Medical doctors and researchers in bio-medicine are increasingly confronted with complex patient data, posing new difficult analysis challenges. These data often comprising high-dimensional descriptions of conditions measurements on the success certain therapies. An important question such is to compare correlate therapy results along combinations dimensions. As number dimensions very large, one needs map them a smaller relevant be more amenable for expert analysis. This because irrelevant,...

Functional dyspepsia is a common functional disorder of the gastrointestinal tract that responsible for many primary care visits. No organic changes have been found to explain its symptoms. We hypothesize modern lifestyles and environmental factors, especially psychological stress, play crucial role in high prevalence metabolic syndrome. While diseases are rarely linked disorders, chronic obesity-related syndrome, inflammation, intestinal dysbiosis, significant pathophysiological...

Lack of knowledge and mistrust towards vaccines represent a challenge in achieving the vaccination coverage required for population immunity. The aim this study is to examine opinion that specific demographic groups have about COVID-19 vaccination, order detect potential fears reasons negative attitudes gain on how prepare strategies eliminate possible misinformation could affect vaccine hesitancy. data collection approach was based online questionnaire surveys, divided into three questions...

BACKGROUND This study aimed to identify the clustering of comorbidities, cognitive, and mental factors associated with increased risk pre-frailty frailty in patients ≥60 years a primary healthcare setting eastern Croatia. MATERIAL AND METHODS There were 159 included cluster analysis who underwent four-month follow-up. The first contained 50 patients, second 74 third 35 patients. Clinical parameters identified from electronic health records patient questionnaires. Laboratory tests,...

Atopic dermatitis is the most common chronic inflammatory skin disease. It often first indicator of allergic diseases, and a certain percentage patients are affected by rhinitis and/or asthma as consequence. The study aimed to investigate link between atopic comorbidity in family medicine. In specialist medicine practice Osijek, retrospective was conducted period from January 1, 2016 July 2017 on with total number patients, their comorbid diseases. data source E-chart. results showed that...

In this article, we demonstrate the impact of interactive machine learning: develop biomedical entity recognition dataset using a human-into-the-loop approach. contrary to classical learning, human-in-the-loop approaches do not operate on predefined training or test sets, but assume that human input regarding system improvement is supplied iteratively. Here, during annotation, learning model built previous annotations and used propose labels for subsequent annotation. To such iterative...

The spectrum, intensity, and overlap of symptoms between functional gastrointestinal disorders (FGIDs) other characterize patients with FGIDs, who are incredibly different in their backgrounds. An additional challenge regard to the diagnosis FGID applicability a given treatment is ongoing expansion risk factors believed be connected these disorders. Many cytokines inflammatory cells have been found cause continuous existence low level inflammation, which thought basic pathophysiological...

Antibiotics are the widely prescribed drugs for children and most likely to be related with adverse reactions. Record on reactions allergies from antibiotics considerably affect prescription choices. We consider this a biomedical decision-making problem explore hidden knowledge in survey results data extracted big pool of health records children, Health Center Osijek, Eastern Croatia.

BACKGROUND:Physical frailty, cognitive impairment, and symptoms of anxiety depression frequently co-occur in later life, but, to date, each has been assessed separately. The present study their patterns primary care patients aged ≥60 years. MATERIAL AND METHODS:This cross-sectional evaluated 263 years eastern Croatia 2018. Physical depression, were using the Fried phenotypic model, Mini-Mental State Examination (MMSE), Geriatric Anxiety Scale (GAS), Depression (GDS), respectively. Patterns...

The role of the cytokine interleukin-37 (IL-37) has been recognized in reversing inflammation-mediated metabolic costs. aim was to evaluate clinical utility this as a diagnostic and prognostic marker patients with type 2 diabetes (T2D).

(1) Objectives: We aimed to identify clusters of physical frailty and cognitive impairment in a population older primary care patients correlate these with their associated comorbidities. (2) Methods: used latent class analysis (LCA) as the clustering technique separate different stages mild (MCI) into clusters; differences were assessed by using multinomial logistic regression model. (3) Results: Four (latent classes) identified: highly functional (the mean SD “frailty” test 0.58 ± 0.72...

Abstract Background Aging is associated with many personal, social, and environmental challenges that increase the risk of loneliness. Loneliness a painful emotional experience perceived lack connection intimacy. accelerates health deterioration, but presence chronic conditions (comorbidities) in older individuals may potentiate feeling The relationships between status loneliness have not been assessed an integrated manner, although it necessary for planning efficient interventions. aim this...

The impact of hypertension duration and the time onset on expression metabolic syndrome (MS) other CV risk factors, in perimenopausal women, have not been studied so far. Methods. A total 202 old 47-59 years, diagnosed with hypertension, were recruited from primary care practices eastern Croatia. categories defined as <5, 5-10, >10 years. Data analyzed by standard statistical procedures.The proportion women MS increases parallel (p = 0.025). Among examined significant increase was found for...