A5007304510- Medication Adherence and Compliance
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- Pharmaceutical Practices and Patient Outcomes
- Pharmaceutical studies and practices
- Health Systems, Economic Evaluations, Quality of Life
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Healthcare Policy and Management
- Pneumocystis jirovecii pneumonia detection and treatment
- Pharmaceutical Economics and Policy
- HIV Research and Treatment
- Heart Failure Treatment and Management
- Economic and Financial Impacts of Cancer
- Renal Transplantation Outcomes and Treatments
- Cystic Fibrosis Research Advances
- Eosinophilic Esophagitis
- Pregnancy and Medication Impact
- Healthcare cost, quality, practices
- Health Literacy and Information Accessibility
- Chronic Disease Management Strategies
- Transplantation: Methods and Outcomes
- Adolescent and Pediatric Healthcare
- Adolescent Sexual and Reproductive Health
- Immunodeficiency and Autoimmune Disorders
Walgreens (United States)
2013-2024
Deerfield (United States)
2013-2024
University of Washington Medical Center
2021
University of Washington
2020
Walgreens Boots Alliance (United States)
2018
Bristol-Myers Squibb (Germany)
2017
Background: A benchmark of near-perfect adherence (≥95%) to antiretroviral therapy (ART) is often cited as necessary for HIV viral suppression. However, given newer, more effective ART medications, the threshold suppression may be lower. We estimated minimum level achieve Settings: The Patient-centered Care Model demonstration project. Methods: Adherence was calculated using proportion days covered measure 365-day period before each load test result, and grouped into 5 categories (<50%,...
Abstract Introduction Persistence on preexposure prophylaxis for HIV prevention (PrEP) medication has rarely been reported periods greater than one year, or in real‐world settings. This study used pharmacy fill records PrEP users from a national chain to describe persistence over two‐year period, and explore correlates with setting. Methods We analysed de‐identified of 7148 eligible individuals who initiated 2015 at pharmacy. A standard algorithm was employed identify TDF‐FTC use indication....
Background:In an attempt to contain Medicaid pharmacy costs, nearly all states impose dispensing limits on medication days' supply.Although longer supply appears increase the potential for wastage, previous studies suggest that it may also decrease expenditures by reducing fees and drug ingredient costs.This study was conducted determine whether 90day refills at community pharmacies could improve adherence, minimize control costs. Methods:This retrospective observational used California...
The purpose of this retrospective, longitudinal study was to assess associations between modifiable health risks and workplace absenteeism presenteeism estimate lost productivity costs. Across the 4-year period (2007–2010), 17,089 unique employees from a large US computer manufacturer with highly technical workforce completed at least 1 risk assessment. Generalized estimating equation models were used mean population-level for 11 adjust 9 sociodemographic employment-related factors. Because...
The effect of a collaborative pharmacist-hospital care transition program on the likelihood 30-day readmission was evaluated.This retrospective cohort study conducted in two acute hospitals within same hospital system southeastern United States. One initiated January 2011; other did not have such program. All patients who were discharged from either to home 1, 2010, through December 31, 2011, included study. key components bedside delivery postdischarge medications and follow-up telephone...
Abstract Background Human immunodeficiency virus (HIV) viral suppression (VS) decreases morbidity, mortality, and transmission risk. Methods The Patient-centered HIV Care Model integrated community-based pharmacists with medical providers required them to share patient clinical information, identify therapy-related problems, develop action plans. Proportions adherent antiretroviral therapy (proportion of days covered [PDC] ≥90%) virally suppressed (HIV RNA &lt;200 copies/mL), before...
Health care systems in many countries are using the "Triple Aim"—to improve patients' experience of care, to advance population health, and lower per capita costs—as a focus for improving quality. Population strategies addressing Triple Aim becoming increasingly prevalent developed countries, but ultimately success will also require targeting specific subgroups individuals. Certain events, which we call Fail" constitute simultaneous failure meet all three goals. The risk experiencing...
Poor retention in HIV care is associated with higher morbidity and mortality greater risk of transmission. The Patient-Centered Care Model (PCHCM) integrated community-based pharmacists medical providers. model required sharing patient clinical information collaborative therapy-related action planning. proportion persons retained (≥1 visit each 6-month period a 12-month measurement ≥60 days between visits), pre- post-PCHCM implementation, was modeled using log binomial regression. Factors...
Although annual influenza vaccination could decrease the significant economic and humanistic burden of in United States, immunization rates are below recommended levels, concerns remain whether programs can be cost beneficial. The research objective was to compare benefit various strategies from employer, employee, societal perspectives. An actuarial model developed based on published literature estimate costs benefits programs. Useful features included customization by population age...
Hypertension, hyperlipidemia, and type 2 diabetes (T2D) are 3 of the most common chronic conditions, but related medication adherence rates far below 80%. Consequences poor include high health care utilization/costs increased mortality. There is accumulating evidence in support benefits affording pharmacists opportunity to practice at full scope their licensure by engaging patients' clinical care.
To compare medication adherence, pulmonary exacerbations, healthcare utilization, and costs for patients with cystic fibrosis (CF) who utilized a pharmacy-based therapy management program to matched control group. We hypothesized that patient services would be associated better thus require fewer visits the emergency room or hospitalizations.This retrospective, observational cohort study used claims data from MORE2 Registry®. The sample consisted of CF patients, aged 6+, had ≥1 pharmacy...
In the US, prevalence of hepatitis C virus (HCV) has surpassed human immunodeficiency (HIV), with about 3.3 million people chronically infected disease. Given aging Baby Boomer generation and subsequent implementation age-based screening recommendations, HCV diagnoses are expected to increase. Utilization anti-viral pharmacotherapy is also increase as more effective tolerable all-oral therapies for become available in United States. This research allows payors assess disease burden treatment...
Although most patients with terminal heart failure (HF) prefer to die at home, the majority in hospitals. To determine impact of home inotropic support place death among HF, this retrospective study compared HF enrolled an infusion program a national sample HF. The rate participants (64.5%; n = 217) was significantly higher (P < .001) than age- and sex-adjusted (35.9%; 56 596). Patients participating can remain during final stage life are less likely
To measure prescribed time to therapy (TtT) and sustained virologic response (SVR). Secondary objectives were assess insurance appeals copay assistance amount facilitated by a local specialty pharmacy (LSP).This descriptive, retrospective study used joint clinical database of patients who direct-acting antivirals (DAAs) at single-center liver clinic received LSP services from December 2013 2015.Among 388 DAAs, 364 (94%) patients, 18 years age or older, initiated DAA therapy, services,...
A national specialty pharmacy implemented a split-fill option within an oral oncology patient management program to reduce costs and medication wastage resulting from early discontinuations. Payers covered dispensed medications at half-quantity intervals for each dispense up 3 months. Proactive outreach patients before they had used the initial quantity helped assess patient's tolerance new adverse effects. This study compared with similar without this taking into account discontinuation...
To compare clinical and economic outcomes of patients who received intravenous immunoglobulin (IVIG) therapies were managed by a management program vs the matched controls using administrative claim data.This retrospective cohort study used PharMetrics Plus™ database between September 1, 2011 June 30, 2014. Patients in intervention group from "high-touch" IVIG administered home infusion specialty pharmacy. A greedy propensity score matching algorithm was to identify control non-program...
Abstract Introduction Understanding longitudinal patterns of preexposure prophylaxis (PrEP) use among men who have sex with could offer insights for developing efficient and timely interventions to promote PrEP persistence. Setting We extracted 2 years pharmacy fill records 4000 males initiated in 2017 at a national chain the United States. Methods Group-based trajectory models were used develop clusters, periods defined based on optimal seroprotection probabilities (ie, frequency ≥4...
Abstract Background Specialty medications have transformed management of chronic inflammatory conditions. There is a critical need to elucidate underlying barriers and medication‐related problems (MRPs) that might contribute specialty medication non‐adherence in order minimize disease progression, treatment failure, increased healthcare utilization. Objective To characterize MRPs for patients taking conditions identify factors associated with experiencing MRPs. Methods Retrospective cohort...
Objective: To identify medication therapy issues and resolutions assess their relationship to antiretroviral (ART) adherence among participants of the Patient-Centered HIV Care Model demonstration project. Methods: Adult persons with (PWH) in United States were enrolled from August 2014 September 2016. Pharmacists conducted regular reviews documented ART non-ART suggested resolutions. Adherence was calculated using proportion days covered (PDC), mean PDC by number compared a generalized...
Abstract Background Retail health is a growing outpatient setting. Research using claims data found that antibiotics were linked with 46% of urgent care, 17% medical office, and 14% retail visits for acute respiratory infections (ARIs) which are not needed. We aimed to quantify antibiotic prescribing rates adult patients in large clinic chain electronic records identify future stewardship targets. Methods included by adults ≥18 years network clinics from 2012 2016. classified diagnoses ICD...
Abstract Background The patient-centered HIV care model was developed to integrate community pharmacists with clinical providers deliver care. project required 10 clinics share, their partnered community-based pharmacists, patients’ medical histories, laboratory results, and medications. Pharmacists reviewed the clinic data worked directly participants and/or make recommendations discuss potential intervention strategies for identified therapy-related problems. Methods We calculated...
Background: Though medication adherence is essential for graft survival, non-adherence to immunosuppressants post kidney transplant common (30–35%), potentially leading poor quality of life and increased healthcare costs. Aims: The objective this study was examine the association between survival in recipients. Methods: This retrospective, observational cohort used claims data from a single, large national pharmacy chain post-transplant follow-up OPTN Network database. sample included adult...