A5081389573- Cytokine Signaling Pathways and Interactions
- Hippo pathway signaling and YAP/TAZ
- Multiple Sclerosis Research Studies
- Carcinogens and Genotoxicity Assessment
- Metabolomics and Mass Spectrometry Studies
- MicroRNA in disease regulation
- NF-κB Signaling Pathways
- Mitochondrial Function and Pathology
- Pneumonia and Respiratory Infections
- Inhalation and Respiratory Drug Delivery
- Adipose Tissue and Metabolism
- Virus-based gene therapy research
- DNA Repair Mechanisms
- Metabolism and Genetic Disorders
- Hematopoietic Stem Cell Transplantation
- Regulation of Appetite and Obesity
- Animal Genetics and Reproduction
- Peptidase Inhibition and Analysis
- Gout, Hyperuricemia, Uric Acid
- Plant Surface Properties and Treatments
- Molecular Biology Techniques and Applications
- Viral gastroenteritis research and epidemiology
- Systemic Lupus Erythematosus Research
University of Iowa
2015-2018
// Colleen A. Fullenkamp 1 , Sarah L. Hall Omar I. Jaber Brittany Pakalniskis Erica C. Savage Johanna M. Georgina K. Ofori-Amanfo Allyn Lambertz Stephanie D. Ivins Christopher S. Stipp 2 Benjamin J. Miller 3 Mohammed Milhem 4 and Munir R. Tanas Department of Pathology, University Iowa, Iowa City, IA, USA Biology, Orthopedics Rehabilitation, Internal Medicine, Correspondence to: Tanas, email: Keywords : TAZ, WWTR1, YAP, Hippo pathway, sarcoma, Pathology Section Received February 03, 2016...
Leptin contributes to the control of resting metabolic rate (RMR) and blood pressure (BP) through its actions in arcuate nucleus (ARC). The renin-angiotensin system (RAS) angiotensin AT1 receptors within brain are also involved RMR BP, but whether this regulation overlaps with leptin’s is unclear. Here, we have demonstrated selective requirement AT1A receptor leptin-mediated RMR. We observed that colocalized leptin (LEPRs) ARC. Cellular coexpression LEPR was almost exclusive ARC occurred...
Ataxia telangiectasia (AT) is a progressive multisystem disorder caused by mutations in the AT-mutated (ATM) gene. AT neurodegenerative disease primarily characterized cerebellar degeneration children leading to motor impairment. The progresses with other clinical manifestations including oculocutaneous telangiectasia, immune disorders, increased susceptibly cancer and respiratory infections. Although genetic investigations physiological models have established linkage of ATM onset,...
Genetically engineered pigs are increasingly recognized as valuable models for the study of human disease. Immunohistochemical cellular markers disease is an important tool investigation these novel so to evaluate genotype and treatment differences. Even so, there remains a lack validated pig tissues that can serve translational link in organs such lung. Herein, we inflammation (cluster differentiation [CD]3, CD79a, B cell lymphoma [BCL] 6, ionized calcium-binding adapter molecule [IBA]1,...
Experimental autoimmune encephalomyelitis (EAE) is a well-established mouse model for multiple sclerosis and characterized by infiltration of mononuclear cells demyelination within the central nervous system along with clinical symptoms paralysis. EAE multifocal random disease, which sometimes makes histopathologic analysis lesions difficult as it may not be possible to predict where will occur, especially when evaluating cross sections spinal cord. Consequently, easily missed due limited...
// Nicole M. Merritt 1 , Colleen A. Fullenkamp Sarah L. Hall Qining Qian 2 Chandni Desai Jon Thomason Allyn Lambertz Adam J. Dupuy 3 Benjamin Darbro and Munir R. Tanas Department of Pathology, University Iowa, Iowa City, IA, USA Pediatrics, Anatomy Cell Biology, Correspondence to: Tanas, email: munir-tanas@uiowa.edu Keywords: Hippo pathway; sarcoma; TAZ; YAP; epigenetics Abbreviations: TAZ: transcriptional coactivator with PDZ-binding motif; YAP: yes associated protein; AZA: 5-azacytidine;...
Previously we have shown that loss of non-canonical NF-κB signaling impairs self-renewal hematopoietic stem/progenitor cells (HSPCs). This prompted us to investigate whether persistent activation the will supportive effects on HSPC self-renewal. NF-κB-inducing kinase (NIK) is an important mainly activates pathway through directly phosphorylating IKKα. In contrast our expectations, constitutive NIK in system leads bone marrow (BM) failure and postnatal lethality due intrinsic impairment...
The Comparative Pathology Laboratory (CPL) at the University of Iowa is affiliated with both a teaching hospital and research university, which provides opportunity to work tissues from humans variety animals, including mice, rats, ferrets, rabbits, sheep pigs. CPL has developed procedures for immunohistochemical (IHC) antibodies on organisms antibody not previously been validated. In many instances, non‐standard are referenced datasheets. Peer‐reviewed journal articles referenced, but...