A5077809727- Viral-associated cancers and disorders
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- interferon and immune responses
- Circular RNAs in diseases
- Herpesvirus Infections and Treatments
- Cancer-related molecular mechanisms research
- Cytomegalovirus and herpesvirus research
German Center for Infection Research
2020-2021
Helmholtz Zentrum München
2020-2021
Mammalian cells release different types of vesicles, collectively termed extracellular vesicles (EVs). EVs contain cellular microRNAs (miRNAs) with an apparent potential to deliver their miRNA cargo recipient affect the stability individual mRNAs and cells' transcriptome. The extent which miRNAs are exported via EV route whether they contribute cell-cell communication controversial. To address these issues, we defined multiple properties analyzed capacity packaged into target exert...
Epstein-Barr virus (EBV), a human herpesvirus, encodes 44 microRNAs (miRNAs), which regulate many genes with various functions in EBV-infected cells. Multiple target of the EBV miRNAs have been identified, some play important roles adaptive antiviral immune responses. Using mutant derivatives, we identified additional viral governing versatile type I interferon (IFN) responses upon infection primary mature B We also found that virus-encoded small RNAs (EBERs) and LF2, previously reported...
ABSTRACT Mammalian cells release different types of vesicles, collectively termed extracellular vesicles (EVs). EVs contain cellular microRNAs (miRNAs) with an apparent potential to deliver their miRNA cargo recipient affect the stability individual mRNAs and cells’ transcriptome. The extent which miRNAs are exported via EV route whether they contribute cell-cell communication controversial. To address these issues, we analyzed capacity packaged into target exert biological functions. We...
Abstract Epstein-Barr virus (EBV), a human herpes virus, encodes 44 microRNAs (miRNAs), which regulate many genes with various functions in EBV-infected cells. Multiple target of the EBV miRNAs have been identified, some play important roles adaptive antiviral immune responses. Using mutant derivatives, we identified additional viral governing versatile type I interferon (IFN) responses upon infection primary mature B We also found that virus-encoded small RNAs (EBERs) and LF2, previously...
Abstract Epstein-Barr virus (EBV), a member of the large herpesvirus family is very complex human γ -herpesvirus. Its complexity with respect to viral gene regulation, its preferred latent life style and technical difficulties are major obstacles, which hinder efficient generation in vitro mass-produce or establish recombinant wild-type EBV mutant derivatives. To explore conditions optimizing improving production, we established tested an library 77 expression plasmids set designed shRNAs....