A5032770424- Steroid Chemistry and Biochemistry
- Cell death mechanisms and regulation
- Ubiquitin and proteasome pathways
- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
- Estrogen and related hormone effects
- Hormonal Regulation and Hypertension
- Microbial Metabolic Engineering and Bioproduction
- Cancer-related Molecular Pathways
- Metabolism, Diabetes, and Cancer
- RNA and protein synthesis mechanisms
- Growth Hormone and Insulin-like Growth Factors
- PI3K/AKT/mTOR signaling in cancer
- Bacterial Genetics and Biotechnology
- Enzyme Production and Characterization
- Vitamin C and Antioxidants Research
- Epigenetics and DNA Methylation
- Cancer therapeutics and mechanisms
- Inflammatory Bowel Disease
- RNA modifications and cancer
- Kruppel-like factors research
- Gut microbiota and health
- Traditional Chinese Medicine Analysis
- Genomics and Chromatin Dynamics
- Vitamin D Research Studies
Sookmyung Women's University
2013-2024
Samsung (South Korea)
2010
Jeonbuk National University
2009
Klotho was originally characterized as an anti-aging gene that predisposed Klotho-deficient mice to a premature aging-like syndrome. Recently, KLOTHO reported function secreted Wnt antagonist and tumor suppressor. Epigenetic silencing of antagonists is considered common event in wide range human malignancies. Abnormal activation the canonical pathway due epigenetic deregulation thought play crucial role cervical tumorigenesis. In this study, we examined carcinoma.Loss mRNA observed several...
Oral route colon-targeted drug delivery systems (CDDSs) are desirable for the treatment of ulcerative colitis (UC). However, CDDSs challenging owing to physiological and anatomical barriers associated with gastrointestinal tract (GIT). In this study, we developed an effective enzyme-triggered controlled release system using curcumin–cyclodextrin (CD–Cur) inclusion complex as core low molecular weight chitosan unsaturated alginate resulting nanoparticles (CANPs) shell. The formed CD–Cur–CANPs...
A 34-KD protein encoded by the SEI-1 gene (p34(SEI‑1)), is a relatively recently discovered oncoprotein that has multiple important biological functions. Our data show p34(SEI-1) enhances cancer cell survival and promotes tumorigenesis downregulating tumor suppressor PTEN, negative regulator of PI3K/AKT signaling pathway, therefore activating pathway. In this process, positively affects NEDD4-1 expression both at transcriptional levels. Furthermore, levels were found to be coordinated in...
Bacterial biofilm causes severe antibiotic resistance. An extracellular polymeric substance (EPS) is the main component in bacterial biofilm. Alginate a key EPS of Pseudomonas aeruginosa and responsible for surface adhesion stabilization lyase has emerged as an efficient therapeutic strategy targeting to degrade alginate P. aeruginosa. However, application this enzyme limited by its poor stability. In study, chitosan nanoparticles (CS-NPs) were synthesized using low molecular weight Aly08...
Lung cancer is a type of deadly and leading cause associated death worldwide. BCL-2 protein considered as an imperative target for the treatment due to their significant involvement in cell survival death. A carbazole-piperazine hybrid molecule ECPU-0001 was designed synthesized potent targeting agent with effective anticancer activity. Interaction ECPU-001 has been assessed by docking, molecular dynamics (MD) simulation, thermal shift assay. Further, vitro vivo activity executed...
Ulcerative colitis (UC) is a complex chronic inflammatory disease closely associated with gut homeostasis dysfunction. The previous studies have shown that stachyose, functional food additive, has the potential to enhance health and alleviate UC symptoms. However, underlying mechanism of its effects remains unknown. In this study, our findings showed dietary supplements stachyose had significant dose-dependent protective effect on symptoms, regulation microbiota, restoration Treg/Th17 cell...
β-Galacto-oligosaccharide (β-GOS) showed great potential in ulcerative colitis (UC) adjuvant therapy. Herein, the preventive and prebiotic effect of enzymatic-synthesized α-linked galacto-oligosaccharide (α-GOS) was investigated dextran sodium sulfate-induced gut microbiota dysbiosis mice. Compared with β-GOS, α-GOS supplement more effective improving efficacy, promoting colonic epithelial barrier integrity, alleviating inflammation cytokines. Moreover, activation NOD-like receptor (NLR)...
// Samil Jung 1, * , Chengping Li Jingjing Duan 1 Soonduck Lee Kyeri Kim Yeonji Park Young Yang Keun-Il Jong-Seok Lim Chung-Il Cheon Young-Sook Kang 2 Myeong-Sok Department of Life Systems, Sookmyung Women's University, Seoul, 140-742, South Korea College Pharmacy, These authors have contributed equally to this work Correspondence to: Lee, e-mail: mslee@sookmyung.ac.kr Keywords: TRIP-Br1, autophagy, apoptosis, necroptosis, nutrient/serum starvation Abbreviations: Transcriptional regulator...
// Chengping Li 1, * , Samil Jung Soonduck Lee 1 Dongjun Jeong 2 Young Yang Keun-Il Kim Jong-Seok Lim Chung-Il Cheon Changjin Young-Sook Kang 3 Myeong-Sok Department of Life Systems, Sookmyung Women's University, Seoul, 140–742, South Korea Pathology, College Medicine, Soonchunhyang Chonan, 330–090, Pharmacy, These authors have contributed equally to this work Correspondence to: Lee, e-mail: mslee@sookmyung.ac.kr Keywords: Nutrient/serum starvation, apoptosis, TRIP-Br3, TRIP-Br1, XIAP...
Oligoalginate lyases catalyze the degradation of alginate polymers and oligomers into monomers, a prerequisite for biotechnological utilizing alginate. In this study, we report cloning, expression biochemical characterization new polysaccharide lyase (PL) family 17 oligoalginate lyase, OalV17, from marine bacterium Vibrio sp. SY01. The recombinant OalV17 showed metal ion independent detergent resistant properties. Furthermore, is an exo-type enzyme that yields monomers as main product...
Corynebacterium glutamicum , a gram-positive bacterium, has been widely used for industrial amino acid production. his genes are located and transcribed in two unlinked loci, hisEG hisDCB–orf1–orf2–hisHA–impA–hisFI. The latter operon starts the transcription at C residue localized 196 bp upstream of hisD ATG start codon. Our computer-based sequence analysis showed that region corresponding to untranslated 5′ end transcript, named leader region, displays typical features T-box transcriptional...
Paulownia coreana has traditionally been used as the medicine and health food in treatment of cancer infectious diseases. In present study, a new antiproliferation agent, isoatriplicolide tiglate (PCAC) was isolated from chloroform soluble fraction leaves coreana. The activities PCAC plant extract examined breast cervical cell lines time-and dose-dependent manners. Our vitro experiments showed that suppresses growth proliferation cells at relatively low concentration ( < 10 µg/mL) induces...
Breast cancer is one of the most common types in women and highly treatable by radiotherapy. However, repeated exposure to radiation results tumor cell resistance. Understanding molecular mechanisms involved response tumors γ-irradiation important for improving For this reason, we aimed identify radiation-responsive genes at protein level. In present study, observed differentially expressed proteins using 2D-PAGE MALDI-TOF-MS global analysis expression patterns ionizing (IR). When were...
The p34SEI-1 oncoprotein is involved in a transcriptional regulation, cell cycle apoptosis, development and many other important cellular functions. Our present study suggests that can promote metastasis by enhancing migration invasion of cancer cells. Consistently, expression was found to be increased as the tumor invasiveness progressed human breast tissues. may activating PI3K/AKT signaling pathway. In this process, activates two different serine/threonine kinases, AKT or ILK, depending...
Vitamin C is considered as an important anticancer therapeutic agent although this view debatable. In study, we introduce a physiological mechanism demonstrating how vitamin exerts activity that induces cell cycle arrest and apoptosis. Our previous current data reveal p53 tumor suppressor the prerequisite factor for stronger effects of C. addition, C-mediated cancer cytotoxicity appears to be achieved at least partly through downregulation p34SEI-1 oncoprotein. study showed increases...
// Samil Jung 1, * , Hyung-In Moon 2, Beom Suk Lee Subeen Kim 1 Nguyen Thi Ngoc Quynh Jimin Yu 2 Dan-Diem Le Zolzaya Sandag Hyegyeong Hyojeong Hai Anh Young Yang Jong-Seok Lim Keun-Il and Myeong-Sok Department of Biological Science, Sookmyung Women's University, Seoul, 14310, South Korea Medicinal Biotechnology, College Health Sciences, Dong-A Busan, 49315, These authors have contributed equally to this work Correspondence to: Lee, email: mslee@sookmyung.ac.kr Keywords: Angelica amurensis;...