A5102756046- Cellular transport and secretion
- Lipid Membrane Structure and Behavior
- Advanced Fluorescence Microscopy Techniques
- Photoreceptor and optogenetics research
- Cytokine Signaling Pathways and Interactions
- ATP Synthase and ATPases Research
- Advanced biosensing and bioanalysis techniques
- Pancreatic function and diabetes
- Endoplasmic Reticulum Stress and Disease
- Retinal Development and Disorders
- Protein Tyrosine Phosphatases
- Blood disorders and treatments
- Immunodeficiency and Autoimmune Disorders
- Galectins and Cancer Biology
- Extracellular vesicles in disease
- Photosynthetic Processes and Mechanisms
Max Planck Institute for Biophysical Chemistry
2003-2017
Max Planck Society
2005-2008
Presynaptic active zones (AZs) are unique subcellular structures at neuronal synapses, which contain a network of specific proteins that control synaptic vesicle (SV) tethering, priming, and fusion. Munc13s core AZ with an essential function in SV priming. In hippocampal neurons, two different Munc13s-Munc13-1 bMunc13-2-mediate opposite forms presynaptic short-term plasticity thus differentially affect characteristics. We found most presynapses cortical neurons only Munc13-1, whereas ∼10%...
The adrenoleukodystrophy protein (ALDP) and the 70-kDa peroxisomal membrane (PMP70) are half-ATP-binding cassette (ABC) transporters in mammalian peroxisome membrane. Mutations gene encoding ALDP result a devastating neurodegenerative disorder, X-linked (X-ALD) that is associated with elevated levels of very long chain fatty acids because impaired beta-oxidation. interactions ABC transporters, their role membrane, functions disease pathogenesis poorly understood. Studies on revealed...
Adopted for the live cell, methods of fluorescence resonance energy transfer (FRET) together with GFP-technology have taken us beyond limits optical resolution and allow to resolve proteinÐprotein interactions in 3-7 nm proximity real time a cell. To reliably study cellular proteins involved trafficking cholera toxin we first analysed maturation each chimeric protein. Cytosolic partners responsible transport were fused cyan fluorescent protein (CFP) co-expressed yellow (YFP)-fused...