A5103147242- Nitric Oxide and Endothelin Effects
- Ion Channels and Receptors
- Barrier Structure and Function Studies
- Ion channel regulation and function
- Ion Transport and Channel Regulation
- Erythrocyte Function and Pathophysiology
- Cardiovascular Health and Disease Prevention
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Heart Rate Variability and Autonomic Control
- Complement system in diseases
- Connexins and lens biology
- Blood Coagulation and Thrombosis Mechanisms
- Trypanosoma species research and implications
- Photoreceptor and optogenetics research
- Circadian rhythm and melatonin
- Mosquito-borne diseases and control
- Cardiac electrophysiology and arrhythmias
University of Maryland, Baltimore
2020-2022
Universidade Federal de Minas Gerais
2016-2021
Despite the abundance of capillary thin-strand pericytes and their proximity to neurons glia, little is known contributions these cells control brain hemodynamics. We demonstrate that pharmacological activation pericyte KATP channels profoundly hyperpolarizes cells, dilates upstream penetrating arterioles arteriole-proximate capillaries, increases blood flow. Focal stimulation with a channel agonist sufficient evoke this response, mediated via KIR2.1 channel-dependent retrograde propagation...
The development of new calcium channel blockers is still relevant for the understanding their physiological role and pharmacological therapeutic purposes. For this task, natural products represent a source drugs. present work investigated mechanism structural relationship vasodilator effect riparins I, II III in mouse small mesenteric artery. Riparins induced an endothelium-independent concentration-dependent arteries. were more potent than riparin suggesting these All inhibited contractile...
SUMMARY Capillary pericytes and their processes cover ∼90% of the total length brains capillary bed. Despite abundance, little is known pericyte function, contributions to control brain hemodynamics remain unclear. Here, we report that deep possess a mechanistic ‘energy switch’ that, when activated by decrease in glucose, elicits robust K ATP channel activation increase blood flow protect energy substrate availability. We demonstrate pharmacological channels profoundly hyperpolarizes leads...
Triatoma infestans (Hemiptera: Reduviidae) is a hematophagous insect and the main vector of Trypanosoma cruzi (Kinetoplastida: Trypanosomatidae). In present study, authors investigated whether serine protease activity from saliva T. has role in vasomotor modulation, insect-blood feeding by cleaving activating protease-activated receptors (PARs).T. was chromatographed as previously reported for purification triapsin, protease. The cleavage triapsin on PAR peptides based FRET technology. Mass...
Caffeine is a methylxanthine with multiple actions in vascular smooth muscle cells (VSMCs), including the increase intracellular Ca2+ (iCa2+) concentration by activation of ryanodine receptors (RyRs). The present study aimed at investigating participation Ca2+-influx through different Ca2+-channels on transient contraction (TC) induced caffeine mice mesenteric arteries.Second-order arteries was isolated from male Swiss mice. Vessels without functional endothelium were stimulated (10 mM)....
Neuronal computation is metabolically expensive and relies on the timely delivery of energy substrates via tightly controlled blood flow to prevent energetic deficits. The range mechanisms responsible for this coupling neural activity are collectively termed ‘neurovascular coupling’ (NVC). These NVC typically assumed be invariant possibility that they may plastic, allowing reshaping according ever-shifting neuronal metabolic needs, has not been considered. We present evidence resculpts...
The sarcoplasmic reticulum (SR)/plasma membrane (PM) junction plays an important role in the control of excitation‐contraction coupling vascular smooth muscle cells (VSMCs). present work investigated PM/SR interaction involved modulation contraction induced by activation ryanodine receptors (RyRs) mouse mesenteric artery. 2 nd branch endothelium‐denuded small arteries from male Swiss mice (10–12 weeks old) were studied using wire myography, epifluorescence microscopy, and electrophysiology...