A5058696247- Nitric Oxide and Endothelin Effects
- Estrogen and related hormone effects
- Cancer survivorship and care
- Receptor Mechanisms and Signaling
- Proteoglycans and glycosaminoglycans research
- Health and Medical Studies
- Nutrition, Genetics, and Disease
- Mechanisms of cancer metastasis
- Protein Tyrosine Phosphatases
- Biomedical and Chemical Research
- Acne and Rosacea Treatments and Effects
- Cancer, Hypoxia, and Metabolism
- Cancer Risks and Factors
- Glycosylation and Glycoproteins Research
- Diet and metabolism studies
- Cell Adhesion Molecules Research
- Polyamine Metabolism and Applications
- Nutrition and Health in Aging
- Fibroblast Growth Factor Research
- Protease and Inhibitor Mechanisms
- Vitamin C and Antioxidants Research
- Pharmacological Effects of Natural Compounds
- Galectins and Cancer Biology
- Pharmacology and Obesity Treatment
- Medical and Health Sciences Research
University Hospital Schleswig-Holstein
2019-2024
University of Lübeck
2019-2024
Universitätsklinik für Diabetologie, Endokrinologie, Ernährungsmedizin & Metabolismus
2019
Orthopädische Praxis
2018
University Hospital Münster
2005-2017
University of Münster
2007-2017
Praxis
2017
LVR-Klinik Köln
2017
Botanic Garden and Botanical Museum Berlin
2017
B. Braun (Netherlands)
2017
The heparan sulfate proteoglycan syndecan-1 (Sdc1) modulates cell proliferation, adhesion, migration and angiogenesis. Proteinase-mediated shedding converts Sdc1 from a membrane-bound coreceptor into soluble effector capable of binding the same ligands. In breast carcinomas, overexpression correlates with poor prognosis an aggressive phenotype. To distinguish between roles shed forms in cancer progression, human MCF-7 cells were stably transfected plasmids overexpressing wild-type (WT),...
(1) Background: Spermidine is a biogenic polyamine that plays crucial role in mammalian metabolism. As spermidine levels decline with age, supplementation suggested to prevent or delay age-related diseases. However, valid pharmacokinetic data regarding remains lacking. Therefore, for the first time, present study investigated pharmacokinetics of oral supplementation. (2) Methods: This was designed as randomized, placebo-controlled, triple-blinded, two-armed crossover trial two 5-day...
The negative impact of unmanaged psychological distress on quality life and outcome in breast cancer survivors has been demonstrated. Fortunately, studies indicate that can effectively be addressed even prevented using evidence-based interventions. In Germany prescription-based mobile health apps, known as DiGAs (digital applications), are fully reimbursed by insurances, were introduced 2020. this study, the effectiveness an approved DiGA was investigated: personalized coaching app PINK!...
Introduction: Overweight and a lack of physical activity not only increase the risk recurrence in breast cancer patients but also negatively impact overall long-term survival, as well quality life. The results presented here are first real-world data from DiGA PINK! Coach examining BMI app users. Based on literature, an approximate weight gain 10% over 6 months decrease can be expected. purpose this study is to retrospectively investigate effects setting patients’ level during acute...
Introduction: This pilot study aimed to investigate the effects of using an app-based certified medical product named PINK! on breast cancer patients and survivors. The objectives were measure psychological distress, physical activity, therapy-related fatigue identify trends develop a design for subsequent multicentric proof efficacy RCT. Materials Methods: offers individualized, evidence-based therapy side-effect management, mindfulness-based stress reduction, nutritional education,...
Choline is an essential nutrient that involved in various developmental processes during pregnancy. While the general adequate choline intake (AI) for adults has been set at 400 mg/day by European Food Safety Authority (EFSA), AI of 480 derived pregnant women. To date, women Germany not investigated yet. Therefore, this survey, total from dietary and supplementary sources was estimated using online questionnaire. A 516 participated which 283 met inclusion criteria (13 to 41 weeks gestational...
Impaired glucose homeostasis is a significant risk factor for cardiometabolic diseases, whereas the efficacy of available standard therapies limited, mainly because poor adherence. This post-marketing study assessed glucose-lowering potential synbiotic-based formulation.
Background The emergence and spread of multidrug resistant microorganisms is a serious threat to transnational public health. Therefore, it vital that cross-border outbreak response systems are constantly prepared for fast, rigorous, efficient response. This research aims improve collaboration by identifying, visualizing, exploring two networks likely unfold during outbreaks involving the Netherlands Germany. Methods Quantitative methods were used explore carbapenem Enterobacteriaceae in...
Purpose The dietary practices (DPs) of university students are influenced by many external factors. Therefore, we investigate how the DPs in Germany changed during SARS-CoV-2 pandemic, what main motivations were for those changes, and effect closure catering had on students. Methods A total 560 from two universities Lübeck (Germany) surveyed online a pilot phase. final questionnaire was subsequently administered at 10 other German (399 respondents). sociodemographic factors, habits, food...
Purpose: The aim of this study is to retrospectively investigate the impact DiGA Pink! Coach in a real-world setting on breast cancer patients without manifest psychological distress, objectified by means Patient Health Questionnaire-9 (PHQ-9 0-4) at baseline 12 weeks.
Fatigue and psychological stress during after breast cancer therapy are among the most common side effects. They mutually influence each other. Digital interventions such as Pink! Coach DiGA can help in treating or preventing them.