A5015431437- Oral Health Pathology and Treatment
- Oral and Maxillofacial Pathology
- Bee Products Chemical Analysis
- Salivary Gland Tumors Diagnosis and Treatment
- Wound Healing and Treatments
- Optical Coherence Tomography Applications
- 3D Printing in Biomedical Research
- Cancer Cells and Metastasis
- Head and Neck Cancer Studies
- Bone Tissue Engineering Materials
- Glaucoma and retinal disorders
- Tendon Structure and Treatment
- Nanoparticles: synthesis and applications
- AI in cancer detection
- Skin and Cellular Biology Research
- Cancer-related Molecular Pathways
- Musculoskeletal pain and rehabilitation
- Cancer and Skin Lesions
- Graphene and Nanomaterials Applications
- Infrared Thermography in Medicine
- Digital Imaging for Blood Diseases
- Breast Lesions and Carcinomas
- Collagen: Extraction and Characterization
- Rangeland Management and Livestock Ecology
- Wnt/β-catenin signaling in development and cancer
Vellore Institute of Technology University
2015-2025
UNSW Sydney
2018-2023
Creative Commons
2021
ICFAI Foundation for Higher Education
2019
Indian Institute of Technology Kharagpur
2010-2014
Aravind Eye Hospital
2014
Background The assessment of malignant potential oral submucous fibrosis grades vis-à-vis their progression towards malignancy is associated with expression possible multiple molecular markers. Aims To analyse p63, E-cadherin and CD105 in this premalignant pathosis a view to unravel understand the these molecules as Methods mucosal biopsies (normal, without dysplasia) were studied routine H&E, by immunohistochemistry for expression. p63 was assessed percentage positive nuclei. estimated...
Antibacterial activity of nanoparticles (NPs) and nanocomposites (NCs) has received wide spread attention in biomedical applications. In this direction, the authors prepared zinc oxide (ZnO), iron (Fe3O4), their composite including reduced graphene (rGO) by hydrothermal method. The structural microstructural properties synthesised NPs NCs were investigated XRD, FT-IR, UV-Vis, TGA, TEM analysis. PEG-coated ZnO Fe3O4 form hexagonal wurtzite inverse spinel structures, respectively. forms...
Evaluation of molecular pathology markers using a computer-aided quantitative assessment framework would help to assess the altered states cellular proliferation, hypoxia, and neoangiogenesis in oral submucous fibrosis could improve diagnostic interpretation gauging its malignant potentiality.Immunohistochemical (IHC) expression c-Myc, hypoxia-inducible factor-1-alpha (HIF-1α), vascular endothelial growth factor (VEGF), VEGFRII, CD105 were evaluated 58 biopsies quantification. After digital...
Multiple emulsions are thermodynamically stable systems that mark applications in various fields including drug delivery systems. They allow enhanced availability of drugs, greater absorption, and present reduced toxicity, among other desirable properties. In this work, we aimed to formulate a unique double emulsion (O1/W + W1/O2/W/W) with three bioactive components viz. Ocimum tenuiflorum oil, Cocos nucifera oil crystalline Cinnamomum camphora. Three surfactants different HLB values...
Background: Oral submucous fibrosis (OSF) is a pre-cancerous condition with features of chronic, inflammatory and progressive sub-epithelial fibrotic disorder the buccal mucosa. In this study, malignant potentiality OSF has been assessed by quantification immunohistochemical expression epithelial prime regulator-p63 molecule in correlation to its (oral squamous cell carcinoma [OSCC] normal counterpart [normal oral mucosa [NOM]). Attributes spatial extent distribution p63+ epithelium have...
Abstract Prostaglandin analogues (PG), beta‐blockers (BB) or their combination (PG+BB) are used primarily to reduce the intraocular pressure (IOP) pathologically associated with glaucoma. Since, fibrosis of trabecular meshwork (TM) is a major aetiological factor in glaucoma, we studied effect these drugs on fibrosis‐associated gene expression TM primary glaucoma patients. In present study, and iris open‐angle (n = 32) angle‐closure 37) patients were obtained surgically during trabeculectomy...
Direct noninvasive visualization of wound bed with depth information is important to understand the tissue repair. We correlate skin swept-source-optical coherence tomography (OCT) histopathological and immunohistochemical evaluation on traumatic lower limb wounds under honey dressing compare assess repair features acquired noninvasively invasively. Analysis optical biopsy identifies an uppermost brighter band for stratum corneum region specific thickness (p < 0.0001) gray-level intensity...
Oral squamous cell carcinoma (OSCC) is a highly invasive and pervasive human oral neoplasia, accounting for approximately 90% of all cavity carcinomas worldwide. Despite technological advancements, tumor spread consequent relapse result in meagre 5- year survival rates less than 60%. Metastasis the culmination multiphase transition, characterized as epithelial-to-mesenchymal transition (EMT), which stipulates gradual acquisition migratory phenotype epithelial cells. Physiologically, EMT...
Honey is recognized traditionally for its medicinal properties and also appreciated as a topical healing agent infected noninfected wounds. This study evaluates impact of honey-based occlusive dressing on nonhealing (nonresponding to conventional antibiotics) traumatic lower limb wounds (n = 34) through clinicopathological immunohistochemical (e.g., expression p63, E-cadherin, Collagen I III) evaluations enrich the scientific validation. Clinical findings noted nonadherence honey with...
Precise histopathological localization of E-cadherin and p63 is immense importance in understanding the integrity oral mucosal stratified epithelium normal diseased conditions. Necessarily immunohistochemical imaging should have minimum bleaching impact on dyes ability to produce clear crisp images. Here ApoTome provides an alternative with metal halide light source structured illumination under assistance grids, along integrated image processing modality generate images digital interface....
Objective. When exploring the scientific basis of reflexology techniques, elucidation surface and subsurface features areas (RAs) is crucial. In this study, subcutaneous RAs related to lumbar vertebrae were evaluated by swept source-optical coherence tomography (SS-OCT) in subjects with without low back pain (LBP). Methods. Volunteers LBP (n = 6 (male : female 1 1)) 15 2 3)) clinically examined terms skin colour (visual perception), localised tenderness analogue scale) structural as well...
Objective Problems in pre-cancer diagnosis complicate cancer theragnosis as well life expectancy. There is uncertainty regarding malignant transformation of oral submucous fibrosis (OSF), an with dysplastic (OSFWD) and non-dysplastic (OSFWT) subtypes. Understanding the structural, molecular physical aspects epithelial homeostasis may be useful. Materials methods Histopathological grading biopsy sections was performed using H&E staining. Alterations surface architecture different groups...
Late-diagnosis of malignant potentiality oral pre-cancers like Oral Sub-mucous Fibrosis (OSF) contributes towards high mortality cancer patients. Current study intends to differentiate Normal Mucosa (NOM) from OSF stages in terms expression a prime candidate gene (p63), correlated with epithelial proliferation and maturation, for better assessment the pre-cancer. Fifty three biopsies (i.e. 8 NOM, 45 patients without dysplasia) were histopathologically evaluated by hematoxylin eosin, whereas,...
Précis: Anterior chamber depth, IOP, and thickness confounded the assessment of corneal biomechanical properties with noncontact applanation in glaucoma eyes. Compared normal eyes, which underwent long-term treatment or filtration surgery, had similar properties. Purpose: The purpose this study was to evaluate stiffness primary angle-closure (PACG) open-angle (POAG) eyes that were subgrouped on basis type topical medication surgery using applanation. Methods: All retrospectively reviewed for...