A5016551272- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Regulation of Appetite and Obesity
- Alzheimer's disease research and treatments
- Neurogenesis and neuroplasticity mechanisms
- MicroRNA in disease regulation
- Biochemical Analysis and Sensing Techniques
- Pain Mechanisms and Treatments
- Animal Genetics and Reproduction
- RNA regulation and disease
- Multiple Sclerosis Research Studies
- bioluminescence and chemiluminescence research
- Mitochondrial Function and Pathology
- Neuropeptides and Animal Physiology
- Botanical Research and Applications
- melanin and skin pigmentation
- Neurological disorders and treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Genetic Neurodegenerative Diseases
- Nerve injury and regeneration
- Neurological Disease Mechanisms and Treatments
- Tryptophan and brain disorders
Icahn School of Medicine at Mount Sinai
2025
University of Buenos Aires
2017-2024
Consejo Nacional de Investigaciones Científicas y Técnicas
2017-2024
Abstract Astrocytes are glial cells that help maintain brain homeostasis and become reactive in neurodegenerative processes releasing both harmful beneficial factors. We have demonstrated brain‐derived neurotrophic factor ( BDNF ) expression is induced by melanocortins astrocytes but actions largely unknown. hypothesize may prevent astrocyte death resulting neuroprotection. found increased viability, preventing apoptosis serum deprivation decreasing active caspase 3 p53 expression. The...
ABSTRACT Introduction The transgenic murine Cre/loxP system is deployed to investigate the role of central nervous (CNS) cell‐specific gene alterations in both healthy conditions and models neurologic disease. Aldh1l1‐Cre/ERT2 line widely used target astrocytes with high coverage specificity within CNS. Specificity outside CNS, however, has not been well‐characterized, Aldh1l1‐Cre/ERT2‐mediated recombination spleen reported. In many CNS diseases, infiltrating immune cells from periphery...
Abstract Background Evidence shows significant heterogeneity in astrocyte gene expression and function. We previously demonstrated that brain-derived neurotrophic factor (BDNF) exerts protective effects on whole brain primary cultured rat astrocytes treated with 3-nitropropionic acid (3NP), a mitochondrial toxin widely used as an vitro model of Huntington’s disease (HD). Therefore, we now investigated 3NP BDNF from two areas involved HD: the striatum entire cortex, their involvement neuron...
Recent findings relate obesity to inflammation in key hypothalamic areas for body weight control. Hypothalamic has also been related oxidative stress. Palmitic acid (PA) is the most abundant free fatty found food, and vitro studies indicate that it triggers a pro-inflammatory response brain. Melanocortins are neuropeptides with proven anti-inflammatory neuroprotective action mediated by melanocortin receptor 4 (MC4R), but little known about effect of melanocortins on The aim this study was...
Subtype 3 metabotropic glutamate receptor (mGlu3R) displays a broad range of neuroprotective effects. We previously demonstrated that mGlu3R activation in astrocytes protects hippocampal neurons from Aβ neurotoxicity through stimulation both neurotrophin release and uptake. Alternative-spliced variants were found human brains. The most prevalent variant, mGlu3Δ4, lacks exon 4 encoding the transmembrane domain can inhibit ligand binding to mGlu3R. To date, neither its role neurodegenerative...