A5101913983- Reproductive biology and impacts on aquatic species
- Fish Ecology and Management Studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Mesenchymal stem cell research
- Aquaculture disease management and microbiota
- Congenital heart defects research
- Animal Genetics and Reproduction
- Renal Diseases and Glomerulopathies
- Diabetic Foot Ulcer Assessment and Management
- Pancreatic function and diabetes
- Wound Healing and Treatments
- Genetic and Kidney Cyst Diseases
- Aquaculture Nutrition and Growth
- Fish Biology and Ecology Studies
- Cardiomyopathy and Myosin Studies
- Protist diversity and phylogeny
- Zebrafish Biomedical Research Applications
- Animal Behavior and Reproduction
- Cellular transport and secretion
- Insect Pest Control Strategies
- Cardiac electrophysiology and arrhythmias
- Renal and related cancers
- Reproductive Biology and Fertility
- Marine and fisheries research
- Artificial Intelligence in Healthcare
Duke University
2024-2025
University of Helsinki
2014-2023
Biocenter Finland
2023
Ravenshaw University
2021
Central Institute of Freshwater Aquaculture
2005-2019
University of Eastern Finland
2018
Utkal University
2013
Regional Plant Resource Centre
2009
Bone marrow (BM)-derived mesenchymal stem cells (MSCs) represent a promising population for supporting new concepts in cellular therapy. This study was undertaken to assess the efficacy and feasibility of autologous BM-derived MSCs treatment chronic nonhealing ulcers (diabetic foot Buerger disease) lower extremities. A total 24 patients with limb were enrolled randomized into implant control groups. In group, received cultured along standard wound dressing; group only dressing regimen,...
Metformin, the first-line drug to treat type 2 diabetes (T2D), inhibits mitochondrial glycerolphosphate dehydrogenase in liver suppress gluconeogenesis. However, direct target and underlying mechanisms by which metformin increases glucose uptake peripheral tissues remain uncharacterized. Lipid phosphatase Src homology domain-containing inositol-5-phosphatase (SHIP2) is upregulated diabetic rodent models suppresses insulin signaling reducing Akt activation, leading resistance diminished...
Focal Segmental Glomerulosclerosis (FSGS) is a histologic lesion caused by variety of injurious stimuli that lead to dysfunction/loss glomerular visceral epithelial cells (i.e. podocytes). Pathogenic mutations in CRB2, encoding the type 1 transmembrane protein crumbs homolog-2, have been shown cause early-onset corticosteroid-resistant nephrotic syndrome (SRNS)/FSGS. Here, we identified 2-generation Indian kindred (DUK40595) with biopsy-proven SRNS/FSGS compound heterozygous mutation CRB2...
Novel physiological challenges in different environments can promote the evolution of divergent phenotypes, either through plastic or genetic changes. Environmental salinity serves as a key barrier to distribution nearly all aquatic organisms, and species diversification is likely be enabled by adaptation alternative osmotic environments. The threespine stickleback (Gasterosteus aculeatus) euryhaline with populations found both marine freshwater It has evolved highly locally adapted...
Calcium channels are necessary for cardiac excitation-contraction (E-C) coupling, but Ca2+ channel composition of fish hearts is still largely unknown. To this end, we determined transcript expression in the heart zebrafish (Danio rerio), a popular model species. Altogether, 18 α-subunit genes were expressed both atrium and ventricle. Transcripts 7 L-type (Cav1.1a, Cav1.1b, Cav1.2, Cav1.3a, Cav1.3b, Cav1.4a, Cav1.4b), 5 T-type (Cav3.1, Cav3.2a, Cav3.2b, Cav3.3a, Cav3.3b) 6 P/Q-, N- R-type...
The conserved septin family of filamentous small GTPases plays important roles in mitosis, cell migration, and morphogenesis by forming scaffolds diffusion barriers. Recent studies tissue culture cells indicate that a complex 2, 7 9 is required for ciliogenesis cilia function, but function vertebrate organs vivo not understood. We show sept7b expressed ciliated different tissues early zebrafish development. Knockdown morpholino antisense oligonucleotides caused misorientation basal bodies...
Myofibrils made up of actin, myosin, and associated proteins generate the contractile force in muscle, and, consequently, mutations these may lead to heart failure. Septins are a conserved family small GTPases that associate with actin filaments, microtubules, cellular membranes. Despite importance septins cytoskeleton organization, their role cardiomyocyte organization function is poorly characterized. Here, we show septin 7 expressed both embryonic adult zebrafish hearts elucidate...
The adapter protein CD2-associated (CD2AP) functions in various signaling and vesicle trafficking pathways, including endosomal sorting and/or degradation pathways. Here, we investigated the role of CD2AP insulin-dependent glucose transporter 4 (Glut4, also known as SLC2A4) uptake. Glucose uptake was attenuated CD2AP(-/-) podocytes compared with wild-type basal state, failed to increase response insulin. Live-cell imaging revealed dynamic HA-Glut4-GFP podocytes, whereas clustered...
Rosuvastatin based indoles showed anti-proliferative and apoptotic activities an increase of <italic>p21</italic> mRNA expression levels in zebrafish larvae.
Exposure to large concentrations of organic PAH (polycyclic aromatic hydrocarbon) compound naphthalene can potentially accumulate inside the body, damage cells and causes serious health issues. The current understanding exposure many food fish species is limited. For a comprehensive toxicity health, dose dependent was carried out in Anabas testudineus, an important Asia. Fish were exposed sublethal (4.2, 4.4, 4.6, 4.8 5 mg L−1) for period 72 h. Activity analysis lipid peroxidation...
This study aimed at developing a suitable cryopreservation protocol for embryonic stem (ES)-like cells of tiny freshwater fish Leopard danio (Brachydanio frankei). Embryonic derived from blastomeres the early blastulae stage embryo were cultured in vitro medium containing Leibowitz-15 supplemented with 10% foetal bovine serum, leopard extract, sodium bicarbonate, selenite, basic fibroblast growth factor, epidermal factor and leukaemia inhibitory factor. The ES-like showed properties similar...
The effects of extender composition, cryoprotectant concentration and freezing thawing on the fertilization efficiency cryopreserved spermatozoa Puntius gonionotus were evaluated. Computer-aided motility analysis semen was conducted to check suitability for cryopreservation after mixing with different extenders cryoprotective agents (CPAs). Extender-4 an osmolality 260 mOsmol kg−1and pH 7.6 used study. Among CPAs, dimethyl sulphoxide (DMSO) least toxic more than 60% achieved when at 1.4 M 0...
Abstract Protection or restoration of pancreatic β-cell mass as a therapeutic treatment for type 1 diabetes requires understanding the mechanisms that drive specification and development endocrine cells. Septins are filamentous small GTPases function in regulation cell division, cytoskeletal organization membrane remodeling involved various tissue-specific developmental processes. However, their role differentiation remains unknown. Here we show by functional manipulation techniques...
Background: Ladybird beetles are great bio-control agents and campodeiform grubs of these little predators able to devour aphids in a voracious fashion. They feed on wide array aphid species most noticeably the infamous black or cowpea Aphis craccivora (Koch). Methods: The growth feeding potential C. sexmaculata were studied laboratory Department Entomology, Faculty Agricultural Sciences (Institute Sciences), SOA Deemed be University, Bhubaneswar, India at four different temperatures 20°C,...
Abstract Focal Segmental Glomerulosclerosis (FSGS) is a histologic lesion caused by variety of injurious stimuli that lead to dysfunction/loss glomerular visceral epithelial cells (i.e. podocytes). Pathogenic mutations in CRB2, encoding the type 1 transmembrane protein Crumb 2 Homolog Protein, have been shown cause early-onset corticosteroid-resistant nephrotic syndrome (SRNS)/FSGS. Here, we identified 2-generation East Asian kindred (DUK40595) with biopsy-proven SRNS/FSGS compound...
Introduction: An altered serum lipid profile and lipoprotein levels are major modifiable risk factors for hypertension. Apolipoprotein A1 B100 (ApoA1 ApoB100) the chief structural proteins of High-density Lipoprotein Cholesterol (HDL-C) Low-density (LDL-C), respectively. The level ApoB in represents overall atherogenicity, whereas ApoA1 can indicate total antiatherogenicity. Aim: To evaluate first-degree relatives individuals with essential Materials Methods: This cross-sectional...
Macrobrachium gangeticum (Bate) are commercially valuable prawns that broadly distributed in the Ganga river flows from northern to eastern India. We studied embryonic development cleavage (blastomeres), segmentation, formation of optic vesicle, eye pigment larva formation, as these data largely unknown this species. conducted study using mature M. broodstock placed freshwater tanks. Just after spawning, females were kept separate aerated tanks, where fecundity was estimated total number...