A5046973708- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Evolutionary Game Theory and Cooperation
- Neurotransmitter Receptor Influence on Behavior
- Evolutionary Psychology and Human Behavior
- Treatment of Major Depression
- Tryptophan and brain disorders
- Pharmacological Receptor Mechanisms and Effects
- Olfactory and Sensory Function Studies
- Diet and metabolism studies
- Primate Behavior and Ecology
- Cancer, Stress, Anesthesia, and Immune Response
Maj Institute of Pharmacology
2020-2024
Polish Academy of Sciences
2020-2024
Abstract Prosocial behavior, defined as voluntary behavior intended to benefit another, has long been regarded a primarily human characteristic. In recent years, it was reported that laboratory animals also favor prosocial choices in various experimental paradigms, thus demonstrating behaviors are evolutionarily conserved. Here, we investigated adult male and female C57BL/6 mice task where subject mouse equally rewarded for entering any of the two compartments cage, but only compartment...
Background: In humans, adolescence is a time of dynamic behavioral and emotional changes, including transient decrease in affect associated with being among family members. It not clear if similar change occurs rodent species used to model human psychiatric disorders. Here, we investigated the developmental profile reward value interactions siblings across mice. Methods: Social conditioned place preference test was performed male mice representing early (around postnatal day 33 [P33]),...
Oprm1, the gene encoding μ-opioid receptor, has multiple reported transcripts, with a variable 3' region and many alternative sequences C-terminus of protein. The functional implications this variability remain mostly unexplored, though recurring notion is that it could be exploited by developing selective ligands improved clinical profiles. Here, we comprehensively examined Oprm1 transcriptional variants in murine central nervous system, using long-read RNAseq as well spatial single-cell...
Abstract Social interactions can be and often are rewarding. The effect of social contact strongly depends on circumstances, the reward may driven by varied motivational processes, ranging from parental or affiliative behaviors to investigation aggression. Reward associated with nonreproductive in rodents is measured using conditioned place preference (sCPP) paradigm, where a change for an initially neutral context confirms reinforcing effects contact. Here, we revised sCPP method reexamined...
Abstract In humans, adolescence is a time of dynamic behavioral changes, including transient decrease in affect associated with being among family members. Here, we found that the reward value interactions siblings adolescent male mice followed similar course to humans: high preadolescence, mid-adolescence and return initial level late adolescence, as observed social conditioned place preference task. The change was specific interaction, rewarding effect cocaine actually increased during...
Opioid signaling controls the activity of brain's reward system. It is involved in hedonic effects rewards and has essential roles reinforcement motivational processes. Here, we focused on opioid through mu delta receptors dopaminoceptive neurons evaluated role these play reward-driven behaviors. We generated a genetically modified mouse with selective double knockdown expressing dopamine receptor D1. Selective expression transgene was confirmed using immunostaining. Knockdown validated by...
Repeated administration of subanesthetic doses ketamine is a model psychosis-like state in rodents. In mice, this treatment produces range behavioral deficits, including impairment social interactions and locomotion. To date, these phenotypes were described primarily the Swiss C3H/HeHsd mouse strains. A few studies investigated ketamine-induced behaviors C57BL/6J strain, but to our knowledge C57BL/6N strain was not thus far. This surprising, as both C57BL/6 sub-strains are widely used...
Abstract Background Oprm1 , the gene encoding μ-opioid receptor, has multiple reported transcripts, with a variable 3 region and many alternative sequences C-terminus of protein. The functional implications this variability remain mostly unexplored, though recurring notion is that it could be exploited by developing selective ligands improved clinical profiles. Here, we comprehensively examined transcriptional variants in murine central nervous system. Methods RNA-seq transcription analyses...
Abstract Social interactions can be and often are rewarding. The effect of social contact strongly depends on circumstances, the reward may driven by varied motivational processes, ranging from parental or affiliative behaviors to investigation aggression. Reward associated with nonreproductive in rodents is measured using conditioned place preference (sCPP) paradigm, where a change for an initially neutral context confirms reinforcing effects contact. Here, we revised sCPP method reexamined...
Abstract Prosocial behavior, defined as voluntary behavior intended to benefit another, has long been regarded a primarily human characteristic. In recent years, it was reported that laboratory animals also favor prosocial choices in various experimental paradigms, thus demonstrating behaviors are evolutionarily conserved. Here, we investigated adult male and female C57BL/6 mice task where subject mouse is equally rewarded for entering any of the two compartments cage, but only compartment...
Repeated administration of subanesthetic doses ketamine is a model psychosis-like state in rodents. In mice, this treatment produces range behavioral deficits, including impairment social interactions and locomotion. To date, these phenotypes were described primarily the Swiss C3H/HeHsd mouse strains. A few studies investigated ketamine-induced behaviors C57BL/6J strain, but to our knowledge C57BL/6N strain was not thus far. This surprising, as both C57BL/6 strains are widely used...