Objectives: Diabetic nephropathy (DN) is a major complication of diabetes that requireseffective treatment options. This study explores the potential benefits saffron extractas remedy derived from medicinal plants, focusing on its effects key inflammatorygenes—Toll-like receptor 4 (TLR-4), S100 calcium-binding protein A8 (S100A8), andHigh Mobility Group Box 1 (HMGB1)—as well as role in reducing oxidative stressin kidney tissue rats with type diabetes. Methods: The were randomly divided into...

Aim: This study evaluate the antifungal effects of duloxetine as monotherapy and in combination with fluconazole on fluconazole-resistant C. albicans. Methods: In this vitro study, a suspension albicans clinical isolates from oral candidiasis was prepared using CLSI M37-A3 method. Fluconazole (3 mg/mL) (160 µg/mL) stock solutions were serially diluted 9 times (0.625-160 µg/mL for 0.5-128 fluconazole). Their activity against evaluated by microdilution method through broth media. The minimum...

The oxidative modification of low density lipoprotein (LDL) is closely associated with an increased risk for coronary artery disease (CAD) in diabetic patients. purpose this study to investigate the relation between serum vitamin E and selenium, paraoxonase-1 (PON1) activity, total antioxidant capacity (TAC), oxidant status (TOS), malondialdehyde (MDA), stress index (OSI) values susceptibility LDL possibility CAD patients.This was designed as a case control survey 82 diabetes patients...

The aim of the present study was to investigate effect silymarin (Livergol) on liver enzymes in patients taking isotretinoin (Roaccutane). In this double-blind clinical trial, 74 with acne and were randomly assigned into intervention (N = 37) control groups. group received a 140 mg Livergol capsule per day for 30 days. starch-containing as placebo once Liver enzyme levels measured before after intervention. data analyzed using chi-square test, Independent t paired sample test analysis...

Abstract Objectives Multiple sclerosis (MS) is a progressive and often debilitating neurological disorder. This chronic disease has high prevalence in the world also Iran. Fatigue common symptom of disease, which causes serious mental psychological discomfort. Simple saffron syrup, contains some compounds that can be effective relieving symptom. The object this study to investigate effect simple syrup on fatigue patients with MS. Methods pre-post evaluates rate MS (30 participants) according...

Most individuals who suffer from spinal cord injury (SCI) experience neuropathic pain, which currently has no effective treatment. In this study, we examined how testosterone affects pain resulting SCI.

Background: Multidrug-resistant (MDR) Acinetobacter baumannii is one of the most common nosocomial pathogens. Antimicrobial peptides (AMPs) have been introduced as a viable alternative to antibiotics in treatment MDR Objectives: This study was designed assess vitro pharmacokinetics combination two potent AMPs, LL-37 and oncorhyncin II, against A. (ATCC19606). Methods: The synthesized genes II were into Escherichia coli BL21 expression host. minimum inhibitory concentration (MIC), time-kills,...

Background: High levels of heavy metals in food are general concerns including carcinogenic effects. According to studies, the accumulation crops and consumption these products diet, has led serious health concerns. This study investigated concentrations lead cadmium popular agricultural products. Methods: In this descriptive study, some fresh (leafy vegetables, tubers, cucurbits seeds) were collected winter summer. The samples transferred laboratory stored a cold room. After preparation...

Background: The treatment of Staphylococcus aureus infections has become a public health crisis due to the extensive development antimicrobial resistance. Antimicrobial peptides (AMPs) have been introduced as promising naturally-derived alternatives antibiotics. LL-37 and oncorhyncin II are 2 AMPs with notable proven antibacterial effects. Objectives: This study aimed produce recombinant investigate their synergistic effects on S. (ATCC25923). Methods: synthetic genes were individually...

Abstract Objectives Liver cirrhosis is one of the most important causes death from liver diseases. Nowadays, use herbal medicines has increased due to its availability, less side effects and cheapness for treatment The present study was conducted examine therapeutic hydroalcoholic extract Scrophularia striata ( S. ) on thioacetamide-induced in rats through evaluate oxidative stress markers expression metalloproteinase 1 (TIMP 1), toll-like receptor-4 (TLR-4), Mitofusin (MFN2) genes. Methods...

Investigation of the effect Ginkgo biloba leaf extract on spatial memory impairment and hippocampal neuronal loss caused by diabetes induced streptozotocin in rats

Abstract Objectives The present study was conducted to examine antidiabetic effects of Artemisia absinthium ethanolic extract [ A. ] and investigate its on oxidative stress markers the expression TLR4, S100A4, Bax Bcl-2 genes in kidney STZ-induced diabetic rats. Methods Thirty six rats (weight 200–250 g) were randomly divided into diabetes control groups. Induction performed using STZ (55 mg/kg.bw). Biochemical parameters (SOD MDA) measured spectrophotometry after 60 days treatment. analyzed...

Type 1 diabetes is one of the most important causes microvascular complications such as nephropathy. On other hand, use herbal medicines more affordable and has fewer side effects. Therefore, this study was conducted to assessment therapeutic effect saffron in diabetic nephropathy by regulating expression CTGF RAGE genes well oxidative stress rats with type diabetes.In study, we used 24 Wistar four groups. To induce diabetes, a 55 mg/kg.bw dose streptozotocin intraperitoneally. were...

B Background : GI decontamination is required frequently in management of intoxicated patients. Activated charcoal used for this purpose normally. Is it possible that powdered industrial as a substitute? Present study was conducted to determine efficiency prevention absorption diazepam, compared activated charcoal. Method: 30 Sprague–dawley rats were randomly divided into 3 equal groups. 20 mg/kg diazepam given orally all No performed the control group. and (1 g/kg dissolved 10 ml water)...

Background: Nitrate content is one of the most critical factors to determine quality vegetables, and its permissible limits in food chain important human health. Due harmful effects nitrate, many studies have been conducted on accumulation crops recent years. This study assessed nitrate concentrations some edible vegetables associated health risks. Methods: In this descriptive study, raw agricultural produce, such as leafy tubers, cucurbits, kitchen produce grains were collected winter...

Objective(s) While the nucleus accumbens and striatum have received much attention regarding their roles in stereotyped behaviors, role of medial prefrontal cortex (mPFC) has not been investigated to same degree. Few studies reported mPFC dopaminergic induction locomotor hyperactivity. The is a heterogeneous area (the anterior cingulated, prelimbic, infralimbic) with particular inputs outputs subcortical regions that may different effects on behaviors. In this work, apomorphine, non-specific...

Pain associated with various underlying pathologies is a major cause of morbidity and diminished life quality in diabetic patients. Effective control pain requires the use analgesics best efficacy minimal side effects. Therefore, our aim this study was to investigate effects non-steroidal anti-inflammatory drugs (NSAIDs) on rats. In study, we investigated analgesic belonging three different classes NSAIDs rat model diabetes. Four groups received normal saline, diclofenac, piroxicam...

The behavioral and molecular effects of estradiol progesterone on a rat model spinothalamic tract lesion