Background Hysteroscopic polypectomy is a common method for treating endometrial polyps, but postoperative recurrence remains key concern. Recently, the levonorgestrel intrauterine system (LNG-IUS) has been suggested to reduce rate of polyps. This study aims investigate differences in rates and recurrence-free survival times between hysteroscopic alone combined with LNG-IUS, assess their impact on recurrence. Methods retrospectively included clinical data from 1,160 patients polyps 2020...

Gallbladder polyps (GBPs) are increasingly prevalent, with the majority being benign; however, neoplastic carry a risk of malignant transformation, highlighting importance accurate differentiation. This study aimed to develop and validate interpretable machine learning (ML) models accurately predict GBPs in retrospective cohort, identifying key features providing model explanations using Shapley additive (SHAP) method. A total 924 patients who underwent cholecystectomy between January 2013...

Background: Gallbladder cancer (GBC) is a rare but aggressive malignancy, often detected late due to early asymptomatic stages. Understanding cellular and molecular changes from normal tissue high-grade intraepithelial neoplasia (HGIN) invasive GBC vital for identifying biomarkers therapeutic targets. Methods: We performed single-cell RNA sequencing on 98,113 cells derived 2 adjacent tissues (NAT), HGIN, 6 samples. The diversity heterogeneity, particularly within epithelial immune cell...

Clinical guidelines recommend extended venous thromboembolism (VTE) prophylaxis for cancer patients after major gastrointestinal (GI) operations. However, adherence to the has been low, and clinical outcomes not well defined.This study retrospectively analyzed a random 10 % sample of 2009-2022 IQVIA LifeLink PharMetrics Plus database, an administrative claims database representative commercially insured population United States. The selected undergoing pancreas, liver, gastric, or esophageal...

Unmanaged hypertension in pregnancy is the second most common cause of direct maternal death and disproportionately affects women rural areas. While telehealth technologies have worked to reduce barriers healthcare, lack internet access has created new challenges. Cellular-enabled remote patient monitoring devices provide an alternative option for those without internet.

To evaluate the quality of Arkansas All-Payer Claims Database (APCD) for disparity research in persistent poverty areas by determining (1) its representativeness population, (2) variation county, and (3) differences coverage between other counties.

Hypertension affects 5-10% of pregnancies in the United States. Chronic hypertension during pregnancy can have a significant impact on maternal and neonatal outcomes, especially rural populations. Pregnancies complicated by are currently managed through frequent clinic visits or extended hospital stays. Cellular-enabled remote patient monitoring devices provide an alternative treatment method for women areas.This study aimed to measure feasibility satisfaction with using integrated model...

Falls pose a significant threat to older adults, resulting in injuries and mortality. Concurrently prescribed opioids gabapentin for pain management may increase fall risks patients. This study aimed estimate associated with the concurrent use of opioids, comparing them opioid monotherapy adults. A retrospective case-control 1,813 patients aged 65–89 on chronic therapy (2017–2020), excluding those history, analysis focused first occurrence. Logistic regression assessed association between...

The conscientious prescribing of antiemetics by chemotherapy-induced nausea and vomiting (CINV) risk was highlighted in the American Society Clinical Oncology (ASCO) "Choosing Wisely" recommendations. pharmacologic properties medical marijuana (MMJ) may allow for decreased incidence CINV; however, little is known about effects MMJ on use antiemetics. This study aimed to determine if cardholder status, which enables access MMJ, associated with antiemetic overuse among patients cancer.

e18812 Background: The conscientious prescribing of antiemetics by chemotherapy-induced nausea and vomiting (CINV) risk was highlighted in the American Society Clinical Oncology (ASCO) “Choosing Wisely” recommendations. pharmacologic properties medical marijuana (MMJ) increased availability through legislation may allow for decreased incidence CINV, however, little is known about effects MMJ on use antiemetics. objective thus to assess association between cardholder status Arkansas...

Background: Type 1 and type 2 diabetes during pregnancy requires intensive glucose monitoring to ensure optimal health outcomes for mothers infants. Standard practice includes patients their four six times a day using standard glucometer paper diary. Remote patient (RPM) offers an alternative method management. This study aimed at measuring the patient's satisfaction with feasibility of cellular-enabled RPM device management in pregnancies complicated by or diabetes. Methods: In...

Early identification of hereditary cancer risk would save lives, but genetic testing (GT) has been inadequate. We assessed i) trends for breast and ovarian (HBOC), Lynch syndrome, other GT ii) factors associated with receipt GT. used data from the Arkansas All-Payer Claims Database January 2013 through June 2018 (commercial, Medicaid), December 2017 (state employee), or 2016 (Medicare) identified enrollees ≥1 month enrollment. Using Current Procedural Terminology (CPT-4) codes, rates were...

Abstract Background Outpatient antibiotic (OP Abx) prescribing in adults Arkansas (AR) was among the country’s highest 2019. AR Medicaid analyzed prescription (Rx) claims data and communicated relative intensity as an informational metric to each patient-centered medical home (PCMH) beginning 2020. We describe Abx patterns calendar years 2019 2020, during COVID-19 pandemic. Methods Data from paid for OP Rxs adult patients attributed a PCMH practice > 6 months were analyzed. Annual Rx...