A5001734907- 3D Printing in Biomedical Research
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Diabetes Management and Research
- Force Microscopy Techniques and Applications
- Electrospun Nanofibers in Biomedical Applications
- Cancer, Hypoxia, and Metabolism
- Tissue Engineering and Regenerative Medicine
- Medical Imaging Techniques and Applications
- Evaluation and Performance Assessment
- Innovative Microfluidic and Catalytic Techniques Innovation
- Antioxidant Activity and Oxidative Stress
- Mesenchymal stem cell research
- Blood properties and coagulation
- Fibroblast Growth Factor Research
- Metabolism, Diabetes, and Cancer
- Nicotinic Acetylcholine Receptors Study
- Viral Infectious Diseases and Gene Expression in Insects
- Systemic Lupus Erythematosus Research
- Atherosclerosis and Cardiovascular Diseases
- Social Sciences and Governance
- Neuroscience and Neuropharmacology Research
- Health Policy Implementation Science
- Photoreceptor and optogenetics research
Okinawa Institute of Science and Technology Graduate University
2019
Deutsches Diabetes-Zentrum e.V.
2015-2016
Helmholtz Zentrum München
2016
Technische Universität Dresden
2014-2016
Deutsche Forschungsgemeinschaft
2014-2016
German Center for Diabetes Research
2016
Paul Langerhans Institute Dresden
2015-2016
Heinrich Heine University Düsseldorf
2015-2016
Université de Sherbrooke
2007-2013
Health and Social Services Centre University Institute of Geriatrics of Sherbrooke
2007-2011
Emerging insulin resistance is normally compensated by increased production of pancreatic β-cells, thereby maintaining normoglycemia. However, it unclear whether this achieved adaptation β-cell function, mass, or both. Most importantly, still unknown which these adaptive mechanisms fail when type 2 diabetes develops. We performed longitudinal in vivo imaging calcium dynamics and islet mass transplanted islets Langerhans throughout diet-induced progression from normal glucose homeostasis,...
Cure of type 1 diabetes (T1D) by immune intervention at disease onset depends on the restoration insulin secretion endogenous β-cells. However, little is known about potential β-cell mass and function to recover after autoimmune attack ablation. Using a longitudinal in vivo imaging approach, we show how functional status β-cells adapt response remission T1D. We demonstrate that infiltration reduces prior and, together with emerging hyperglycemia, affects function. After intervention,...
This study presents the design and validation of a pulsatile flow perfusion bioreactor able to provide suitable environment for 3D high cell density cultures tissue engineering applications. Our system is mobile, does not require use traditional culture incubators easy sterilize. It provides real-time monitoring stable control pH, dissolved oxygen concentration, temperature, pressure, pulsation frequency, rate. In this system, cells are cultured in gel within chamber perfused by medium fed...
The non-destructive assessment and characterization of tridimensional (3D) cell tissue constructs in bioreactors represents a challenge engineering. Medical imaging modalities, which can provide information on the structure function internal organs tissues living organisms, have potential allowing repetitive monitoring these 3D cultures vitro. Positron emission tomography (PET) is most sensitive non-invasive modality, capable measuring picomolar amounts radiolabeled molecules. However, since...
Abstract This short paper reports a simple method to image low density lipoproteins (LDL) using atomic force microscopy (AFM). instrument allows imaging of biological samples in liquid and presents the advantage needing no sample preparation such as staining or fixation that may affect their general structure. Dimensions (diameter height) individual LDL particles were successfully measured. AFM revealed have quasi‐spherical structure on x y axis with an oblate spheroid z (i.e., height). LDLs...
Abstract: Using a case study methodology, this article describes the process of implementing cognitive-behavioural program in eight residential facilities Centre jeunesse du Québec. The objectives were to better understand steps required consolidate implementation and identify structural factors that facilitate impede progress successful implementation. Documentary analysis qualitative interviews allowed deconstruction into seven phases: initial reluctance, training, exploration, resistance,...
Abstract Recent developments in genetic engineering have established murine models that permit the selective control of cholinergic neurons via optical stimulation. Despite copious benefits granted by these experimental advances, sensory physiognomy organisms has remained poorly understood. Therefore, present study evaluates and neuronal response properties animal developed for optically induced acetylcholine release regulation. Auditory brainstem responses, fluorescence imaging, patch clamp...