A5078375515- Nanoplatforms for cancer theranostics
- Cancer Immunotherapy and Biomarkers
- Effects of Radiation Exposure
- Dietary Effects on Health
- Advanced Nanomaterials in Catalysis
- Bone Tissue Engineering Materials
- Hydrogen's biological and therapeutic effects
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Cells and Metastasis
- Ultrasound and Hyperthermia Applications
- Bone health and osteoporosis research
- Glioma Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Graphene and Nanomaterials Applications
- Cancer Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Fibroblast Growth Factor Research
- Cancer, Hypoxia, and Metabolism
- Hemoglobin structure and function
- Nanoparticle-Based Drug Delivery
- Radiation Therapy and Dosimetry
- Orthopaedic implants and arthroplasty
National Yang Ming Chiao Tung University
2020-2025
The University of Texas MD Anderson Cancer Center
2018
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most difficult cancers to treat. It is refractory existing therapies, including immunotherapies, due presence an excessive desmoplastic stroma, which restricts penetration drugs and cytotoxic CD8+ T cells. Stromal modulation has shown promising results in enhancement immune checkpoint blockade treatment PDAC. We demonstrate here effective stromal by a polymeric micelle-based nanoformulation codeliver sonic hedgehog inhibitor...
A hybrid nano-complex, Eu:SPIO@BSA, is designed to prevent lung metastasis in osteosarcoma and enhance the accumulation of Eu tumors.
Purpose: Glioblastoma is a highly aggressive brain tumor with universally poor outcomes. Recent progress in immune checkpoint inhibitors has led to increased interest their application glioblastoma. Nonetheless, the unique milieu posed remarkable challenges efficacy of immunotherapy. We aimed leverage radiation-induced immunogenic cell death overcome immunosuppressive network Methods: developed novel approach using gold-core silica-shell nanoparticles (Au@SiO 2 NPs) combination low-dose...
Osteoporosis, characterized by reduced bone mass and structural deterioration, poses a significant healthcare challenge. Traditional treatments, while effective in reducing fracture risks, are often limited side effects. This study introduces novel nanocomplex, europium (Eu) ions-doped superparamagnetic iron oxide (SPIO) nanocrystals encapsulated poly(lactic-co-glycolic acid) (PLGA) nanospheres, abbreviated as SPIO:Eu@PLGA potential therapeutic agent for osteoporosis modulating macrophage...
Radiation dermatitis (RD) is a common side effect in patients receiving radiotherapy. Currently, clinical skincare approaches for acute RD vary widely among institutions and lack consensus. Hydrogen molecules, acting as radioprotective agents by selectively scavenging free radicals, have the potential to protect against RD. In this study, we demonstrate that hydrogen reduces double-strand breaks, mitochondrial depolarization, inflammatory cytokines induced irradiation damage HaCaT cells....
Hypoxia, a phenomenon that occurs when the oxygen level in tissues is lower than average, commonly observed human solid tumors. For oncological treatment, hypoxic environment often results radioresistance and chemoresistance. In this study, new multifunctional carrier, carboxymethyl hexanoyl chitosan (CHC) nanodroplets decorated with perfluorohexane (PFH) superparamagnetic iron oxide (SPIO) (SPIO@PFH-CHC), was developed investigated. PFH-based carriers can augment oxygenation within tumor...
Osteosarcoma is insensitive to radiation. High-dose radiation often used as a treatment but causes side effects in patients. Hence, it important develop tumor cell-- targeted radiotherapy that could improve efficiency on cells and reduce the toxic effect normal during treatment. In this study, we developed an innovative method for treating osteosarcoma by using novel radiation-enhancer (i.e., carboxymethyl-hexanoyl chitosan-coated self-assembled Au@Fe3O4 nanoparticles; CSAF NPs). NPs were...