A5030891624- Pancreatic function and diabetes
- Adipose Tissue and Metabolism
- Wnt/β-catenin signaling in development and cancer
- Cancer-related gene regulation
- Diet, Metabolism, and Disease
- Metabolism, Diabetes, and Cancer
- PI3K/AKT/mTOR signaling in cancer
- Melanoma and MAPK Pathways
- Galectins and Cancer Biology
- Genetics, Aging, and Longevity in Model Organisms
- Lipid metabolism and biosynthesis
- Lymphoma Diagnosis and Treatment
Heidelberg University
2024
University Hospital Heidelberg
2024
German Cancer Research Center
2024
University of Würzburg
2020-2022
Obesity-induced diabetes affects >400 million people worldwide. Uncontrolled lipolysis (free fatty acid release from adipocytes) can contribute to and obesity. To identify future therapeutic avenues targeting this pathway, we performed a high-throughput screen identified the extracellular-regulated kinase 3 (ERK3) as hit. We demonstrated that β-adrenergic stimulation stabilizes ERK3, leading formation of complex with cofactor MAP kinase-activated protein 5 (MK5), thereby driving...
Epstein-Barr virus (EBV) is best known for infection of B cells, in which it usually establishes an asymptomatic lifelong infection, but also associated with the development multiple cell lymphomas. EBV infects epithelial cells and all cases undifferentiated nasopharyngeal carcinoma (NPC). etiologically linked at least 8% gastric cancer (EBVaGC) that comprises a genetically epigenetically distinct subset GC. Although we have very good understanding entry lymphomagenesis, sequence events...
Article5 May 2021Open Access Source DataTransparent process Protein Kinase D2 drives chylomicron-mediated lipid transport in the intestine and promotes obesity Jonathan Trujillo-Viera orcid.org/0000-0003-0566-4589 Rudolf-Virchow-Zentrum, Center for Integrative Translational Bioimaging, University of Würzburg, Germany These authors contributed equally to this work. Search more papers by author Rabih El-Merahbi orcid.org/0000-0001-8133-8297 Vanessa Schmidt Till Karwen Angel Loza-Valdes...
ABSTRACT Maintenance of homeostatic processes ensure curtailment intestinal tumorigenesis. Inactivating mutations to Adenomatous Polyposis Coli ( Apc ) result in aberrantly activated Wnt signalling and initiates colorectal cancer (CRC) approx. 80% cases, yet our understanding the subcellular mechanisms that modulate dysregulated pathway activity is limited. Here, using a conditional vivo genetic screen, we identify Rab35 GTPase as novel tumour suppressor modulates regional after loss...
Kinases represent one of the largest druggable families proteins. Importantly, many kinases are aberrantly activated/de-activated in multiple organs during obesity, which contributes to development diabetes and associated diseases. Previous results indicate that complex between Extracellular-regulated kinase 3 (ERK3) Mitogen-Activated Protein Kinase (MAPK)-activated protein 5 (MK5) suppresses energy dissipation promotes fatty acids (FAs) output adipose tissue and, therefore obesity diabetes....