A5038428072- Bone and Joint Diseases
- Osteoarthritis Treatment and Mechanisms
- Bone health and treatments
- Bone and Dental Protein Studies
- Hematological disorders and diagnostics
- Alkaline Phosphatase Research Studies
- Cancer-related molecular mechanisms research
- dental development and anomalies
- Bone health and osteoporosis research
- Cancer-related gene regulation
- Growth Hormone and Insulin-like Growth Factors
- Total Knee Arthroplasty Outcomes
- Adipose Tissue and Metabolism
- Scientific and Engineering Research Topics
- Neurogenetic and Muscular Disorders Research
- Lower Extremity Biomechanics and Pathologies
- Metabolism and Genetic Disorders
- Helicobacter pylori-related gastroenterology studies
- Peroxisome Proliferator-Activated Receptors
- Gastroesophageal reflux and treatments
- Bone Metabolism and Diseases
- Muscle Physiology and Disorders
- Dental Implant Techniques and Outcomes
- Dental materials and restorations
- Ion Transport and Channel Regulation
University of Oslo
2012-2020
Oslo University Hospital
2013
The aim of this study was to describe the expression genes, including ameloblastin (Ambn), amelogenin X chromosome (Amelx), and enamelin (Enam) during early (pre-secretory) tooth development. these genes has predominantly been studied at post-secretory stages. Deoxyoligonucleotide microarrays were used gene development murine first molar germ 24 h intervals, starting 11th embryonic day (E11.5), up 7th after birth (P7). profile search function Spotfire software select with similar as enamel...
Biofilm formation on dental abutment may lead to peri-implant mucositis and subsequent peri-implantitis. These cases are clinically treated with antibiotics such as doxycycline (Doxy). Here we used an electrochemical method of cathodic polarization coat Doxy onto the outer surface a material. The Doxy-coated showed burst release in phosphate-buffered saline during first 24 h. However, significant amount remained for at least 2 weeks especially 5 mA-3 h sample higher amount, suggesting both...
Estrogen deficiency promotes bone loss and skeletal muscle dysfunction. Peroxisome proliferator-activated receptors (PPARs) have 3 subtypes (α, δ, γ). PPARγ agonists induce loss, whereas PPARα increase mass. Although PPARδ are known to influence metabolism, the effects unsettled. This study investigated musculoskeletal of agonist GW501516 in ovariectomized (OVX) rats. Female Sprague Dawley rats, 12 weeks age, were allocated a sham-operated group OVX groups; high-dose (OVX-GW5), low-dose...
Abstract Aim To assess tissue level changes of proteome and cytokine profiles subchondral bone in hip osteoarthritis (OA) affected by marrow lesions (BMLs). We compared significant protein differences osteoarthritic with BMLs to control without lesions. Methods Subchondral biopsies were taken from femoral heads end‐stage patients (BML, n = 21) (CON, 9) BMLs. Proteins extracted through a standardized Trizol protocol used the subsequent analyses. Angiogenesis markers assessed using multiplex...
Long-term antiresorptives use has been linked to atypical subtrochanteric and diaphyseal femoral fractures (AFF), the pathogenesis of which is still unknown. In present case report we results analysis bone chips from a 74-year old female patient that had on alendronate, ibandronate denosumab treatment, who sustained an fracture, by histology, quantitative backscattered electron imaging, Raman spectroscopic analysis. The indicate ongoing osteoclastic resorption, but also several...
Epidemiological studies suggest an increased fracture risk in patients taking proton pump inhibitors (PPIs) for long term. The underlying mechanism, however, has been disputed. By binding to the gastric pump, PPIs inhibit acid secretion. We have previously shown that (H(+)/K(+)ATPase beta subunit) KO mice exhibit reduced bone mineral density (BMD) and inferior strength compared with WT mice. Patients using as well these hypoacidity, subsequently serum concentrations of hormone gastrin. In...
Objectives Little is known about tissue changes underlying bone marrow lesions (BMLs) in non-weight-bearing joints with osteoarthritis (OA). Our aim was to characterize BMLs OA of the hand using dynamic histomorphometry. We therefore quantified turnover and angiogenesis subchondral at base thumb, compared findings control from hip OA. Methods Patients or hip, underwent preoperative MRI assess BMLs, tetracycline labelling determine turnover. Three groups were compared: trapezium bones removed...
The main objective of this study was to map global gene expression in order provide information about the populations mRNA species participating murine tooth development at 24 h intervals, starting 11th embryonic day (E11.5) up 7th post-natal (P7). levels RNA expressed during were mesured using a total 58 deoxyoligonucleotide microarrays. Microarray data validated real-time RT-PCR. Differentially genes (p < 0.05) subjected bioinformatic analysis identify cellular activities significantly...
Searchable abstracts of presentations at key conferences on calcified tissues ISSN 2052-1219 (online)
Searchable abstracts of presentations at key conferences on calcified tissues ISSN 2052-1219 (online)