A5057182513- RNA and protein synthesis mechanisms
- Chromosomal and Genetic Variations
- CRISPR and Genetic Engineering
- Tuberculosis Research and Epidemiology
- Synthesis and biological activity
- Genomics and Phylogenetic Studies
- Computational Drug Discovery Methods
Cornell University
2020-2021
A recipe for new genes Most lineages contain evolutionarily novel genes, but their origin is not always clear. Cosby et al. investigated the of families lineage-specific vertebrate (see Perspective by Wacholder and Carvunis). Fusion between transposable elements (TEs) host gene exons, once incorporated into genome, could generate functional genes. Examination KARABINER , a bat that arose through this process, shows how retention part TE within allows transcribed protein to bind throughout...
In an era of increasing resistance, new and effective strategies are needed for antibiotic discovery. Whole-cell active screens yield candidate compounds lacking mechanism-of-action (MOA) information thus do not provide biological insight prioritization. We previously reported PROSPECT ( PR imary screening O f S trains to P rioritize E xpanded C hemistry T argets), antimicrobial discovery strategy that measures chemical-genetic interactions between small molecules a pool Mycobacterium...
Abstract How genes with novel cellular functions evolve is a central biological question. Exon shuffling one mechanism to assemble new protein architectures. Here we show that DNA transposons, which are mobile and pervasive in genomes, have provided recurrent supply of exons splice sites protein-coding vertebrates via exon-shuffling. We find transposase domains been captured, primarily alternative splicing, form fusion proteins at least 94 times independently over ∼350 million years tetrapod...