A5047482721- Spaceflight effects on biology
- Bone fractures and treatments
- Diversity and Career in Medicine
- Space Exploration and Technology
- 3D Printing in Biomedical Research
- Bone health and osteoporosis research
- Pluripotent Stem Cells Research
- Anesthesia and Neurotoxicity Research
- Sex and Gender in Healthcare
- Pain Mechanisms and Treatments
- Musculoskeletal Disorders and Rehabilitation
- Global Health and Surgery
- Artificial Intelligence in Healthcare and Education
- Body Composition Measurement Techniques
- Blood transfusion and management
- Additive Manufacturing and 3D Printing Technologies
- Health and Medical Research Impacts
- Bone Metabolism and Diseases
- Muscle Physiology and Disorders
- Genetics, Aging, and Longevity in Model Organisms
- Cancer, Stress, Anesthesia, and Immune Response
- Opioid Use Disorder Treatment
- Muscle metabolism and nutrition
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Orthopedic Infections and Treatments
Indiana University – Purdue University Indianapolis
2017-2024
Indiana University School of Medicine
2017-2024
Indiana University
2018-2021
University School
2018
Abstract Gravity has an important role in both the development and maintenance of bone mass. This is most evident rapid intense loss observed humans animals exposed to extended periods microgravity spaceflight. Here, cohabitating 9-week-old male C57BL/6 mice resided spaceflight for ~4 weeks. A skeletal survey these was compared habitat matched ground controls determine effects baseline samples order maturation on resulting phenotype. We hypothesized that weight-bearing bones would experience...
Study Design. A bibliometric analysis. Objective. The aim of this article was to study changes over the last 30 years Spine . These trends are important regarding academic publication productivity. Summary Background Data. Inflation in authorship number and other variables has been described scientific literature. issue author gender is taking on increasing importance, as efforts being made close gap. Methods. From 1985 2015, 10-year incremental data for several were collected, including...
In academia, authorship is considered a currency and important for career advancement. As the Journal of Bone Mineral Research (JBMR) highest-ranked journal in field bone, muscle, mineral metabolism official publication American Society Research, we sought to examine changes over JBMR's 30-year history. Two bibliometric methods were used collect data. The "decade method" included all published manuscripts throughout 1 year each decade past 30 years starting with inaugural year, yielding 746...
Abstract Achieving bone union remains a significant clinical dilemma. The use of osteoinductive agents, specifically morphogenetic proteins (BMPs), has gained wide attention. However, multiple side effects, including increased incidence cancer, have renewed interest in investigating alternatives that provide safer, yet effective regeneration. Here we demonstrate the robust healing capabilities main megakaryocyte (MK) growth factor, thrombopoietin (TPO), and second-generation TPO agents using...
Background and Hypothesis: Soft tissue injury surrounding tibia fractures is a key determinant of surgical care decisions healing outcomes. We have established porcine fracture model with corresponding volumetric muscle loss (VML) in the adjacent peroneus tertius (PT) muscle. Herein, we test hypothesis that without VML induces an initial strength deficit recovers within three months post-injury, while injuries present chronic deficits. Experimental Design or Project Methods: 15 castrated...
Background/Hypothesis: Few large animal bone injury models exist. We present a porcine tibial model of metacritical and critical sized defects for the simulation traumatic injuries. Project Methods: 16 pigs were used in this study. The divided into 3 groups (n=4-8/group). In 12 pigs, 25 mm osteotomy was created tibia space filled with scaffold. 8 scaffolds secured an intramedullary (IM) nail 4 plates. 40 created, scaffold, Fracture healing assessed months post-operatively using Radiographic...
Background and Hypothesis: Injury to soft tissue with volumetric muscle loss (VML) concomitant segmental bone defects (SBDs) can be difficult treat. One potential option is skeletal autograft (SMA). We hypothesize the maximal torque measured in vivo Radiographic Union Scale for Tibial Fractures (RUST) scores will increased VML+SBD+SMA group compared VML+SBD group, but decreased SBD alone. Experimental Design or Project Methods: 18 male, Yucatan minipigs aged 1821 months were randomized into...
Unloading associated with spaceflight results in bone loss and increased fracture risk. Bone morphogenetic protein 2 (BMP2) is known to enhance formation, part, through molecular pathways mechanical loading; however, the effects of BMP2 during remain unclear. Here, we investigated systemic on mice sustaining a femoral followed by housing (International Space Station or ISS) Earth. We hypothesized that spaceflight, weight-bearing bones would be blunted compared observed Nine-week-old male...
Megakaryocytes play a pivotal role in the bone fracture healing process through enhancing osteoblast proliferation, osteoclastogenesis, and angiogenesis. Current repair therapies require direct implantation during surgery (BMP-2, grafts etc.), which has limitations. In order to address this, novel drug, compound MAK122, was created with targeting technology that directs its actions site without needing be implanted surgery, limiting undesirable offsite effects, increasing quantity of drug at...
Non-union bone fracture occurs in 5-10% of injuries. Interventions include surgery with local implantation autograft, allograft, demineralized matrix, and/or morphogenetic proteins. These types injuries are also accompanied by acute and chronic pain states. In most instances, opioids provided to injured patients during after surgery. With the opioid crisis, identifying new analgesic therapies that could reduce or eliminate use, while improving healing is important. Here we show ability a...