A5024827140- Air Quality and Health Impacts
- Carcinogens and Genotoxicity Assessment
- Histone Deacetylase Inhibitors Research
- Indoor Air Quality and Microbial Exposure
- Redox biology and oxidative stress
- Biochemical effects in animals
- Smoking Behavior and Cessation
- Epigenetics and DNA Methylation
- Retinoids in leukemia and cellular processes
- Cancer Research and Treatments
- Cancer-related gene regulation
- Adipose Tissue and Metabolism
- Sirtuins and Resveratrol in Medicine
- Advanced Chemical Sensor Technologies
- Sulfur Compounds in Biology
- Amino Acid Enzymes and Metabolism
- Genomics, phytochemicals, and oxidative stress
Massachusetts Institute of Technology
2013
Aberrant protein modifications play an important role in the pathophysiology of many human diseases, terms both dysfunction physiological and formation pathological by reaction proteins with endogenous electrophiles. Recent studies have identified a chemical homolog lysine acetylation, N6-formyllysine, as abundant modification histone chromatin proteins, one possible source which is 3′-formylphosphate residues from DNA oxidation. Using new liquid chromatography-coupled to tandem mass...
With formaldehyde as the major source of endogenous N⁶-formyllysine protein adducts, we quantified and exogenous in nasal epithelium rats exposed by inhalation to 0.7, 2, 5.8, 9.1 ppm [¹³C²H₂]-formaldehyde using liquid chromatography-coupled tandem mass spectrometry. Exogenous was detected epithelium, with concentration-dependent formation total well fractionated (cytoplasmic, membrane, nuclear) proteins, but not lung, liver, or bone marrow. Endogenous adducts dominated at all exposure...
Exposure to both endogenous and exogenous formaldehyde has been established be carcinogenic, likely by virtue of forming nucleic acid proteins adducts such as N