A5087384373- SARS-CoV-2 detection and testing
- Biosensors and Analytical Detection
- Tuberculosis Research and Epidemiology
- COVID-19 diagnosis using AI
- SARS-CoV-2 and COVID-19 Research
- Advanced biosensing and bioanalysis techniques
- Traditional Chinese Medicine Studies
- Pneumonia and Respiratory Infections
- Cell Adhesion Molecules Research
- Receptor Mechanisms and Signaling
- Digital Imaging for Blood Diseases
- Mycobacterium research and diagnosis
Heidelberg University
2022-2025
University Hospital Heidelberg
2022-2025
German Center for Infection Research
2024-2025
Heidelberg University
2023
Başkent University Hospital
2023
Universitat de Barcelona
2023
Barcelona Institute for Global Health
2023
European Respiratory Society
2023
BackgroundNon-sputum-based triage tests for tuberculosis are a priority ending tuberculosis. We aimed to evaluate the diagnostic accuracy of late-prototype Xpert MTB Host Response (Xpert HR) blood-based assay.MethodsWe conducted prospective study among outpatients with presumed in outpatient clinics Viet Nam, India, Philippines, Uganda, and South Africa. Eligible participants were aged 18 years or older reported cough lasting at least 2 weeks. excluded those receiving treatment preceding 12...
Abstract Background Xpert MTB/XDR (Cepheid) is recommended by the World Health Organization for drug susceptibility testing in patients with tuberculosis, potential rapid detection of isoniazid and fluoroquinolone resistance. However, diagnostic accuracy clinical utility a programmatic setting are unknown. Methods We evaluated rifampicin-resistant pulmonary tuberculosis during implementation Georgia between July 2022 August 2024, using phenotypic (DST) as reference standard. Results An...
Summary Background Swab-based molecular platforms that enable testing of both sputum (via swabs swirled in sputum) and tongue are emerging as a promising option for more accessible lower cost tuberculosis (TB). We conducted multi-country evaluation two novel swab-based tests: Molbio Truenat MTB Ultima (MTB Ultima) Pluslife MiniDock Test (MiniDock MTB). Methods Consecutive people ≥12 years old with presumptive TB were enrolled at outpatient health centers India, Uganda, Vietnam. collected...
Rationale: C-reactive protein (CRP)-based tuberculosis (TB) screening is recommended for people with HIV (PWH). However, its performance among without and in diverse settings unknown. Objectives: In a multi-country study, we aimed to determine whether CRP meets the minimum accuracy targets (sensitivity ≥90%, specificity ≥70%) an effective TB test. Methods/Measurements: Consecutive outpatient adults cough ≥2 weeks from five endemic countries Africa Asia had baseline blood collected...