A5087653045- Medical and Biological Ozone Research
- Liver physiology and pathology
- Aldose Reductase and Taurine
- Diet, Metabolism, and Disease
- Autophagy in Disease and Therapy
- Ovarian cancer diagnosis and treatment
- Spaceflight effects on biology
- Bioactive Compounds and Antitumor Agents
- Reproductive Biology and Fertility
- Organ Transplantation Techniques and Outcomes
- Phytochemical and Pharmacological Studies
- Tannin, Tannase and Anticancer Activities
- Botanical Studies and Applications
- Hydrogen's biological and therapeutic effects
- Chemotherapy-induced organ toxicity mitigation
- Cannabis and Cannabinoid Research
- Sirtuins and Resveratrol in Medicine
- Natural product bioactivities and synthesis
- Ovarian function and disorders
- Mesenchymal stem cell research
- Inflammatory mediators and NSAID effects
- Phytochemicals and Antioxidant Activities
- Nigella sativa pharmacological applications
- Prenatal Substance Exposure Effects
Gazi University
2020-2024
Middle East Technical University
2013-2016
The bark from Salix species of plants has been traditionally consumed for its antiinflammatory properties. Because inflammation frequently accompanies the progress colorectal cancer (CRC), we have evaluated anticancer properties ethanolic extract (EEB) S. aegyptiaca, a endogenous to Middle East, using HCT-116 and HT29 CRC cell lines. Fresh aegyptiaca was extracted with ethanol, fractionated by solvent-solvent partitioning fractions were analyzed tandem mass spectrometry. Catechin, catechol,...
Background and Objectives: Sepsis its related complications are associated with high morbidity mortality, often leading to liver damage. Ozone, a molecule anti-inflammatory antioxidant properties, may offer protective effects. This study aimed evaluate the therapeutic impact of ozone on injury in rat model sepsis induced by cecal ligation perforation (CLP). Material Methods: A total 36 rats were randomly divided into five groups: control (Group C), O), CLP), + O+CLP), CLP+O). In groups, 4 mL...
Based on overlapping structural requirements for both efficient aldose reductase inhibitors and PPAR ligands, [5-(benzyloxy)-1H-indol-1-yl]acetic acid (compound 1) was assessed inhibition of ability to interfere with PPARγ.Aldose by 1 characterized IC 50 in submicromolar low micromolar range, rat human enzyme, respectively.Selectivity relation the closely related kidney aldehyde approx.factor 50.At organ level isolated lenses, compound significantly inhibited accumulation sorbitol a...
We have previously shown that ethanolic extract from bark (EEB) of Salix aegyptiaca (Musk Willow) can inhibit proliferation and motility induce apoptosis in colon cancer cells. Tandem mass spectrometry revealed EEB to be rich catechin, catechol, salicin. The present study investigated the chemopreventive effect HPLC-fingerprinted on 1,2-dimethylhydrazine (DMH)-induced aberrant crypt foci (ACF) formation mice. DMH (20 mg/kg body weight) was weekly injected subcutaneously mice for first 2...
ÖZLiver injury is commonly seen in the population depending on drug and chemical usage.Different groups of drugs chemicals lead to different pathogeneses liver, such as necrosis, fibrosis, or inflammation.Although liver has a high regenerative capability, drug-and chemical-induced may result organ failure.Because limitations transplantation, therapy methods alternative transplantation still need be studied.Owing their differentiation regeneration abilities, mesenchymal stem cells (MSCs) have...
OBJECTIVE: Carboplatin is a commonly used chemotherapeutic agent. Kidneys are an important organ affected by the adverse effects of agents. This study aimed to investigate protective effect Nigella sativa oil (NSO) against kidney damage due carboplatin exposure.MATERIAL AND METHODS: All animals (n=24 female wistar-albino rats) were divided into four groups; 4 ml/kg saline was intraperitoneally (i.p.) administered on day one and two in first group. NSO i.p. second group.4 80 mg/kg third...