A5080557465- Photorefractive and Nonlinear Optics
- Photonic and Optical Devices
- Liquid Crystal Research Advancements
- Innovative Microfluidic and Catalytic Techniques Innovation
- Advanced Fiber Laser Technologies
- Nanotechnology research and applications
- Protein purification and stability
- Microfluidic and Capillary Electrophoresis Applications
- Microplastics and Plastic Pollution
- Analytical Chemistry and Sensors
- Advanced Optical Imaging Technologies
- Electrowetting and Microfluidic Technologies
- Nanoparticles: synthesis and applications
Amgen (United States)
2024
Technological University Dublin
2018-2022
Herein, we report the development of an integrated continuous manufacturing (CM) process for penultimate step in synthesis apremilast, drug substance (DS) commercial product Otezla. This effort was motivated by desire to create alternative configuration with a significantly smaller footprint and impart intensification resulting more sustainable process. Three primary aspects existing batch had be addressed achieve this goal: (1) long reaction time, (2) low solubility starting materials...
The aim of this paper is to discuss the benefits as well limitations utilizing photopolymer materials in design holograms that are responsive changes their environment, such concentration a specific substance, temperature, and pressure. Three different case studies presented, including both surface volume phase holograms, order demonstrate flexibility approach holographic photopolymers for sensors interactive optical devices. First, functionalized relief hologram demonstrated operate an...
Functionalised holograms are important for applications utilising smart diffractive optical elements light redirection, shaping and in the development of sensors/indicators. This paper reports on holographic recording novel magnetic nanocomposites observed temperature change dry layers liquid samples exposed to alternating field (AMF). The nanocomposite consists N-isopropylacrylamide (NIPA)-based polymer doped with nanoparticles (MNPs), local heating is achieved through induction. Here,...
Herein, the dynamics and reversibility of temperature‐induced changes in volume phase holographic gratings (VPHGs) recorded low‐toxicity self‐processing photopolymer poly( N ‐isopropyl acrylamide) (poly‐NIPA) are reported on. Transmission reflection exposed to temperatures ranging 8–60 °C study effect temperature on their properties. First, role chemical composition is investigated by comparing layers containing NIPA with those acrylamide (AA) measuring normalized diffraction efficiency (DE)...
Recently, functionalised photopolymer has emerged as a versatile recording material in the field of optical holography due to its novel characteristics and potential use development holographic based sensors, elements. This work describes temperature response newly developed photopolymer, containing monomer N-isopropylacrylamide (NIPA) which under photopolymerisation forms sensitive polymer - Poly(N-isopropylacrylamide) (PNIPA). The photonic sensor was by volume phase transmission gratings...
Photopolymer nanocomposite materials utilising nanoparticles of varied refractive index are one the most attractive for holography due to their tuneable properties. The preparation photopolymer nanocomposites can involve mixing a stable colloidal suspension in solution or printing nanoparticle on top dried layer. By following first approach this study novel material is prepared holographic recording. It consists N-isopropylacrylamide (NIPA)-based as host and iron oxide magnetic nanodopant....
Holographic recording materials can be utilised in the fabrication of microstructures for use as sensors [1,2]. In order to achieve this holographic material/structure has functionalized by incorporation a chemical component providing sensitivity specific analyte/stimuli. We introduce different approaches photosensitive material/photonic structure functionalization and present experimental results two examples sensing devices: selective detection sodium potassium ions temperature indicator...
Materials research in holography has attracted significant interest and is aiming at facilitating the development of light-weight, cost effective optical devices. Among most researched materials, photopolymers are playing an indispensable role due to many advantages they offer such as their self-processing nature, high spectral sensitivity relatively inexpensive mass production cost; hence extensively studied make possible applications holographic technology interferometry [1], solar...