A5032986814- Cancer-related molecular mechanisms research
- Prostate Cancer Treatment and Research
- RNA Research and Splicing
Cleveland Clinic Lerner College of Medicine
2022
Antiandrogen strategies remain the prostate cancer treatment backbone, but drug resistance develops. We show that androgen blockade in leads to derepression of retroelements (REs) followed by a double-stranded RNA (dsRNA)-stimulated interferon response blocks tumor growth. A forward genetic approach identified H3K9 trimethylation (H3K9me3) as an essential epigenetic adaptation antiandrogens, which enabled transcriptional silencing REs otherwise stimulate signaling and glucocorticoid receptor...
Abstract Prostate cancer (PCa) is a major cause of mortality in the United States. Androgen receptor (AR) key transcriptional regulator for development and progression prostate cancer. deprivation therapy (ADT) with medical castration treatment second-generation anti-androgens such as enzalutamide abiraterone acetate are important treatments advanced Previous studies have shown resistance to develops through various alternative molecular mechanisms including AR gene amplification, mutations...