A5029413428- Thyroid Cancer Diagnosis and Treatment
- Alkaline Phosphatase Research Studies
- Thyroid and Parathyroid Surgery
- Infectious Diseases and Tuberculosis
- Tuberculosis Research and Epidemiology
- Drug Transport and Resistance Mechanisms
- Thyroid Disorders and Treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Diagnosis and treatment of tuberculosis
- Digestive system and related health
- Neuroendocrine Tumor Research Advances
- BRCA gene mutations in cancer
- Neonatal Health and Biochemistry
- Therapeutic Uses of Natural Elements
- Adenosine and Purinergic Signaling
- Inflammatory Bowel Disease
- Selenium in Biological Systems
- Medical and Biological Sciences
- Chemical Reactions and Isotopes
- Biosensors and Analytical Detection
- Liver Disease Diagnosis and Treatment
- Head and Neck Cancer Studies
- Enzyme function and inhibition
- Infant Nutrition and Health
- Pituitary Gland Disorders and Treatments
University Medical Center Utrecht
2023
University of Groningen
1956-2022
University Medical Center Groningen
2016-2022
The role of radiotherapy (RT) in the treatment patients with anaplastic thyroid cancer (ATC) for local tumor control is critical because mortality often secondary to complications volume rather than metastatic disease. Herein, authors report long-term outcomes RT ATC.A total 104 histologically confirmed ATC were identified who presented study institution between 1984 and 2017 received curative-intent or postoperative RT. Locoregional progression-free survival (LPFS), overall (OS), distant...
Total thyroidectomy as part of thyroid cancer treatment results in hypothyroidism requiring lifelong daily hormone replacement. Unbalanced levels result persistent complaints such fatigue, constipation, and weight increase. Therefore, we aimed to investigate a patient-derived organoid model with the potential regenerate gland. Murine human thyroid-derived cells were cultured organoids capable self-renewal which expressed proliferation putative stem cell characteristics, without change...
Patients with well-differentiated thyroid cancer, especially papillary cancer (PTC), are treated surgical resection of the gland. This is followed by post-operative radioactive iodine (I131), resulting in total ablation. Unfortunately, about 15-33% PTC patients unable to take up I131, limiting further treatment options. The aim our study was develop a organoid model potential for pre-treatment diagnosis these I131-resistant patients. tissue from thirteen used establish long-term model. These...
Background: Differentiated thyroid cancer typically has an indolent clinical course but can cause significant morbidity by local progression. Oncologic surgical resection be technically difficult due to the proximity critical normal structures in neck. Our objective was review safety, feasibility, and outcomes of definitive-intent intensity-modulated radiation therapy (IMRT) analyze whether patients receiving concurrent chemotherapy (CC-IMRT) had higher rates disease control survival over...
The role of postoperative external beam radiotherapy (EBRT) in patients with residual iodine refractory-differentiated thyroid cancer (IR-DTC) is still inconclusive. aim this retrospective study was to evaluate locoregional control (LRC) and overall survival (OS), potential side effects after EBRT for both microscopic macroscopic non-radically resected, locally advanced IR-DTC.
Thyroglobulin (Tg) is an excellent tumour marker, as detectable or increasing Tg levels are highly indicative of persistent recurrent differentiated thyroid carcinoma (DTC). The clinical value a sensitive (hs)-Tg assay in patients with DTC has not yet been established. aim this study was to investigate the additional unstimulated hs-Tg measurements (Tg-on) compared stimulated IRMA-Tg (Tg-off) follow-up DTC.We retrospectively studied treated for between 2006 and 2013 measurements. group...
We evaluated the outcomes of surgery with or without postoperative radiation therapy (PORT) in management medullary thyroid carcinoma (MTC).From two tertiary cancer centers, 297 consecutive patients MTC treated PORT (n = 46) between 1990 and 2016 alone 251) 2000 were reviewed.Ten-year cumulative incidences locoregional distant failure 30.2% 24.9% cohort, 16.9% 55.2% cohort. In T4 disease, extrathyroidal extension, N1 extranodal extension (ENE), residual disease after associated local...
Assessment of treatment outcome in current de-escalation for differentiated thyroid cancer (DTC) according to the 2015 Dutch guidelines (NL-15) and American Thyroid Association (ATA-15).Retrospectively, recommendations NL-15 ATA-15 were evaluated estimate potentially adequate, under- overtreatment DTC patients treated University Medical Center Groningen between 2007 2017.A total 240 with a cT1-T3aN0-1aM0 fulfilled inclusion criteria.After actual was given, again categorized both into low,...
Patients with Inflammatory Bowel Disease (IBD) are at increased risk of developing malignancies. IBD patients oral cavity cancer may have reduced survival compared the general population. This article describes two patients, non-smokers, on long-term use mesalazine development cancer. In clinician should be aware possible head and neck malignancies in case doubt a biopsy performed, even absence standard factors.
Paulusma, C; Groen, A; Kunne, Mok, K; Vreeling, H; Houben, Frederiks, W; van Marle, J; Bull, L; Knisely, Oude Elferink, RPJ Author Information