Abstract Background The Chenopodium genus is a plant family widely spread worldwide that includes various species reputed to possess several medicinal virtues in folk medicines. ambrosioides L. among the most used plants traditional medicines worldwide. This review aimed highlight ethnomedicinal uses, phytochemical status, and pharmacological properties of C. Main body abstract analysis relevant data highlights uses against human veterinary diseases forty countries. Most indications...

Vernonia amygdalina possesses several bioactive compounds and is used in traditional medicines of southwestern Uganda, along with other regions. Its analgesic potential has not been investigated thus far. The present study examines the antinociceptive aqueous leaf extract (50–200 mg/kg) using three models nociception (acetic acid-induced writhing, formalin test, tail-flick test), antiplasmodial activity, toxicology extract. results show significantly inhibits acetic writhing test mice but...

In a double-blind randomized controlled trial, Esther Atukunda and colleagues evaluated whether sublingual misoprostol administered to women in labor was non-inferior intramuscular oxytocin preventing postpartum hemorrhage reducing blood loss. Please see later the article for Editors' Summary

Universal access to high quality essential medicines is critical sustainable development (SDG 3.8). However low- and middle-income countries struggle ensure all on their national lists (EML). Market registration the first step in determining both availability yet extent which are registered for use at country level not known. Companies apply a marketing authorisation, however low price or lack of market disincentive. Local production has been promoted but research this area also limited.The...

Comprehensive HIV treatment and care makes it safer for women living with (WLWH) to have the children they desire, partly through provision appropriate use of effective contraception. However, nearly one third WLWH in-care in a large Ugandan cohort became pregnant within 3 years initiating ART half these incident pregnancies (45%) were unplanned. We therefore describe future pregnancy plans associated factors among postpartum rural southwestern Uganda order inform interventions promoting...

Respiratory tract infections (RTI) are the second most frequent diagnosis after Malaria amongst Outpatients in Uganda. Majority Non pneumonia cough and flu which self-limiting often do not require antibacterials. However, antibiotics continuously prescribed for these conditions a major contributor to antimicrobial resistance wastage of health resources. Little is known about this problem Uganda hence impetus study.To determine antibacterial prescribing rate associated factors among RTI...

Physalis peruviana L. is among plant species possessing evident nutritional, nutraceutical, and commercial interests. This review highlights the complexity of chemical composition supporting multiple pharmacotherapeutic indications dietary values this through evidence-based studies from Google Scholar, PubMed/Medline, SciFinder, Science Direct, Scopus, Wiley online library, Web Science. The literature mentions at least 40 compounds isolated different parts; others are still under...

Diabetes mellitus is a metabolic disorder that poses major global health threat. The current diabetes uses insulin and oral hypoglycemic agents, which have limitations, including adverse effects secondary failures. Herbal medicine being evaluated for its role in the pharmacotherapy of diabetes. This study was aimed to assess anti-diabetic potential short-term toxicity level Chenopodium ambrosioides collected from Bukavu Democratic Republic Congo.Leaves C. were extracted by infusion...

Background Unwanted pregnancies remain a burden for women living with HIV (WLWH). Family planning prevents unplanned while promoting longer birth intervals, key strategies to eliminate perinatal transmission of and promote maternal child health. We evaluated the effect family voucher, inclusive immediate postpartum counseling, on uptake, early initiation, continuation modern contraceptive methods among recently WLWH delivering at publicly funded regional referral hospital in rural,...

Background: Physalis peruviana L. (Solanaceae) is a plant widely used in traditional medicine systems to manage various diseases, including diabetes mellitus, which remains global health problem developing and developed countries. This study aimed scientifically evaluate its antidiabetic bioactivity short-term toxicity rats. Methods: We prepared doses (100, 200, 400 mg/kg) of aqueous methanolic leaf extracts for the study, dose 2000 mg/Kg was acute test. The first group that evaluated...

Many low income countries struggle to provide safe and effective medicines due poor public health care infrastructure, budgetary constraints, lack of human resource capacity. Private sector pharmacies drug shops are used by a majority the population as an alternative pharmacies. This study looks at availability six essential in private outlets across Uganda.A standardised survey developed World Health Organization Action International was adapted for use this project collect data tracer 126...

Despite low pregnancy intentions, many women accessing contraception discontinue use, increasing the risk of unwanted pregnancies among living with HIV (WLWH). We evaluate whether a family planning support intervention, inclusive structured immediate one-on-one postpartum counseling, and follow-up mechanism through additional health information SMS reminders affects continuous contraceptive use incidence recently WLWH.We performed randomized controlled trial between October 2016 June 2018 at...

<em>Spathodea campanulata</em> (Bignoniaceae) P. Beauv. is a common medicinal plant in the central and south-western regions of Uganda. It popular for its use primarily treatment diabetes some other ailments. In this study antidiabetic properties an aqueous methanolic extract (SCE) stem bark were explored using experimental rat models. normoglycemic rats, reduced blood glucose levels with significant effect (p<0.05) after 2 h at 800 mg/kg dose. The standard chlorpropamide also produced...

Promoting antidiabetic phytomedicines necessitates evidence-based preclinical investigations, particularly in animal models. The present study investigated the validity of using streptozotocin-nicotinamide-induced type 2 diabetic (STZ/NA-induced T2DM) model to evaluate effects

Many low income countries struggle to provide safe and effective medicines due poor public health care infrastructure, budgetary constraints, lack of human resource capacity. Private sector pharmacies drug shops are used by a majority the population as an alternative pharmacies. This study looks at availability six essential in private outlets across Uganda. A standardised survey developed World Health Organization Action International was adapted for use this project collect data tracer 126...

BackgroundPoor access to essential medicines remains a barrier improvement of health in low-income countries. The maternal mortality rate from post-partum haemorrhage (PPH) Uganda is one the highest world. launched misoprostol rollout programme for prevention PPH 2009, before WHO added it Essential Medicines List. We assessed Uganda.MethodsWe reviewed relevant documents (WHO and Ministry Health guidelines, registration dossier), interviewed key informants, procurement data collected...

The use of herbal medicine products worldwide and in Uganda is on the rise there much-renewed interest their because belief that they are safe. However, this not backed up by credible scientific research for many Uganda. Almost all produced locally have no proof claimed safety efficacy treatment various conditions to treat example; covid-19, HIV, hypertension, erectile dysfunction, others. There an urgent need quickly improve enforced local order realise economic benefits which could be...

&lt;i&gt;Chenopodium ambrosioides&lt;/i&gt; is widely used in traditional medicines to manage several health conditions. This study aimed investigate the chemical composition of &lt;i&gt;n&lt;/i&gt;-hexane fraction and &lt;i&gt;in vitro&lt;/i&gt; antidiabetic antioxidant properties &lt;i&gt;C. L. The was determined using Gas Chromatography-Flame Ionization Detection Chromatography-Mass Spectrometry. &lt;i&gt;In evaluations were assessed by evaluating inhibitory potentials on activities...