A5038364272- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Chemical Synthesis and Reactions
- Sulfur-Based Synthesis Techniques
- Synthesis and biological activity
- Oxidative Organic Chemistry Reactions
- Free Radicals and Antioxidants
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Organic Chemistry Cycloaddition Reactions
- Synthesis and Catalytic Reactions
- Asymmetric Synthesis and Catalysis
- Phenothiazines and Benzothiazines Synthesis and Activities
- Organic and Inorganic Chemical Reactions
- Biological Activity of Diterpenoids and Biflavonoids
- Synthesis of heterocyclic compounds
- Inorganic and Organometallic Chemistry
- Fluorine in Organic Chemistry
- Synthesis of Organic Compounds
- Natural product bioactivities and synthesis
- Vanadium and Halogenation Chemistry
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Biological Evaluation
- Carbohydrate Chemistry and Synthesis
- Synthesis and Reactions of Organic Compounds
- Chemical synthesis and alkaloids
Institute of Biology of Komi Scientific Centre
2012-2025
Ural Branch of the Russian Academy of Sciences
2011-2024
Russian Academy of Sciences
2015-2024
Institute of Chemistry, Komi Science Center
2012-2024
Institute of Geology, Komi Science Centre
2017-2023
A. N. Nesmeyanov Institute of Organoelement Compounds
2012
St. Petersburg Department of Steklov Institute of Mathematics
2011
ABSTRACT Here, we report a synthesis of fluoroquinolones carrying monoterpene moiety at the C7 position aromatic structure. The minimal inhibitory concentrations fluoroquinolone fused with trans ‐3‐hydroxy‐ cis ‐myrtanylamine 18 against Staphylococcus aureus (MSSA isolates) were two‐ to eightfold lower compared moxifloxacin, although fourfold higher MRSA isolates. (−)‐nopylamine 16 was four‐ less active on MSSA while had similar activity MRSA. Against biofilms, both and four times more than...
New unsymmetrical monoterpenylhetaryl disulfides based on heterocyclic and monoterpene thiols were synthesized for the first time in 48-88% yields. Hydrolysis of with fragments methyl esters 2-mercaptonicotinic acid was carried out 73-95% The obtained compounds evaluated antioxidant, antibacterial, antifungal activity, cytotoxicity mutagenicity.
Caryophyllane thioterpenoids were synthesized in 23 – 81% yields. The antioxidant properties of the obtained compounds various model systems found. It was revealed that 4,5‐epoxycaryophyll‐9‐ylmethanethiol has greatest activity. isomerism sesquiterpenic fragments shown to have a significant effect on biological activity compounds.
This paper presents the design and a comparative analysis of structural solvation factors on spectral biological properties BODIPY biomarker with thioterpene fragment. Covalent binding moiety to butanoic acid residue meso-substituted was carried out find membranotropic effect conjugate erythrocytes, assess possibilities its practical application in bioimaging. The molecular structure confirmed via X-ray, UV/vis-, NMR-, MS-spectra. It found that dye demonstrates high photostability...
Natural monoterpenes and their derivatives are widely considered as effective ingredients for the design production of new biologically active compounds with high antioxidant, antimicrobial anti-protozoa properties. In this study, we synthesized two series thiotherpenoids "sulfide-sulfoxide-sulfone", different bicyclic monoterpene skeleton (bornane pinane) structures. The effect obtained on platelet aggregation was investigated by using molecular docking technique. data revealed that all may...
The synthesis of sulfenimines and sulfinimines has been carried out with 10-hydroxyisocamphylthiol. configuration the compounds deduced by methods NMR, DFT calculations X-ray diffraction analysis. cytotoxic, antioxidant membrane-protective activity synthesized as well previously obtained based on 4-caranethiol have determined.
Abstract For the first time, dehydroabietic acid ethyl ester was used as initial material to produce corresponding at C‐18 position thioacetate, thiol, disulfide, sulfonic and sulfonyl chloride which open up prospects for synthesis of other polyfunctional compounds combining a biologically active dehydroabietane fragment with various pharmacophore groups. The optimal conditions were found directly oxidize dehydroabietanthiol sulfochloride using chlorine dioxide an oxidant in presence vanadyl...