A5013989391- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Prostate Cancer Diagnosis and Treatment
- Tryptophan and brain disorders
- Renal and related cancers
- Gut microbiota and health
- Renal cell carcinoma treatment
- Dietary Effects on Health
- Pelvic and Acetabular Injuries
- Ferroptosis and cancer prognosis
- Prostate Cancer Treatment and Research
- Radiomics and Machine Learning in Medical Imaging
Institute of Oncology Research
2020-2021
Ente Ospedaliero Cantonale
2021
Microbes hijack prostate cancer therapy Androgens such as testosterone and dihydrotestosterone are essential for male reproduction sexual function. can also influence the growth of tumor cells, androgen deprivation (ADT) either by surgical means (castration) or pharmacological approaches (hormone suppression), is cornerstone current treatments. Pernigoni et al . found that when body was deprived androgens during ADT, gut microbiome could produce from precursors (see Perspective McCulloch...
Abstract Comprehensive genomic studies have delineated key driver mutations linked to disease progression for most cancers. However, corresponding transcriptional changes remain largely elusive because of the bias associated with cross-study analysis. Here, we overcome these hurdles and generate a comprehensive prostate cancer transcriptome atlas that describes roadmap tumor in qualitative quantitative manner. Most cancers follow uniform trajectory characterized by upregulation...
High diagnostic performance and low morbidity for renal tumor biopsy (RTB) have been described in highly experienced centers. Here we present the five-year experience of our institute performing RTB. The protocol used, safety profile accuracy obtained were analyzed.The study is a retrospective single-institution clinical data review 84 consecutive RTB small masses. Post-biopsy complications reported using Clavien-Dindo system. To measure concordance between nephrectomy specimens regarding...
Abstract Comprehensive genomic studies have delineated key driver mutations linked to disease progression for most cancers. However, corresponding transcriptional changes remain largely elusive because of the bias associated with cross-study analysis. Here, we overcome these hurdles and generate a comprehensive prostate cancer transcriptome atlas that describes roadmap tumor in an unprecedented qualitative quantitative manner. Most cancers follow uniform trajectory characterized by...
Introduction: We aimed to present the safety profile of robotic radical prostatectomy (RARP) performed in a single center medium surgical volume since its introduction and identify predictors postoperative complications.
 Methods: prospectively collected clinical data from 317 consecutive patients undergoing RARP between August 2011 November 2019 medium-volume center. Surgical procedures were by experienced surgeon. Complications according Martin criteria for reporting Clavien-Dindo...