A5058236253- Biochemical Analysis and Sensing Techniques
- Genetics, Aging, and Longevity in Model Organisms
- Circadian rhythm and melatonin
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Photoreceptor and optogenetics research
- Memory and Neural Mechanisms
- Psychological and Temporal Perspectives Research
- Neuroendocrine regulation and behavior
- RNA and protein synthesis mechanisms
- Neural and Behavioral Psychology Studies
- Computational Drug Discovery Methods
- Olfactory and Sensory Function Studies
- Bioactive Compounds and Antitumor Agents
- Infant Development and Preterm Care
Technion – Israel Institute of Technology
2018-2025
University of Haifa
2016
Institute of Neurobiology
2013
Dendrites are crucial for receiving information into neurons. Sensory experience affects the structure of these tree-like neurites, which, it is assumed, modifies neuronal function, yet evidence scarce, and mechanisms unknown. To study whether sensory dendritic morphology, we use Caenorhabditis elegans' arborized nociceptor PVD neurons, under natural mechanical stimulation induced by physical contacts between individuals. We found that mechanosensory signals conspecifics glass beads affect...
Learning of novel information, including taste, requires activation neuromodulatory transmission mediated, for example, by the muscarinic acetylcholine receptors (mAChRs) in relevant brain structures. In addition, drugs enhancing function mAChRs are used to treat memory impairment and decline. However, mechanisms underlying these effects poorly understood. Here, using quantitative RT-PCR Wistar Hola rats, we found quinone reductase 2 (QR2) be expressed cortex an mAChR-dependent manner. QR2...
Biochemical, electrophysiological, and imaging studies suggest that the anterior part of insular cortex (IC) serves as primary taste cortex, whereas fMRI in human propose IC is also involved processing general novelty or saliency information. Here, we compared activity regulated cytoskeleton associated protein (Arc)/Arg3.1 levels rat following administration familiar versus novel tastes. Surprisingly, there was no correlation between Arc/Arg3.1 when measured sum both left right cortices....
Abstract The current dogma suggests that the formation of long-term memory (LTM) is dependent on protein synthesis but persistence trace not. However, many studies examining effect inhibitors (PSIs) LTM were performed in hippocampus, which known to have a time-dependent role storage, rather than cortex, considered be main structure store memories. Here we studied PSIs and male Wistar Hola ( n ⩾5) rats by infusing inhibitor, anisomycin (100 μg, 1 μl), into gustatory cortex (GC) during...
Novel taste memories, critical for animal survival, are consolidated to form long term memories which dependent on translation regulation in the gustatory cortex (GC) hours following acquisition. However, role of transcription process is unknown. Here, we report that GC necessary learning rats, and drinking its consequences, as well novel experience, affect during memory consolidation. We show differential effects temporal dynamics set genes GC, including Arc/Arg3.1, known regulate...
Abstract Dendrites are crucial for receiving information into neurons. Sensory experience affects the structure of these tree-like neurites, which, it is assumed, modifies neuronal function, yet evidence scarce, and mechanisms unknown. To study whether sensory dendritic morphology, we use Caenorhabditis elegans ’ arborized nociceptor PVD neurons, under natural mechanical stimulation induced by physical contacts between individuals. We found that mechanosensory signals conspecifics affect...
Abstract Animals generate predictable patterns of behavior that are robustly synchronized with the developmental clock. However, long-term establishment time-locked behaviors across development, and neuronal alterations may impair them, remain underexplored. Here, by quantifying temporal synchronization in multiple isolated C. elegans individuals throughout their complete development time, we show robust behavioral consolidates stages as progresses. Analyses mutant populations perturbed...