A5075514277- Mitochondrial Function and Pathology
- Neurotransmitter Receptor Influence on Behavior
- Fluorine in Organic Chemistry
- Synthesis and Reactions of Organic Compounds
- Organic Chemistry Cycloaddition Reactions
- Radiation Therapy and Dosimetry
- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- Semiconductor materials and devices
- Effects of Radiation Exposure
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Ferroptosis and cancer prognosis
- Receptor Mechanisms and Signaling
- Copper Interconnects and Reliability
- Synthesis and Characterization of Heterocyclic Compounds
- ATP Synthase and ATPases Research
- Tryptophan and brain disorders
- Chemical Synthesis and Reactions
- Wnt/β-catenin signaling in development and cancer
- Metabolomics and Mass Spectrometry Studies
- RNA modifications and cancer
- Carbohydrate Chemistry and Synthesis
- Adenosine and Purinergic Signaling
- Cancer, Hypoxia, and Metabolism
- Chemical Synthesis and Analysis
Kagoshima University
2015-2024
Pharmac
2019-2023
Hyogo University
2019-2023
Hyogo University of Health Sciences
2018-2020
University of Health Sciences
2020
Hyogo Medical University
2019
Kumamoto University
2012
Hitachi (Japan)
2010
Meiji University
2009-2010
Renesas Electronics (Japan)
2005-2010
In cancer therapy, radioresistance or chemoresistance cells are major problems. We established clinically relevant radioresistant (CRR) that can survive over 30 days after 2 Gy/day X-ray exposures. These also show resistance to anticancer agents and hydrogen peroxide (H2O2). have previously demonstrated all the CRR examined had up-regulated miR-7-5p knockdown, they lost radioresistance. However, mechanism of losing remains be elucidated. Therefore, we investigated role in by knockdown using...
Abstract 4‐Hydroxynonenal (HNE) is an important product of plasma membrane lipid peroxidation, which a cause cell and tissue injury. Mitochondrial DNA (mtDNA)‐depleted ρ 0 cells were established using human cervical cancer oral squamous carcinoma lines. We investigated the effect reactive oxygen species in cells, especially mechanism hydrogen peroxide (H 2 O )‐mediated death. These subjected to high oxidative stress and, compared with their parental showed greater sensitivity H peroxidation....
The aim of this study was to clarify the CT features ovarian vein reflux in asymptomatic women and determine possible cause reflux.One hundred ten multiparous or uniparous 41 nulliparous were examined on MDCT. Degree, pathway, associated findings evaluated. We measured diameters left renal (LRV), veins, parauterine veins. Ratios LRV (lateral-aortomesenteric) obtained. These data then compared between with those without reflux.Reflux found 44% (48/110) parous 5% (2/41) women. Reflux flowed...
Excessive accumulation of phospholipids results in phospholipidosis (PL), which may interfere with cellular functions, leading to acute or chronic disease even death. Electron-microscopic detection cytoplasmic lamellar bodies is often used as a diagnostic criterion PL, but faster, more convenient procedure required for high-throughput assay the PL-inducing potential candidate drugs. We have developed 96-well microplate cell-culture method detecting using phosphatidylcholine-conjugated dye...
Cancer stem-like cells (CSCs) within solid tumors exhibit radioresistance, leading to recurrence and distant metastasis after radiotherapy. To experimentally study the characteristics of CSCs, radioresistant cell lines were successfully established using fractionated X-ray irradiation. The fundamental CSCs in vitro have been previously reported; however, relationship between CSC acquired radioresistance remains uncertain. efficiently this relationship, we performed both experiments...
It has been well established that dyslipidemia is a significant risk factor for coronary artery disease (CAD), however, the association between fasting triglyceride (TG) and occurrence of CAD controversial. The objective this study was to elucidate relationship TG in middle-aged Japanese men.A cohort 6,966 men (mean +/- SD: 46.6+/-5.2 years) with 10-year follow-up period conducted identify factors CAD. One hundred eleven cases were identified during follow up. Cox proportional hazard model...
Abstract The effects of long-term exposure to extreme space conditions on astronauts were investigated by analyzing hair samples from ten who had spent six months the International Space Station (ISS). Two collected before, during and after their stays in ISS; hereafter, referred as Preflight, Inflight Postflight, respectively. ratios mitochondrial (mt) nuclear (n) DNA mtRNA nRNA analyzed via quantitative PCR. combined data Postflight show a significant reduction mtDNA/nDNA Inflight,...
The regulatory factors explaining the wide spectrum of clinical phenotypes for mitochondrial 3243A>G mutation are not known. Crosstalk between nuclear genes and DNA might be one factor.In this case series, we compared 2 pairs male twins with 3243 A>G encephalomyopathy, lactic acidosis, stroke-like episodes syndrome a female control patient. One pair monozygotic presented diabetes deafness in their 30s, 40s, cardiac events death 50s. Another 20s. degree heteroplasmy various tissues organs was...