A5039708520- Sarcoma Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Oral and Maxillofacial Pathology
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Liver Disease and Transplantation
- Vascular Anomalies and Treatments
- Colorectal Cancer Treatments and Studies
- Gastrointestinal disorders and treatments
- COVID-19 Clinical Research Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Tracheal and airway disorders
- Colorectal Cancer Screening and Detection
- Ovarian cancer diagnosis and treatment
- Neurofibromatosis and Schwannoma Cases
- Cardiac, Anesthesia and Surgical Outcomes
- Helicobacter pylori-related gastroenterology studies
- Pancreatic and Hepatic Oncology Research
- Genetic factors in colorectal cancer
- Colorectal Cancer Surgical Treatments
- Intraperitoneal and Appendiceal Malignancies
- Congenital Heart Disease Studies
- Tumors and Oncological Cases
- Aortic Disease and Treatment Approaches
- Animal Disease Management and Epidemiology
Ospedale “M. Bufalini” di Cesena
2021-2025
Azienda Unità Sanitaria Locale Della Romagna
2023
University of Modena and Reggio Emilia
2019-2022
Azienda Ospedaliero-Universitaria di Modena
2018-2022
Azienda Unita' Sanitaria Locale Di Modena
2020
Magna Graecia University
2018
Coronavirus disease 2019 (COVID-19) is a global public health emergency with many clinical facets, and new knowledge about its pathogenetic mechanisms deemed necessary; among these, there are certainly coagulation disorders. In the history of medicine, autopsies tissue sampling have played fundamental role in order to understand pathogenesis emerging diseases, including infectious ones; compared past, histopathology can be now expanded by innovative techniques modern technologies. For first...
Abstract Background Atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS) share clinical, pathological, immunohistochemical molecular features, though PDS is associated with a more aggressive behavior. Methods We reviewed 71 tumors fulfilling criteria for AFX to further stratify their biological potential. Results Lesions were mainly located on the scalps of elderly men, often ulcerated. One case was necrotic, one showed vascular invasion, perineural invasion. Fifty‐one limited...
(1) Background: NRAS mutations affect fewer than 1% of lung adenocarcinomas. The aim this study was to describe the clinicopathological features carcinomas with mutations. (2) Methods: A series NRAS-mutated collected from a molecular diagnostic unit (from four hospitals). cases were analyzed next-generation sequencing. log-rank test for overall survival (OS) calculated. (3) Results: detected in 14/1948 samples (0.72%) non-small-cell 13 patients (8 males, 5 females). involved codon 61...
Post-neoadjuvant therapy (post-NAT) and post-surgical circulating tumor DNA (ctDNA) risk stratification may enhance the management of patients with locally advanced rectal cancer (LARC). In this study, we assessed prognostic value ctDNA-based MRD detection in LARC using a personalized, tumor-informed ctDNA assay. Plasma samples from (N = 30) were analyzed retrospectively Signatera™ The neoadjuvant (NAR) score was calculated compared to status predict recurrence survival outcomes....
Objective This study aims to prospectively compare endoscopic, radiological, and pathological features of a cohort patients with glottic laryngeal squamous cell carcinoma (LSCC) undergoing open partial horizontal laryngectomy (OPHL) type II/III or total better understand the reliability preoperative endoscopy computed tomography (CT) predict inferior paraglottic space (iPGS) involvement. Methods We compared findings in LSCC who underwent OPHL II/III, laryngectomy. Results Endoscopy achieved...
(1) Background. In the differential diagnosis between sarcomatoid carcinoma (SC) and mesothelioma (SM), we aimed to investigate role of Claudin-4 BAP1, a panel recently used distinguish conventional from epithelioid mesothelioma. (2) Methods. We collected 41 surgical pleural biopsies SM, 46 resections SC different sites 49 normal/hyperplastic mesothelium. All cases were tested for BAP1 using immunohistochemistry. The statistical calculations sensitivity, specificity positive negative...
Large rectal lesions can conceal submucosal invasion and cancer nodules. Despite the increasing diffusion of high-definition endoscopes importance an accurate morphological evaluation, a complete assessment in this setting be challenging. Endoscopic ultrasound (EUS) plays established role locoregional staging cancer, although technique has tendency toward over-estimation loco-regional (T) staging. However, there are still few data on contrast-enhanced endoscopic (CH-EUS), especially if...
Abstract Bevacizumab (Bev) plus chemotherapy is a standard first-line treatment in metastatic colorectal cancer (mCRC), however to date no predictive factors of response have been identified. Results our previous analysis on patients enrolled randomized prospective phase III multicenter study (ITACa study) showed value Vascular Endothelial Growth Factor ( VEGF ) polymorphism + 936), 27-nucleotide variable number tandem repeat (VNTR) the endothelial nitric oxide synthase eNOS gene and 894...
Spitzoid tumours have been shown to harbour exclusive kinase fusions. Few studies analysed substantial numbers of ROS1-rearranged lesions. The aim the present study was investigate also their immunohistochemical profile.Among a group 35 spitzoid tumours, which 34 were consecutively diagnosed in 3-year period, we found 11 ROS1 cases that immunohistochemically positive, from 10 patients, eight whom female and two male, who aged 3-52 years (median, 29 years); most lesions (eight) localized on...
Cellular neurothekeoma (CNT) is a dermal lesion with still unknown histogenesis, characterized by immunohistochemical staining for NKI/C3, NSE, MiTF, CD10 and CD68, whereas S100 protein, desmin cytokeratins are negative. Particularly, in several studies NKI/C3 has been reported as strong marker of CNT. We describe herein the clinical, histopathological features two cases morphologically consistent myxoid CNT, one which showing some atypical features, both negative NKI/C3. Our findings stress...
<title>Abstract</title> Extracellular vesicle-driven cancer metastasis represents a therapeutic challenge due to the lack of effective blocking drugs. This study reveals unique mechanism involving P2X7 receptor and A2A/CD39/CD73 axis, which affects ATP adenosine levels in via vesicular release, thereby enhancing metastasis. It also introduces novel P2X7-based approach target tumor release. Indeed, activation on colon carcinoma cells induced release extracellular vesicles carrying P2X7, A2A,...
Abstract Bevacizumab (Bev) plus chemotherapy is a standard first-line treatment in metastatic colorectal cancer (mCRC), however to date no predictive factors of response have been identified. Results our previous analysis on patients enrolled randomized prospective phase III multicenter study (ITACa study) showed value Vascular Endothelial Growth Factor ( VEGF ) polymorphism + 936), 27-nucleotide variable number tandem repeat (VNTR) the endothelial nitric oxide synthase eNOS gene and 894...
Introduction:Postoperative pain is an unpleasant experience for patients after thoracic surgery.It known that these types of surgical procedures cause high intensity pain.Proper nursing assessment the patients' critical as right decision to be made in terms offering quality care and support. Aim:The aim this study was evaluation postoperative experienced by following surgery correlation with demographic characteristics well other factors. Methodology:The McGill questionnaire (long form) used...