A5078017256- Synthesis and biological activity
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Biodiesel Production and Applications
- Synthesis and Biological Evaluation
- Click Chemistry and Applications
- Multicomponent Synthesis of Heterocycles
- Synthesis and Characterization of Heterocyclic Compounds
- Cancer therapeutics and mechanisms
- Enzyme Catalysis and Immobilization
- RNA and protein synthesis mechanisms
- Analytical Chemistry and Sensors
- Advanced biosensing and bioanalysis techniques
- Quinazolinone synthesis and applications
- Electrochemical sensors and biosensors
- Synthesis of Organic Compounds
- Algal biology and biofuel production
- Heat transfer and supercritical fluids
- DNA and Nucleic Acid Chemistry
- Molecular Sensors and Ion Detection
- Crystallography and molecular interactions
- Microbial Metabolic Engineering and Bioproduction
Karnatak University
2019-2024
Jain University
2024
Abstract A series of new Coumarin hydrazone oxime scaffolds were synthesised as potential anti‐TB agents. The structures the confirmed by spectroscopic and analytical techniques. X‐ray crystallography structure compound 6‐methyl‐4‐((((Z)‐((E)‐3‐(2‐phenylhydrazono)butan‐2‐ylidene)amino)oxy)methyl)‐2H‐chromen‐2‐one ( 5a ). coumarin tested in‐vitro against Mycobacterium tuberculosis H 37 Rv strain, Vero cells used to assess cytotoxicity. Compound 5b was obtained hit candidate, exhibiting MIC...
Abstract Cancer remains a complex global threat causing widespread deaths. Developing effective anticancer agents despite advancements still remained challenging. In this work it is designed and synthesised therapeutically active based on coumarin‐quinazolinone 5 ( – j ) through nucleophilic substitution reaction of 4‐bromomethyl coumarin derivatives with 6,7‐bis(2‐methoxyethoxy)quinazolin‐4(3 H )‐one characterised by using FTIR, 1 HNMR, 13 C NMR LCMS analysis. The compounds were screened...
The paper describes the construction of a new series pyrimidinone-linked thiazole derivatives through bromination initial Biginelli reaction product followed by Hantzsch synthesis route. Various analytical techniques, including FT-IR,
In the present research work, biodiesel is produced by in-situ technique using directly dried seeds of Leonotis nepetifolia. Herein, methanol plays a dual role, as solvent for extraction oil from nepetifolia and reactant in process alcoholysis presence KOH catalyst. The influence seed to molar ratio, reaction time, temperature catalyst loading investigated. result showed that maximum yield about 96% obtained with 1: 393 ratios at 60°C, 3.0% (w/w) 100 min. Biodiesel parameters are...
A series of novel acridine-thiazole bridged coumarin derivatives 3a–3i were designed, synthesized and subjected for their in-vitro antiproliferative activity on human breast cancer (MDA-MB-231), lung (A-549) colon (HT29) cell lines. In case (MDA-MB-231) line, among the nine screened compounds, 3d, 3c, 3g, 3a exhibited moderate to good with IC50 values in range 14.06–8.03 µM concentration. The compound 3d higher value 8.03 µg/mL, compared 3c 12.03 µg/mL. Whereas, compounds 3b, 3h, 3a, 3i also...
The dual app probe QnMF detect selectively antiparallel G4s through fluorescence turn-on response. It contains 19 F leading to distinct chemical shifts in response microenvironmental changes when bound G4 structures.