A5065396311- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- Regulation of Appetite and Obesity
- Nerve injury and regeneration
- Menopause: Health Impacts and Treatments
- Axon Guidance and Neuronal Signaling
- Stress Responses and Cortisol
- Estrogen and related hormone effects
- Mitochondrial Function and Pathology
- Autophagy in Disease and Therapy
- Neurological Disease Mechanisms and Treatments
- Biochemical effects in animals
- Diet and metabolism studies
- Nuclear Receptors and Signaling
- Adipose Tissue and Metabolism
- Galectins and Cancer Biology
- Advanced Glycation End Products research
- Macrophage Migration Inhibitory Factor
- Medical research and treatments
- Medicinal Plants and Bioactive Compounds
- Hypothalamic control of reproductive hormones
- Adipokines, Inflammation, and Metabolic Diseases
- bioluminescence and chemiluminescence research
Fundación Ciencias Exactas y Naturales
2012-2024
University of Buenos Aires
2006-2024
Experimental Medicine and Biology Institute
2013-2024
Consejo Nacional de Investigaciones Científicas y Técnicas
2013-2024
National Academies of Sciences, Engineering, and Medicine
2006-2009
Background Several brain disturbances have been described in association to type 1 diabetes humans. In animal models, hippocampal pathological changes were reported together with cognitive deficits. The exposure a variety of environmental stimuli during certain period time is able prevent alterations and improve learning memory conditions like stress, aging neurodegenerative processes. Methodology/Principal Findings We explored the modulation streptozotocin-induced diabetic mice by...
Abstract Cerebral dysfunctions, including a high incidence of depression, are common findings in human type 1 diabetes mellitus. An association between depression and defective hippocampal neurogenesis has been proposed and, rodents, antidepressant therapy restores neuronal proliferation the dentate gyrus. Hippocampal is also deficient diabetic mice, which led us to study whether selective serotonin reuptake inhibitor fluoxetine influences cell streptozotocin‐diabetic animals. Diabetic...
In the context of Alzheimer's disease (AD), hippocampal alterations have been well described in advanced stages pathology, when amyloid deposition, inflammation and glial activation occur, but less attention has directed to studying early brain behavioral changes. Using an animal model AD, transgenic PDAPP-J20 mouse at 5 months age, no plaques are present low cerebral levels peptides detectable, we found structural, morphological, cellular hippocampus. Young mice showed a reduced volume with...
Mitochondria are dynamic organelles that undergo fusion and fission processes. These events regulated by mitochondria-shaping proteins. Changes in the expression and/or localization of these proteins lead to a mitochondrial dynamics impairment may promote apoptosis. Increasing evidence correlates disruption with occurrence neurodegenerative diseases. Therefore, we focused on this topic Manganese (Mn)-induced Parkinsonism, disorder associated Mn accumulation preferentially basal ganglia where...
Alzheimer's disease (AD) is a progressive neurodegenerative without effective therapy. Brain amyloid deposits are classical histopathological hallmarks that generate an inflammatory reaction affecting neuronal and glial function. The identification of early cell responses brain areas involved could help to design new successful treatments. Hence, we studied alterations hippocampal glia their progression during the neuropathology in PDAPP-J20 transgenic mice, AD model, at 3, 9, 15 months (m)...
Abstract Type 1 diabetes mellitus correlates with several brain disturbances, including hypersensitivity to stress, cognitive impairment, increased risk of stroke and dementia. Within the central nervous system, hippocampus is considered a special target for alterations associated diabetes. Neurogenesis plastic event restricted few adult areas: subgranular zone dentate gyrus subventricular (SVZ). First, we studied ability neurogenesis in SVZ chronic diabetic mice induced by streptozotocin...
Dietary restriction promotes cell regeneration and stress resistance in multiple models of human diseases. One the conditions that could potentially benefit from this strategy is Alzheimer's disease, a chronic, progressive prevalent neurodegenerative disease. Although there are no effective pharmacological treatments for pathology, lifestyle interventions play therapeutic roles. Our objectives were 1) to evaluate effects dietary on cognition, hippocampal amyloid deposition, adult...
The hippocampus, a limbic structure linked to higher brain functions, appears vulnerable in diabetic subjects that have risk of stroke, dementia, and cognitive decline. dentate gyrus (DG) the hippocampus is one limited neurogenic areas during adulthood; neurons born DG are involved some types learning memory processes. We found decrease ability for proliferation neuronal differentiation newborn cells, measured by bromodeoxyuridine incorporation DG, from streptozotocin‐induced mice. hilar...
Subtype 3 metabotropic glutamate receptor (mGlu3R) displays a broad range of neuroprotective effects. We previously demonstrated that mGlu3R activation in astrocytes protects hippocampal neurons from Aβ neurotoxicity through stimulation both neurotrophin release and uptake. Alternative-spliced variants were found human brains. The most prevalent variant, mGlu3Δ4, lacks exon 4 encoding the transmembrane domain can inhibit ligand binding to mGlu3R. To date, neither its role neurodegenerative...