A5013379174- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Antibiotic Resistance in Bacteria
- Diagnosis and treatment of tuberculosis
- COVID-19 diagnosis using AI
- Pneumonia and Respiratory Infections
- Economic and Technological Developments in Russia
- Evolution and Genetic Dynamics
- Biochemical and Molecular Research
- Biosimilars and Bioanalytical Methods
- Global Socioeconomic and Political Dynamics
- Economic Sanctions and International Relations
- Clostridium difficile and Clostridium perfringens research
Swiss Tropical and Public Health Institute
2019-2025
University of Basel
2019-2025
National Center for Tuberculosis and Lung Disease
2019-2025
Multidrug-resistant tuberculosis (MDR-TB) is among the most frequent causes of death due to antimicrobial resistance. Although only 3% global TB cases are MDR, geographical hotspots with up 40% MDR-TB have been observed in countries former Soviet Union. While quality control and patient-related factors known contributors such hotspots, role pathogen remains unclear. Here we show that country Georgia, a hotspot MDR-TB, MDR Mycobacterium strains lineage 4 (L4) transmit less than their...
Tuberculosis (TB) remains a major public health concern. Improving TB control programmes and treatment success rates requires deeper understanding of the factors that determine disease presentation patient outcomes. While demographic clinical influencing outcomes are well documented, role bacterial genetics limited. In this study, we analyzed Mycobacterium tuberculosis complex (MTBC) genomes associated data from 4,536 patients in country Georgia covering period 13 years. Multivariable...
Abstract Background Xpert MTB/XDR (Cepheid) is recommended by the World Health Organization for drug susceptibility testing in patients with tuberculosis, potential rapid detection of isoniazid and fluoroquinolone resistance. However, diagnostic accuracy clinical utility a programmatic setting are unknown. Methods We evaluated rifampicin-resistant pulmonary tuberculosis during implementation Georgia between July 2022 August 2024, using phenotypic (DST) as reference standard. Results An...
Introduction Recurrent tuberculosis (TB) is one of the main challenges in TB control. Genotyping based on Mycobacterial Interspersed Repetitive Units–Variable Tandem Repeats (MIRU-VNTR) has been widely used to differentiate between relapse and reinfection, which are two causes recurrent TB. There a lack data regarding recurrence Georgia, while differentiating reinfection plays key role defining appropriate interventions, required genotyping methodologies have not implemented. The objective...
Abstract Multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant (XDR) TB are threatening global control. The World Health Organization has recently endorsed new regimens for the treatment of MDR-TB that rely on repurposed drugs bedaquiline, pretomanid linezolid with or without moxifloxacin (BPaL(M)). As BPaL(M) is being rolled-out, resistance to these already emerging, leading acquired XDR-TB. Importantly, instances transmitted XDR-TB have been reported. spread highly M....
Abstract Differential culturable bacteria grow in liquid culture medium but are unable to form colonies on solid medium. Differentially Mycobacterium tuberculosis (Mtb) bacteria, have been found (TB) patient sputa. We hypothesized that antibiotic treatment can induce differential culturability Mtb. investigated the effect of exposure TB drugs Mtb using clinical samples from an ongoing cohort and by conducting several vitro experiments with a diverse set strains. In patients, serial sputa...
Background: Xpert MTB/XDR (Cepheid, USA) is recommended for drug susceptiblity testing in patients with tuberculosis (TB) by the World Health Organization (WHO) potential rapid detection of isoniazid and fluoroquinolones resistance. However, diagnostic accuracy clinical utility a programmatic setting are unknown. Methods: We evaluated XDR rifampicin-resistant pulmonary TB during implementation Georgia between July 2022 August 2024, using phenotypic susceptibility (pDST) as reference...
Introduction Mycobacterial Interspersed Repetitive Units–Variable Tandem Repeats (MIRU-VNTR) typing has been widely used for molecular epidemiological studies of tuberculosis (TB). However, genotyping tools Mycobacterium (Mtb ) may be limiting in some settings due to high cost and workload. In this study developed a customized stepwise MIRU-VNTR that prioritizes discriminatory loci validated method using penitentiary system cohort the country Georgia. Methods We previously generated dataset...