomes but there is conflicting evidence on the benefits of antenatal screening treatment for these conditions.Methods: In a pragmatic cluster-randomised crossover trial in 10 primary health facilities their catchment communities Papua New Guinea, we compared point-of-care testing C. N. T. BV standard care, which included...
Abstract Background Pregnancy termination or induced abortion is not decriminalized, and access to safe services largely unavailable in Papua New Guinea (PNG). However, the practice common throughout country. This study aimed estimate prevalence determine factors associated with pregnancy among married women aged 15–49 PNG. Methods Secondary data from 2016–2018 PNG Demographic Health Survey (PNGDHS) was used. A total weighted samples of 6,288 were included. Complex Sample Analysis method...
Poor access to contraception contributes persistently high maternal mortality rates in Papua New Guinea (PNG). Since 2012 contraceptive implants have been provided women rural areas of PNG through outreach services but follow-up data these communities on continuation and acceptability is lacking.To gain insight into women's experience with by assessing the acceptability, satisfaction, 12 month efficacy among PNG.We undertook a cross-sectional survey two provinces who had received implant at...
Abstract Background Despite targeted interventions to improve contraceptive implant acceptability and uptake in rural Papua New Guinea (PNG), ongoing use of this method remains limited. Previous literature has suggested community attitudes intrinsic factors within the decision-making process may be negatively impacting on uptake, however these elements have not previously been studied detail context. We set out explore towards pathways decision making around a Karkar Island, PNG. Methods...
Abstract Background In Papua New Guinea, TB is considered to be a major public health problem, but little known about the prevalence and prognosis of presumed in children. Methods As part prospective hospital-based surveillance on northern coast mainland authors investigated admission case fatality rate associated with over 6-year period (2011–2016). All children admitted who were diagnosed followed-up until discharge or death. Results Of 8992 paediatric admissions, 734 patients (8.2%) there...
Emergency peripartum hysterectomy (EPH) is a life-saving surgical procedure performed at the time of caesarean section or within 24 h vaginal delivery and usually last resort in obstetric haemorrhage when other interventions fail.To investigate incidence, indications, risk factors complications EPH provincial referral hospital Papua New Guinea (PNG).This was seven-year retrospective observational study investigating rate between January 2012 December 2018. Patient medical records that...
Left untreated, sexually transmitted and genital infections (henceforth STIs) in pregnancy can lead to serious adverse outcomes for mother child. Papua New Guinea (PNG) has among the highest prevalence of curable STIs including syphilis, chlamydia, gonorrhoea, trichomoniasis bacterial vaginosis, high neonatal mortality rates. Diagnosis treatment these PNG rely on syndromic management. Advances STI diagnostics through point-of-care (PoC) testing using GeneXpert technology hold promise...