A5100599515- Autophagy in Disease and Therapy
- Neuroendocrine Tumor Research Advances
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Lung Cancer Research Studies
- Global Healthcare and Medical Tourism
- Calcium signaling and nucleotide metabolism
- Infectious Diseases and Tuberculosis
- Neurosurgical Procedures and Complications
- Histone Deacetylase Inhibitors Research
- Cancer therapeutics and mechanisms
- Cell death mechanisms and regulation
- Intellectual Capital and Performance Analysis
- Diet, Metabolism, and Disease
- PARP inhibition in cancer therapy
- scientometrics and bibliometrics research
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Human Resource and Talent Management
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Transplantation: Methods and Outcomes
- Lysosomal Storage Disorders Research
- Alcohol Consumption and Health Effects
- Spinal Hematomas and Complications
- Patient Satisfaction in Healthcare
Sun Yat-sen University
2025
Zhejiang Provincial People's Hospital
2013-2023
Hangzhou Medical College
2018-2022
Weatherford College
2021
Qingdao University
2021
National Patient Safety Foundation
2021
Hangzhou Cancer Hospital
2020
Donghua University
2016
Artesunate (ART) is a prominent anti-malarial with significant anti-cancer properties. Our previous studies showed that ART enhances lysosomal function and ferritin degradation, which was necessary for its targeting to mitochondria also significantly improved efficacy, but the effect of on mitophagy, an important cellular pathway facilitates removal damaged mitochondria, remains unknown. Here, we first observed mainly localizes in probe labeling revealed it binds large number mitochondrial...
Parkin, an E3 ubiquitin ligase, plays a role in maintaining mitochondrial homeostasis through targeting damaged mitochondria for mitophagy. Accumulating evidence suggests that the acetylation modification of key mitophagy machinery influences level, but underlying mechanism is poorly understood. Here, our study demonstrated inhibition histone deacetylase (HDAC) by treatment HDACis activates mediating Parkin acetylation, leading to cervical cancer cell proliferation. Bioinformatics analysis...
Osteosarcoma is a primary malignant bone tumour with an unsatisfactory prognosis, and individualized comprehensive treatment needed. HP1 (α/β/γ) important heterochromatin protein involved in transcriptional regulation also the DNA damage response (DDR). However, little known about participation of damage-induced repression. In this study, proteins were shown to be damage-mediated repression at very onset damage. Mechanistically, recruited sites by interacting being covalently PARylated...
Abstract Docetaxel is an effective and commonly used chemotherapeutic drug for cancer. Autophagy has been reported to be involved in the anticancer mechanism of docetaxel. However, effect docetaxel on lysosomal function remains elusive. In present study, we first found that treatment enhances autophagic flux different cancer cells. Moreover, activates promotes its fusion with autophagosome. Second, doctaxel TFEB (transcription factor EB), a key nuclear transcription control lysosome...
The functional crosstalk between nonalcoholic fatty liver disease (NAFLD) and hypertension has been reported by some literatures; however, in nonhypertensive individuals, there is no article describes the characteristic of NAFLD. In this study, we aimed to determine strength association NAFLD with normal blood pressure (BP) individuals. This cross-sectional study was conducted sixth Affiliated Hospital Wenzhou Medical University, from October 2007 December 2011. brief, 24,200 subjects were...
Abstract Anlotinib is a receptor tyrosine kinase inhibitor with potential anti-neoplastic and anti-angiogenic activities. It has been approved for the treatment of non-small-cell lung cancer. Lysosomes are acidic organelles have implicated in various mechanisms cancer therapeutics. However, effect anlotinib on lysosomal function not investigated. In present study, induces apoptosis human colon cells. Through transcriptome sequencing, we found first time that upregulates ATP6V0E2 (ATPase H +...
Abstract Background To implement the “without need for a second visit” (WNASV) initiative in our hospital by optimizing outpatient clinic services via an upgraded information system, order to increase quality of medical and improve patients’ satisfaction. Methods An Internet-based care delivery approach was developed applied health services, simplify treatment process, reduce patient waiting time. The time consultation clinics during peak service intervals proportions various payment methods...
Objective To evaluate the concept of artery first and total mesopancreatic excision in radical resection pancreatic head carcinoma through both anterior posterior approaches.Method The approach was to identify superior mesenteric (SMA) confirm possibility negative margin at origin SMA,on posterio-lateral vascular wall vein (SMV) supposed mesopancreas.The scope were with celiac trunk common hepatic as upper boarder,the SMA left inferior (IMA) level lower boarder,to achieve a complete...
According to a lot of irregularities in the management scientific research funds China, this paper presents core is focus on design operation mechanism.It possible improve use efficiency and reduce unnecessary risks through establishment information communication mechanism, corresponding budget cost accounting mechanism supervision rational funds.
The paper probed into key challenges in talents introduction of hospitals, especially strategy and practical considerations.In its MVPPS (Money, Value, Platform, Promise, Service)theory framework, V(value)is the core, P(platform)is key, while P(promise)and M(money, remuneration)are cornerstone.The hospital can attract excellent by means common value, reasonable material conditions, ideal development platform service, promises fulfilled, thus achieving fast disciplines development. Key...
Abstract Background: Gallbladder neuroendocrine carcinomas (GB-NECs) are a group of rare and heterogeneous neoplasms. There few reports regarding laparoscopic surgery for GB-NEC cases diagnosed at advanced stage. Case presentation: Three patients, two females one male, were admitted to our hospital. Two patients had the chief complaint upper quadrant pain patient was found have gallbladder occupation during routine health checkup. No complained jaundice, weight loss, or carcinoid...