A5058253045- Dialysis and Renal Disease Management
- Nutrition and Health in Aging
- Erythropoietin and Anemia Treatment
- Iron Metabolism and Disorders
- Stroke Rehabilitation and Recovery
- Frailty in Older Adults
- Toxin Mechanisms and Immunotoxins
- Asthma and respiratory diseases
- Cerebral Palsy and Movement Disorders
- Fetal and Pediatric Neurological Disorders
- Neurological and metabolic disorders
- Urticaria and Related Conditions
- Infectious Encephalopathies and Encephalitis
- Therapeutic Uses of Natural Elements
- Healthcare and Venom Research
- Hemoglobinopathies and Related Disorders
- Intestinal and Peritoneal Adhesions
- Body Composition Measurement Techniques
- Microtubule and mitosis dynamics
- Central Venous Catheters and Hemodialysis
- Dermatology and Skin Diseases
- Parathyroid Disorders and Treatments
- Cellular transport and secretion
- Kidney Stones and Urolithiasis Treatments
Toranomon Hospital
2020
Toho University
2020
Takayanagi Dental Clinic
2018
The University of Tokyo
2011
Recent studies have highlighted the renoprotective effect of sirtuin1 (SIRT1), a deacetylase that contributes to cellular regulation. However, pathophysiologic role SIRT1 in podocytes remains unclear. Here, we investigated function podocytes. We first established podocyte-specific Sirt1 knockout (SIRT1(pod-/-)) mice. then induced glomerular disease by nephrotoxic serum injection. The increase urinary albumin excretion and BUN severity injury were all significantly greater SIRT1(pod-/-) mice...
Gait speed (GS) and handgrip strength (HGS), both factors associated with frailty sarcopenia, are reportedly CV events in the general population. However, little is known about impact of these on outcome patients dialysis. This study aimed to evaluate whether evaluation GS HGS could be onset fatal/non-fatal cardiovascular (CV) haemodialysis (HD). One-hundred-eighty-two end-stage renal disease (ESRD) undergoing HD at four dialysis clinics April 2015 provided written informed consent...
Abstract Background Accidental fall risk is high in patients undergoing maintenance hemodialysis. Falls are associated with fatal injury, comorbidities, and mortality. Risk assessment should be a primary component of prevention. This study investigated whether quadriceps muscle thickness measured using ultrasonography can predict injury among dialysis patients. Methods Using an observational cohort design, 180 ambulatory hemodialysis were recruited from 2015 to 2016 four clinics. The sum the...
Background While iron deficiency (ID) is a frequent cause of anemia in hemodialysis patients, the clinical impact ID without anemic level hemoglobin remains unclear. As such, this study was designed to clarify manifestations itself subjects on hemodialysis. Methods Maintenance patients achieving target levels (≥ 10.0g/dL) under treatment our clinic were stratified for comparison from three perspectives: (transferrin saturation [TSAT] < 20% or ferritin 100ng/mL) vs non-ID, TSAT (< ≥ 20%), and...
Abstract Background Difelikefalin, a potent and highly selective agonist of kappa opioid receptors, is used to treat moderate-to-severe pruritus in hemodialysis patients. Methods This was 52-week, open-label phase 3 trial following 6-week randomized double-blind placebo-controlled treatment period investigate the efficacy safety difelikefalin Japanese Having completed period, patients received 0.5 μg/kg three times per week intravenously for 52 weeks. Efficacies were assessed using numerical...
Introduction We examined the combined effect of erythropoietin (EPO) hyporesponsiveness and low handgrip strength (HGS) on prognosis patients undergoing hemodialysis (HD).Methods recruited with chronic kidney disease (CKD) Stage 5, who were HD at our dialysis clinic between January 2015 March (n = 182). Patients ≥20 years age had been for ≧3 months enrollment eligible inclusion. Seven treated epoetin-β pegol excluded. First, resistance index (ERI) HGS measured. The stratified by ERI 9.44...
【目的】維持血液透析患者において超音波エコーを用いた大腿前面筋厚測定の検者内信頼性, および男女別に大腿前面筋厚 (quadriceps femoris muscle thickness, 以下 : QT) と運動機能との関係を検討した. 【対象と方法】維持血液透析患者182例を対象に, 超音波エコーを用いたQT, 握力, 最大歩行速度を測定し, 筋厚測定の検者内信頼性は級内相関係数, 運動機能との関連を相関係数にて検討した. 【結果】筋厚測定の検者内信頼性は高く, 男性においてQTは握力, および最大歩行速度と有意な相関を認め, 女性においてQTは最大歩行速度と有意な相関を認めた. 【結語】超音波エコーによる維持血液透析患者の大腿前面筋厚測定は, 腎臓リハビリテーション領域における有用な指標になり得ることが示唆された.
Abstract Introduction: Accidental fall risk is high in patients undergoing maintenance hemodialysis. Falls are associated with fatal injury, comorbidities, and mortality. Risk assessment should be conducted as a primary intervention to prevent falls. This study investigated whether quadriceps muscle thickness measured using ultrasonography can prospectively predict injury among dialysis patients. Methods: Using an observational cohort design, 180 ambulatory hemodialysis during the period...
炭酸ランタン（L）とスクロオキシ水酸化鉄（S）のリン吸着効果と，制酸薬内服によるその変動について明らかにするため，本法人4施設の維持血液透析患者163名を対象として調査した．2017年4月1日から2019年12月31日の間に，前述2種類の薬剤いずれかを内服開始・増量した症例を対象とし，背景因子と薬剤変更前後の血清リン濃度の変化量を調査した．S開始・増量群では副作用による内服中止症例が多かったが，250 mgあたりのリン低下量はLに比して有意に大きかった．両薬剤の250 mgあたりのリン変化量を制酸薬の有無で比較すると，Lでは制酸薬内服症例の変化量が非内服症例の約66％と有意に小さかったが，Sでは有意差を認めなかった．Lのリン低下効力は制酸薬による胃内pH上昇で減弱するが，Sでは減弱しないことが示唆された．制酸薬内服患者におけるリン吸着薬の選択や結果の解釈には十分な注意が必要である．