A5090017630- Pneumonia and Respiratory Infections
- Tuberculosis Research and Epidemiology
- Infant Nutrition and Health
- Gut microbiota and health
- Milk Quality and Mastitis in Dairy Cows
- Breastfeeding Practices and Influences
- Enterobacteriaceae and Cronobacter Research
- Respiratory viral infections research
- COVID-19 diagnosis using AI
- Pediatric health and respiratory diseases
- SARS-CoV-2 and COVID-19 Research
- Biosimilars and Bioanalytical Methods
- Diagnosis and treatment of tuberculosis
- Mycobacterium research and diagnosis
South African Medical Research Council
2022-2025
Stellenbosch University
2022-2025
University of Cape Town
2018-2020
BackgroundNon-sputum-based triage tests for tuberculosis are a priority ending tuberculosis. We aimed to evaluate the diagnostic accuracy of late-prototype Xpert MTB Host Response (Xpert HR) blood-based assay.MethodsWe conducted prospective study among outpatients with presumed in outpatient clinics Viet Nam, India, Philippines, Uganda, and South Africa. Eligible participants were aged 18 years or older reported cough lasting at least 2 weeks. excluded those receiving treatment preceding 12...
<title>Abstract</title> Introduction: Non-sputum tests for people attending primary care with symptoms of tuberculosis (TB) are a global priority. Methods: We performed cross-sectional two-centre diagnostic accuracy study next-generation urine lipoarabinomannan assay (Biopromic TB LAM, BP-LAM) and the lateral flow Determine LAM Ag (LF-LAM) on from 629 adults presumptive pulmonary (315 TB) in South Africa Uganda. An extended sputum microbiological reference standard (eMRS) was used and,...
Culture-independent molecular techniques have advanced the characterization of environmental and human samples including milk (HM) bacteriome. However, extraction high-quality genomic DNA that is representative bacterial population in crucial. Lipids removal from HM prior to common practice, but this may influence detected. The objective study was compare four commercial kits lipid relation profiles. Four kits, QIAamp® Microbiome Kit, ZR Fungal/Bacterial MiniPrep™, QIAsymphony DSP Kit...
The human breast milk (HBM) bacteriome is an important, continuous source of microbes to the neonate in early life, playing important role shaping infant’s intestinal bacteriome. Study composition HBM emerging area research, with little information available, particularly from low- and middle-income countries. aim this study was characterize diversity bacterial communities samples collected between 6–10 weeks postpartum lactating South African women potential influencing factors Using 16S...
<title>Abstract</title> <underline><italic>Introduction:</italic></underline><italic/>Non-sputum tuberculosis (TB) tests are a global priority. Next-generation urine lipoarabinomannan (LAM) diagnostics with utility beyond only people advanced immunosuppression urgently needed.<underline><italic>Methods:</italic></underline><italic/>We performed two-centre diagnostic accuracy study to evaluate the performance of Biopromic TB LAM assay (BP-LAM assay) and lateral flow Determine Ag test (LF-LAM)...