A5006312378- Axon Guidance and Neuronal Signaling
- Angiogenesis and VEGF in Cancer
- Cellular Mechanics and Interactions
- Pharmacological Effects and Toxicity Studies
- Pain Mechanisms and Treatments
- Sexual function and dysfunction studies
Heidelberg University
2022-2024
Abstract Persistent pain is sustained by maladaptive changes in gene transcription resulting altered function of the relevant circuits; therapies are still unsatisfactory. The epigenetic mechanisms and affected genes linking nociceptive activity to transcriptional pathological sensitivity unclear. Here, we found that, among several histone deacetylases (HDACs), synaptic specifically affects HDAC4 murine spinal cord dorsal horn neurons. Noxious stimuli that induce long-lasting inflammatory...
Mature neurons have stable dendritic architecture, which is essential for the nervous system to operate correctly. The ability undergo structural plasticity, required support adaptive processes like memory formation, still present in mature neurons. It unclear what molecular and cellular control this delicate balance between plasticity stabilization. Failures preservation of optimal dendrite structure due atrophy or maladaptive result abnormal connectivity are associated with various...