A5006732527- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Pancreatic and Hepatic Oncology Research
- Lymphoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Pancreatitis Pathology and Treatment
- Colorectal and Anal Carcinomas
- CAR-T cell therapy research
- Pancreatic function and diabetes
- Lung Cancer Treatments and Mutations
- Gastrointestinal Tumor Research and Treatment
- Helicobacter pylori-related gastroenterology studies
- Cancer Mechanisms and Therapy
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Breast Cancer Treatment Studies
- Esophageal Cancer Research and Treatment
- Celiac Disease Research and Management
- Colorectal Cancer Treatments and Studies
- Immune cells in cancer
- Meningioma and schwannoma management
- Uterine Myomas and Treatments
Ospedale G.B. Morgagni - L.Pierantoni
2020-2025
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
2020-2021
Istituti di Ricovero e Cura a Carattere Scientifico
2020
University of Bologna
2017-2020
Abstract Background Dendritic cells (DCs) are the most efficient antigen-presenting and play a central role in immune system, orchestrating response against tumors. We previously demonstrated that DC-based vaccination effectively induces anti-tumor immunity, yet at same time showing robust safety profile, making this treatment potential candidate for effective adjuvant immunotherapy. To explore possibility, we designed randomized phase II trial (EudraCT no. 2014-005123-27) to provide...
<title>Abstract</title> Next-Generation Sequencing (NGS) has transformed cancer research and clinical practice, with Whole Exome (WES) driving advances in mutational profiling personalized oncology. Yet, transcriptomic signatures remain essential for understanding disease mechanisms, including therapy resistance pathways. RNA sequencing (RNA-seq), however, faces unique challenges when dealing low-input or degraded RNA, as often found archival formalin-fixed paraffin-embedded (FFPE) tissues....
(1) Background: NRAS mutations affect fewer than 1% of lung adenocarcinomas. The aim this study was to describe the clinicopathological features carcinomas with mutations. (2) Methods: A series NRAS-mutated collected from a molecular diagnostic unit (from four hospitals). cases were analyzed next-generation sequencing. log-rank test for overall survival (OS) calculated. (3) Results: detected in 14/1948 samples (0.72%) non-small-cell 13 patients (8 males, 5 females). involved codon 61...
Breast cancer (BC) is the most diagnosed carcinoma and leading cause of death in female over 100 countries. Thanks to advance therapeutic strategies, patients' survival has improved. However, lack response treatments drug resistance are still a main concern, demanding for new approaches, particular advanced stages disease. Androgen receptor (AR) gaining increasing interest as fourth targetable BC, however, its regulation BC cells poorly understood. MicroRNAs (miRNAs) regulate gene expression...
Glycogen synthase kinase-3 beta (GSK-3β) is a serine/threonine kinase involved in glycogen metabolism, cell cycle progression, differentiation, embryogenesis, migration, survival and cellular senescence. Its main biological function to inhibit β-catenin by sequestration promotion of its proteasomal degradation the Wnt canonical pathway; however, GSK-3β interacts with multiple signalling pathways, aberrant expression enzyme was reported many solid neoplasms. This study aimed investigate...
Extracranial metastases from atypical meningioma are rare, and even more so in the liver. We report a case of 68-years-old patient with meningioma, treated partial surgical resection 2012, gamma knife radiotherapy 2014 another hospital, exhibiting liver metastasis 6 years after initial resection.
The majority of patients with Follicular Lymphoma (FL) experience subsequent phases remission and relapse, making the disease "virtually" incurable. To predict outcome FL at diagnosis, various clinical-based prognostic scores have been proposed; nonetheless, they continue to fail for a subset patients. Gene expression profiling has highlighted pivotal role tumor microenvironment (TME) in prognosis; nevertheless, there is still need standardize assessment immune-infiltrating cells...
(1) Background: BRAF mutations affect 4–5% of lung adenocarcinomas. This study aimed to analyze the clinicopathological features carcinomas with mutations, focusing on V600E vs. non-V600E and presence co-mutations. (2) Methods: All BRAF-mutated were retrieved from a molecular diagnostic unit (the reference for four different hospitals). The samples analyzed using next-generation sequencing. Statistical analyses included log-rank tests overall survival (OS) progression-free (PFS). (3)...
Abstract Carcinomas with apocrine differentiation (CAD) of the breast are rare tumours typically presenting high immunohistochemical expression androgen receptor (AR) which is a target molecule for personalised therapy. To date, no studies have evaluated genetic changes that associated AR in CADs. The present work aims to characterise status Twenty CAD were studied immunohistochemistry, situ fluorescence hybridization and DNA methylation analysis, evaluate its regulator status. All...
Circulating tumor cells (CTCs) are a rare population of found in the bloodstream and represent key players metastatic cascade. Their analysis has proved to provide further core information concerning tumor. Herein, we aim at investigating CTCs isolated from 32-year-old patient diagnosed with triple negative spindle-shaped metaplastic breast cancer (MpBC), poorly responsive therapies dismal prognosis. The molecular performed on primary failed underline effective actionable targets address...
Primary squamous cell carcinoma (SCC) can originate in different parts of the body, including head, neck, lung, bronchus, cervix uteri, esophagus, and cardia, subsequently metastasize to stomach. gastric (GSCC) is a rare disease. To better understand GSCC, we present case 72-year-old woman with primary GSCC. A chest abdominal CT scan highlighted 36×26 mm mass 41 longitudinal diameter, which included origin celiac tripod. The disease appeared exophytically from wall. An ultrasound-endoscopy...
Aims We performed a prospective observational study aiming to evaluate the feasibility create tridimensional pancreatic derives organois (PDOs) from EUS guided FNB samples of patients affected by PDAC and correlate derived organoids with native cancer histology. The secondary endpoint our was assess using bile as biological fluid for cell free DNA (cfDNA) investigate landscape cfDNA in plasma PDAC.