A5042392875- Radical Photochemical Reactions
- Sulfur-Based Synthesis Techniques
- Oxidative Organic Chemistry Reactions
- Chemical Synthesis and Reactions
- Gastrointestinal Tumor Research and Treatment
- Cancer therapeutics and mechanisms
- Sarcoma Diagnosis and Treatment
- Lignin and Wood Chemistry
- Acute Lymphoblastic Leukemia research
- Photodynamic Therapy Research Studies
- Metastasis and carcinoma case studies
- Enzyme-mediated dye degradation
- Dyeing and Modifying Textile Fibers
- Cancer, Lipids, and Metabolism
- Phytochemicals and Antioxidant Activities
- Advanced Breast Cancer Therapies
- Neurofibromatosis and Schwannoma Cases
- Metabolism, Diabetes, and Cancer
- Photochromic and Fluorescence Chemistry
- Cancer, Hypoxia, and Metabolism
- DNA and Nucleic Acid Chemistry
- Gastrointestinal disorders and treatments
- Bioactive Compounds and Antitumor Agents
- Innovative Microfluidic and Catalytic Techniques Innovation
- Gastric Cancer Management and Outcomes
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
2023-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2023-2025
Università degli Studi della Tuscia
2021-2022
Photo‐catalysts based on the immobilization of meso‐TPP lignin‐nanoparticles were prepared and applied in one‐pot oxidative coupling aromatic amines to N‐alkyl imines. Heterogeneous catalysts effective both homo‐coupling cross‐coupling conditions, affording desired products high yield. Among procedures tested, dialysis method afforded most photo‐catalyst, which was characterized by lower energy gap between HOMO LUMO lignin. Lignin‐nanoparticles alone showed capacity catalyse coupling,...
We report here the synthesis of novel thymine biomimetic photo-adducts bearing an alkane spacer between nucleobases and characterized by antimelanoma activity against two mutated cancer cell lines overexpressing human Topoisomerase 1 (TOP1), namely SKMEL28 RPMI7951. Among them, Dewar Valence showed a selectivity index higher than corresponding pyrimidine-(6-4)-pyrimidone cyclobutane counterpart were highest affinity towards TOP1/DNA complex as evaluated molecular docking analysis. The was...
Chronic exposure to ultraviolet (UV) radiation is known induce the formation of DNA photo-adducts, including cyclobutane pyrimidine dimers (CPDs) and Dewar valence derivatives (DVs). While CPDs usually occur at higher frequency than DVs, recent studies have shown that latter display superior selectivity significant stability in interaction with human DNA/topoisomerase 1 complex (TOP1). With aim deeply investigate mechanism DVs TOP1, we report here four all-atom molecular dynamic simulations...
A dual-target strategy was designed for the application of lignin nanoparticles in lipase mediated biosynthesis novel 3-O-ethyl-L-ascorbyl-6-ferulate and 3-O-ethyl-L-ascorbyl-6-palmitate their successive solvent-shift encapsulation order to improve stability antioxidant activity against temperature pH-dependent degradation. The loaded were fully characterized terms kinetic release, radical scavenging under pH 3 thermal stress (60 °C), showing improved high efficacy protection ascorbic acid...
Abstract A blue‐LED‐driven two‐liquid‐phase system has been set up for the in situ activation of horseradish peroxidase avoiding use hydrogen peroxide and drawbacks related to enzyme denaturation undesired radical side‐reactions. The photobiocatalytic was applied oxidative coupling natural synthetic coumarins bicoumarins, allowing obtain homodimers only one step, tedious protecting groups. Two C‐2 symmetric bicoumarins derived from scopoletin were synthesized first time. UV‐visible...
UVB radiation induces DNA damage generating several thymine photo-adducts (TDPs), which can lead to mutations and cellular transformation. The repair pathways preserve genomic stability by recognizing removing photodamage. These side products may affect processes. We previously synthesized novel biomimetic dimers (BTDs) bearing different alkane spacers between nucleobases. Thus, the present study investigates whether BTDs their TDPs modulate safeguard of primary keratinocytes fibroblasts...
Abstract Pummerer's ketones resembling the tricyclic scaffold of bioactive natural substances were synthesized by blue‐LED driven Horseradish Peroxidase oxidative coupling substituted phenols in 2‐methyltetrahydrofuran using meso ‐tetraphenylporphyrin as photosensitizer and dioxygen primary oxidant. The application functionalized lignin nanoparticles a renewable efficient platform for immobilization enzyme extended effectiveness overall process to heterogeneous catalysis under buffer...
Photoexcitation of pheomelanin produces high-energy singlet oxygen and the superoxide anion, which are reactive species in damage cellular targets. In principle, these can be involved processes synthetic utility when adequate experimental conditions defined. Here, we describe that performs as a selective UVA antenna for horseradish peroxidase oxidative coupling substituted phenols to biologically active Pummerer's ketones under 2-methyltetrahydrofuran/buffer biphasic conditions. this system,...
Abstract Background Soft tissue sarcomas represent a heterogeneous group of rare mesenchymal tumors comprising 1% all solid malignancies. Among them liposarcoma is one the most common histotypes, with atypical lipomatous tumor/well differentiated and dedifferentiated (ALT/WDLPS DDLPS) as major sub entities. The unavailability predictive, prognostic druggable biomarkers make management these lesions challenging. In recent years, CDK4 its inhibitors have emerged potential weapons for...