A5029207967- Geriatric Care and Nursing Homes
- Palliative Care and End-of-Life Issues
- Frailty in Older Adults
- Interprofessional Education and Collaboration
- Axon Guidance and Neuronal Signaling
- Innovative Human-Technology Interaction
- Dementia and Cognitive Impairment Research
- Health Systems, Economic Evaluations, Quality of Life
- Technology Use by Older Adults
- Persona Design and Applications
- Primary Care and Health Outcomes
- Mental Health and Patient Involvement
- Neonatal Health and Biochemistry
- Health Policy Implementation Science
- Metabolism and Genetic Disorders
- Discourse Analysis in Language Studies
- Nutrition and Health in Aging
- Chronic Disease Management Strategies
- Infant Nutrition and Health
- Assistive Technology in Communication and Mobility
- Occupational Therapy Practice and Research
- Lanthanide and Transition Metal Complexes
- Protein Interaction Studies and Fluorescence Analysis
- PI3K/AKT/mTOR signaling in cancer
- Neurological diseases and metabolism
University of Nottingham
2016-2025
NIHR Applied Research Collaboration West
2023-2024
Centre for Inflammation Research
2023
NIHR Clinical Research Network
2019-2023
Institute of Mental Health
2016-2023
Nottingham Biomedical Research Centre
2019-2020
NIHR Applied Research Collaboration Greater Manchester
2020
National Institute for Health Research
2015-2019
Berkshire Healthcare NHS Foundation Trust
2016
Peninsula College of Medicine and Dentistry
2011
Distinct changes in glycogen synthase kinase-3 (GSK-3) signalling can regulate neuronal morphogenesis including the determination and maintenance of axonal identity, are required for neurotrophin-mediated axon elongation. In addition, we have previously shown a dependency on GSK-3 activation semaphorin 3A (Sema3A)-mediated growth-cone-collapse response sensory neurons. Regulation activity involves intermediate lipid phosphatidylinositol 3,4,5-trisphosphate, which be modulated by 3-kinase...
The regeneration kinetics of the integral membrane protein bacteriorhodopsin have been investigated in a lipid-based refolding system. Previous studies on involved detergent-based systems, and particular mixed dimyristoylphosphatidylcholine (DMPC)/CHAPS micelles. Here, we show that short chain lipid dihexanoylphosphatidylcholine (DHPC) can be substituted for detergent CHAPS regenerated to high yield DMPC/DHPC Bacteriorhodopsin are measured Rapid, stopped flow mixing is employed initiate...
A recent (2016) Office for National Statistics report stated that dementia is now "the leading cause of death" in England and Wales. Ever fixated with the syndrome (an unfailingly newsworthy topic), British press was quick to respond bulletin, consistently headlining nation's "biggest killer," while (re)formulating other aspects distorting emotive metaphorical terms. In this paper we examine how media, through use a recurring set linguistic visual semiotic tropes, portrayed as an agentive...
Background: Complications due to frailty and injury after falls are a significant problem for people living in residential aged care. This can lead range of negative outcomes including poor physical, social, psychological well-being. The Australian Royal Commission into Aged Care Quality Safety highlighted many aspects care homes requiring improvement, leading specific recommendations aimed at improving the this area. contributed four calling increased allied health interventions meet unmet...
ObjectivesFirst point of contact physiotherapy (FPCP) provides patients direct access to a physiotherapist. Literature demonstrates efficacy FPCP. Evidence has highlighted the need for cultural shifts from both patient and professional perspectives optimise This study explored stakeholder perceptions awareness understanding FPCP better inform implementation.Design, setting, participantsA qualitative methodology utilised semi-structured interviews focus groups. Findings previous realist...
Quality improvement collaboratives (QICs) bring together multidisciplinary teams in a structured process to improve care quality. How QICs can be used support healthcare homes is not fully understood.A realist evaluation develop and test programme theory of how work homes. A multiple case study design considered implementation across 4 sites 29 Observations, interviews focus groups captured contexts mechanisms operating within QICs. Data analysis classified emerging themes using...
Inositol-1,4,5-trisphosphate (InsP<sub>3</sub>) depletion has been implicated in the therapeutic action of bipolar disorder drugs, including valproic acid (VPA). It is not currently known whether effect VPA on InsP<sub>3</sub> related to deleterious effects teratogenicity or elevated viral replication, if it occurs via putative inhibitory glycogen synthase kinase-3β (GSK-3β). In addition, structural requirements VPA-related compounds cause are unknown. current study, we selected a set 10...
The Breakthrough Series Quality Improvement Collaborative (QIC) initiative is a well-developed and widely used approach, but most of what we know about it has come from healthcare settings. In this article, those leading QICs to improve care in homes provide detailed accounts six share their learning applying the QIC approach home sector. Overall, five home-specific lessons were learnt: (i) plan for resources needed support collaborative teams with collecting, processing, interpreting data;...
Introduction This protocol describes a study of quality improvement collaborative (QIC) to support implementation and delivery comprehensive geriatric assessment (CGA) in UK care homes. The QIC will be formed health social professionals working with homes supported by clinical, research specialists. participants receive training using the Model for Improvement. An appreciative approach encouraged through facilitated shared learning events, coaching assistance project evaluation. Methods...
:Background: Technology-enabled healthcare or smart health has provided a wealth of products and services to enable older people monitor manage their own conditions at home, thereby maintaining independence, whilst also reducing costs. However, despite the growing ubiquity health, innovations are often technically driven, user does not have input into design. The purpose current study was facilitate debate about positive negative perceptions attitudes towards digital technologies. Methods:...
Aim This exploratory study of commissioning third sector services for older people aimed to explore whether service data was fed back commissioners and this could improve intelligence about the population hence inform future decisions. Background Third are provided through charities non-profit community organizations, over recent years have developed that assess advise self-management or provide wellbeing support in community. an opportunity reach vulnerable populations them. Some state...
Equality of access to memory assessment services by older adults from ethnic minorities is both an ethical imperative and a public health priority.To investigate whether timeliness service differs between people white British South Asian ethnicity.Longitudinal cohort.Nottingham Memory Study; outpatient secondary mental healthcare.Our cohort comprised 3654 32 outpatients.The criterion for timely was set at 90 days referral. Relationships ethnicity likelihood were analysed using binary...
Background: Care home residents should be offered opportunities to participate in meaningful activities an environment of their choice (National Institute for Health and Excellence, 2013).Whilst outdoor mobility are believed have health-related benefits, UK best practice recommendations based on expert consensus.This research aimed map the literature this field identify gaps evidence base.Methods: A systematic mapping review was conducted.The following databases were searched from inception...
Abstract We have used the membrane‐localized calcium probe fura‐piperazine‐C 12 H 25 (FFP‐18) to examine cytosolic concentrations in a volume close plasmalemma. Although promotion of axon outgrowth by cell adhesion molecules requires extracellular and is correlated with an opening plasmalemmal channels, conventional indicators cannot detect change concentration such stimulated growth cones. examined signalling chick retinal ganglion cones extending along stripes N‐cadherin. Subplasmalemmal...