As one of the most serious complications sepsis, sepsis-associated encephalopathy has not been effectively treated or prevented. Exosomes, as a new therapeutic method, play protective role in neurodegenerative diseases, stroke and traumatic brain injury recent years. The purpose this study was to investigate exosomes glutamate (Glu)-induced neuronal injury, explore its mechanism, providing ideas for treatment encephalopathy. neuron damage model induced by Glu established, metabolomics...

• Vogt-Koyanagi-Harada syndrome, or the uveomeningitis is one of most commonly identified types endogenous uveitis diagnosed in China. Because its incidence higher Orientals than whites, immunogenetic backround may be an important factor incidence. We performed HLA-A, -B, and -DR typing on 25 patients with syndrome 65 healthy control subjects from Han Chinese population. The results showed that HLA-DR4 -Dw53 were closely associated (<i>P</i>&lt;.001 [relative risk = 16.0] and<i>P</i>&lt;.001...

Advanced glycation end-products (AGEs) are a group of heterogeneous compounds formed in heat-processed foods and proven to be detrimental human health. Currently, there is no comprehensive database for AGEs that covers the entire range food categories, which limits accurate risk assessment dietary diseases. In this study, we first established an isotope dilution UHPLC-QqQ-MS/MS-based method simultaneous quantification 10 major foods. The contents these were detected 334 covering all main...

Microplastics (MPs) are of increasing concern due to their role as reservoirs for antibiotic resistance genes (ARGs) and pathogens. To date, few studies have explored the influence anthropogenic activities on ARGs mobile genetic elements (MGEs) within various riverine MPs, in comparison natural counterparts. Here an in-situ incubation was conducted along heavily anthropogenically-impacted Houxi River characterize geographical pattern resistome, mobilome pathogens inhabiting MPs-...

High-fat diets (HFDs) predispose to obesity and liver dysfunctions, α-dicarbonyl compounds (α-DCs) present in highly processed foods are also implicated relevant pathological processes. However, the synergistic harmful effects of α-DCs co-administered with HFDs remain be elucidated. In this study, 6-week-old C57BL/6 mice were fed a HFD 0.5% methylglyoxal (MGO)/glyoxal (GO) water for 8 weeks, multi-omics approaches employed investigate underlying toxicity mechanisms. The results demonstrated...

18F-2-fluoro-2-deoxy-d-glucose ([18F]FDG) has been the most used positron emission tomography imaging agent for clinical applications. Single photon computed (SPECT) is cheaper and more widely diagnostic use, but there no SPECT tumor applications comparable to [18F]FDG. Mannose a C2 epimer of glucose can also be transported into cells via transporters (GLUTs). To develop novel with satisfactory uptake tumor/nontarget ratios, here mannose derivative (CN7DM) was synthesized radiolabeled...

The specific expression of prostate-specific membrane antigen (PSMA) makes it an ideal target for the diagnosis and treatment prostate cancer. Currently, many

Advanced glycation end-products (AGEs) are a group of heterogeneous compounds formed during the Maillard Reaction (MR) and have been proven to be detrimental human health. In addition thermally processed foods, digestive tract may an additional site for exogenous AGE formation since MR would possibly occur between (oligo-)peptides, free amino acids, reactive products (MRPs) such as α-dicarbonyl (α-DCs) along digestion. this study, through establishing simulated gastrointestinal (GI) model...

When developing novel radiopharmaceuticals, a linker moiety between the chelator and targeting vector can have crucial influence on adjusting affinity of tracer its biodistribution in organisms. To develop 99mTc-labelled hypoxia imaging radiotracers, this study, five isocyanide-containing 2-nitroimidazole derivatives with different linkers (L1, L2, L3, L4 L5) were synthesised radiolabelled technetium-99m to obtain stable 99mTc-complexes ([99mTc]Tc-L1, [99mTc]Tc-L2, [99mTc]Tc-L3, [99mTc]Tc-L4...

Cutaneous exposure to food allergens through a disrupted skin barrier is recognized as an important cause of allergy, and the cutaneous sensitized mouse model has been established investigate relevant allergic disorders. However, role different genetic backgrounds mice on immune responses upon epicutaneous sensitization largely unknown. In this study, two strains mice, <i>i.e.</i>, BALB/c C57BL/6 were epicutaneously with ovalbumin atopic dermatitis (AD)-like lesions, followed by intragastric...

Apostichopus japonicus and Parastichopus californicus are two of the most important profitable commercial sea cucumbers along North Pacific coast. This study compared body wall production rate (BWPR), proximate composition, amino acid, fatty trace element vitamin nonspecific immune enzyme activities A. P. cultured in an artificial pond.The BWPR, crude fat ash content walls showed remarkable differences (P < 0.05). For 18 acids tested, contents 15 were significant 0.05) between species,...

We introduce a novel fast-reciprocating probe head installed on the EAST (Experiment Advanced Superconducting Tokamak) containing 12 graphite tips. This allows us to measure variety of plasma parameters such as density, temperature, and space potential in scrape-off layer (SOL). will also acquire data at high frequency thus measuring ion saturation current, Isat, floating potential, Vf, average fluctuating values. Moreover, with poloidally separated tips, we poloidal electric field, Eθ, two...

Microcirculation abnormality in septic shock is closely associated with organ dysfunction and mortality rate. It was hypothesized that the arterial blood glucose interstitial fluid (ISF) difference (GA−I) as a marker for assessing microcirculation status can effectively evaluate severity of disturbance patients shock. The present observational study enrolled admitted to treated intensive care unit (ICU) tertiary teaching hospital. parameters reflecting tissue perfusion, including lactic acid...

Soot particles from the combustion of hydrocarbon fuels are main source air fine and they also an important factor reducing efficiency. As one their major precursor, acetylene (C&lt;sub&gt;2&lt;/sub&gt;H&lt;sub&gt;2&lt;/sub&gt;) plays role in forming soot. So simultaneous detecting soot particle C&lt;sub&gt;2&lt;/sub&gt;H&lt;sub&gt;2&lt;/sub&gt; is significant studying mechanism formation. In this work, a sensor for developed by using single DFB diode laser with wavelength near 1540 nm. The...

Sepsis is a life-threatening organ dysfunction caused by infection that lead to dysregulation of the host response. and septic shock with high mortality threaten human health at present, which are important medical problems. Early diagnosis treatment decision-making for sepsis still need be improved. Exosomes extracellular vesicles diameter 30-150 nm formed fusion multi-vesicle bodies cell membranes. can effectively transport variety bioactive substances such as proteins, lipids, RNA, DNA,...

To develop novel radiolabeled amino acid tumor imaging agents, 4-methoxy-L-phenylalanine dithiocarbamate (MOPADTC) was synthesized successfully, and two kinds of 99mTc-labeled complexes ([99mTc]TcN-MOPADTC [99mTc]TcO-MOPADTC) with high radiochemical purities (RCP &gt; 95%) were obtained. The in vitro stability partition coefficient determined, the results show that both these have good stability; [99mTc]TcO-MOPADTC is hydrophilic, while [99mTc]TcN-MOPADTC slightly lipophilic. biodistribution...

Currently, there is no comprehensive database for advanced glycation end-products (AGEs) in foods that covers the entire range of food categories, which limits accurate risk assessment dietary AGEs. Here, we first established an isotope-dilution UHPLC-QqQ-MS/MS-based method simultaneous quantification 10 major AGEs foods. The contents these were detected 334 covering all main groups consumed Western and Chinese populations. Nε-carboxymethyllysine, methylglyoxal-derived hydroimidazolone...