About
Contact & Profiles
A5069167879
Research Areas
- Synthesis and biological activity
- Cancer therapeutics and mechanisms
- Computational Drug Discovery Methods
Al-Azhar University
2022
An essential target for COVID-19 is the main protease of SARS-CoV-2 (Mpro). With objective targeting this receptor, a novel set pyrido[1,2-a]pyrrolo[2,3-d]pyrimidines with terminal carboxamide fragments was designed, synthesized, and considered as an initial motif creation effective pan-coronavirus inhibitors. Accordingly, nine derivatives (21-29) have been introduced in vitro assay to evaluate their antiviral activity cytotoxicity effect against virus using Vero cells. The obtained data...
10.1039/d2ra04015h
article
EN
cc-by-nc
RSC Advances
2022-01-01
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